SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a8f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 5 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoB-5a8fA:
undetectable		 1dfoB-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 5 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoA-5a8fA:
undetectable		 1dfoA-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 5 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoD-5a8fA:
undetectable		 1dfoD-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 5 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.18A 1dfoC-5a8fA:
undetectable		 1dfoC-5a8fA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B;
Cardiovirus
B) 		4 / 4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.30A 1hrkB-5a8fA:
undetectable		 1hrkB-5a8fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN
(Cardiovirus
B) 		5 / 9 ASN B 110
LEU B  95
ALA B  99
LEU B  85
LEU B 220
 None
 1.48A 1hwiA-5a8fB:
undetectable		 1hwiA-5a8fB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U72_A_MTXA188_1
(DIHYDROFOLATE
REDUCTASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		5 / 12 ALA A 224
PHE A 206
ASN C 226
VAL A 200
TYR A 194
 None
 1.14A 1u72A-5a8fA:
undetectable		 1u72A-5a8fA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 6 VAL A 239
LEU A  46
PHE A 188
MET A 175
 None
 0.92A 1wrlB-5a8fA:
undetectable		 1wrlB-5a8fA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B;
Cardiovirus
B) 		4 / 4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.37A 2pnjB-5a8fA:
undetectable		 2pnjB-5a8fA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B;
Cardiovirus
B) 		4 / 4 LEU A  73
PRO A  74
LEU C 182
ARG A 252
 None
 1.45A 2qd2A-5a8fA:
undetectable		 2qd2A-5a8fA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN
(Cardiovirus
B) 		4 / 5 PRO B 168
ILE B 166
ARG B 172
ASP B 185
 None
 1.43A 2rhmB-5a8fB:
undetectable		 2rhmB-5a8fB:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 6 TYR A  37
TYR A 243
PHE A 122
PRO A 121
 None
 1.20A 2vmyA-5a8fA:
undetectable		 2vmyA-5a8fA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN
(Cardiovirus
B) 		5 / 10 PHE B 115
GLY B 123
PHE B 125
LEU B  78
THR B  73
 None
 1.39A 3a3yA-5a8fB:
undetectable		 3a3yA-5a8fB:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		4 / 5 PRO C 194
THR C  29
VAL C  30
GLY C  31
 None
 1.12A 3elzA-5a8fC:
undetectable		 3elzA-5a8fC:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		5 / 12 ALA C  87
VAL C  82
LEU C 198
ALA C 251
LEU C 208
 None
 1.16A 4qrcA-5a8fC:
undetectable		 4qrcA-5a8fC:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		4 / 5 ARG C 101
GLY C  90
ALA C  89
GLY C  93
 None
 0.94A 4u9uA-5a8fC:
undetectable		 4u9uA-5a8fC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		4 / 5 ARG C 101
GLY C  90
ALA C  89
GLY C  93
 None
 0.85A 4u9uB-5a8fC:
undetectable		 4u9uB-5a8fC:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN
(Cardiovirus
B) 		4 / 6 PHE B 161
THR B 162
TYR B 111
TYR B 105
 None
 1.26A 5lrbA-5a8fB:
undetectable		 5lrbA-5a8fB:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP1
(Cardiovirus
B) 		4 / 7 THR A 195
LEU A  69
VAL A 239
GLN A 112
 None
 1.04A 5tudA-5a8fA:
undetectable		 5tudA-5a8fA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		5 / 12 ALA C 232
PRO C 236
GLY C 124
ASP C 154
ARG C  81
 None
 1.35A 5zvgA-5a8fC:
undetectable		 5zvgA-5a8fC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5a8f HUMAN SAFFOLD
VIRUS-3 VP2
(Cardiovirus
B) 		5 / 12 ALA C 232
PRO C 236
GLY C 124
ASP C 154
ARG C  81
 None
 1.35A 5zvgB-5a8fC:
undetectable		 5zvgB-5a8fC:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 5a8f GENOME POLYPHUMAN
SAFFOLD VIRUS-3 VP3
PROTEIN
(Cardiovirus
B) 		4 / 8 VAL B  83
TYR B 129
ASN B 110
CYH B  48
 None
 1.27A 6gneB-5a8fB:
undetectable		 6gneB-5a8fB:
17.65