SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 10 PHE A 215
VAL A 221
VAL A  27
VAL A   6
ILE A 269
 None
 1.27A 1fe2A-5a8jA:
undetectable		 1fe2A-5a8jA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 9 ILE A 163
TYR A 186
ILE A 188
GLU A 200
LEU A 198
 None
 1.09A 3f78A-5a8jA:
17.3		 3f78A-5a8jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_A_MTXA603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 12 VAL A  27
ALA A 241
LEU A 254
LYS A 255
SER A 274
 None
 0.99A 4ky8A-5a8jA:
undetectable		 4ky8A-5a8jA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_B_MTXB603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 12 VAL A  27
ALA A 241
LEU A 254
LYS A 255
SER A 274
 None
 1.08A 4ky8B-5a8jA:
undetectable		 4ky8B-5a8jA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_C_MTXC603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 12 VAL A  27
ALA A 241
LEU A 254
LYS A 255
SER A 274
 None
 0.97A 4ky8C-5a8jA:
3.2		 4ky8C-5a8jA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_D_MTXD603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 12 VAL A  27
ALA A 241
LEU A 254
LYS A 255
SER A 274
 None
 1.00A 4ky8D-5a8jA:
undetectable		 4ky8D-5a8jA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KY8_E_MTXE603_1
(BIFUNCTIONAL
THYMIDYLATE
SYNTHASE-DIHYDROFOLA
TE REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 12 VAL A  27
ALA A 241
LEU A 254
LYS A 255
SER A 274
 None
 0.96A 4ky8E-5a8jA:
undetectable		 4ky8E-5a8jA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		4 / 5 LEU A   8
VAL A 293
VAL A 242
ARG A 286
 None
None
None
CIT  A1373 (-3.9A)
 1.06A 4r7iA-5a8jA:
undetectable		 4r7iA-5a8jA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		3 / 3 SER A 146
GLU A 225
GLU A 220
 SO4  A1367 (-3.4A)
GOL  A1369 (-3.0A)
None
 0.73A 4ymgB-5a8jA:
undetectable		 4ymgB-5a8jA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		4 / 6 ILE A  87
VAL A  43
VAL A 119
SER A  79
 None
 0.97A 5jwaH-5a8jA:
undetectable		 5jwaH-5a8jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		4 / 6 VAL A 206
VAL A 232
TYR A 209
ASN A  76
 None
None
GOL  A1368 (-3.0A)
None
 0.87A 5pbeA-5a8jA:
undetectable		 5pbeA-5a8jA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		5 / 11 ILE A 133
LEU A 134
LEU A 165
ILE A  58
MET A  52
 None
 1.02A 6fgcA-5a8jA:
4.0		 6fgcA-5a8jA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 147
LYS A 143
TYR A 149
 None
 1.36A 6gnaA-5a8jA:
1.8		 6gnaA-5a8jA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 5a8j VWA2
(Sulfolobus
acidocaldarius) 		3 / 3 ARG A 147
LYS A 143
TYR A 149
 None
 1.36A 6gnbA-5a8jA:
1.8		 6gnbA-5a8jA:
24.26