SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a8r'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_A_DVAA6_0 (GRAMICIDIN A)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ALA A 166 VAL A 213 TRP A 229	None	0.83A	1av2A-5a8rA: undetectable 1av2B-5a8rA: undetectable	1av2A-5a8rA: 4.08 1av2B-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AV2_D_DVAD6_0 (GRAMICIDIN A)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TRP A 229 ALA A 166 VAL A 213	None	0.79A	1av2C-5a8rA: undetectable 1av2D-5a8rA: undetectable	1av2C-5a8rA: 4.08 1av2D-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4S_A_TPVA201_1 (PROTEIN (HIV-1 PROTEASE))	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 10	LEU A 322 ASP A 318 ALA A 336 ILE A  97 GLY A 312	None	1.24A	1d4sA-5a8rA: undetectable	1d4sA-5a8rA: 12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.29A	1eqbA-5a8rC: undetectable 1eqbB-5a8rC: undetectable	1eqbA-5a8rC: 21.12 1eqbB-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_GLYA1292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 SER C 162 HIS C 161 ARG A 403	None	1.09A	1eqbA-5a8rC: undetectable 1eqbB-5a8rC: undetectable	1eqbA-5a8rC: 21.12 1eqbB-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.28A	1eqbA-5a8rC: undetectable 1eqbB-5a8rC: undetectable	1eqbA-5a8rC: 21.12 1eqbB-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_GLYB2292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 SER C 162 HIS C 161 ARG A 403	None	1.09A	1eqbA-5a8rC: undetectable 1eqbB-5a8rC: undetectable	1eqbA-5a8rC: 21.12 1eqbB-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.29A	1eqbC-5a8rC: undetectable 1eqbD-5a8rC: undetectable	1eqbC-5a8rC: 21.12 1eqbD-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_GLYC3292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 SER C 162 HIS C 161 ARG A 403	None	1.09A	1eqbC-5a8rC: undetectable 1eqbD-5a8rC: undetectable	1eqbC-5a8rC: 21.12 1eqbD-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.29A	1eqbC-5a8rC: undetectable 1eqbD-5a8rC: undetectable	1eqbC-5a8rC: 21.12 1eqbD-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_GLYD4292_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 SER C 162 HIS C 161 ARG A 403	None	1.09A	1eqbC-5a8rC: undetectable 1eqbD-5a8rC: undetectable	1eqbC-5a8rC: 21.12 1eqbD-5a8rC: 21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_CCSA381_0 (ESTROGEN RECEPTOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	GLU A 489 ALA A 411 SER A 432 HIS A 436	None	1.27A	1errA-5a8rA: undetectable 1errB-5a8rA: undetectable	1errA-5a8rA: 18.67 1errB-5a8rA: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ERR_A_CCSA381_0 (ESTROGEN RECEPTOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	HIS A 486 GLU A 489 ALA A 407 HIS A 397	DYA  A 452 ( 3.9A) None None MGN  A 402 ( 4.7A)	1.42A	1errA-5a8rA: undetectable 1errB-5a8rA: undetectable	1errA-5a8rA: 18.67 1errB-5a8rA: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IE9_A_VDXA500_1 (VITAMIN D3 RECEPTOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	LEU B 310 LEU B 311 SER B 216 SER B 215 VAL B 347	None	1.36A	1ie9A-5a8rB: undetectable	1ie9A-5a8rB: 19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IIU_A_RTLA176_0 (PLASMA RETINOL-BINDING PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 11	LEU A 536 ALA A 313 ALA A 311 MET A 100 LEU A  89	None	1.36A	1iiuA-5a8rA: undetectable	1iiuA-5a8rA: 15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LII_A_ADNA699_1 (ADENOSINE KINASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ILE B 415 GLY B 413 GLY B 416 LEU B 178 ASN B 107	None	0.96A	1liiA-5a8rB: undetectable	1liiA-5a8rB: 25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MCN_P_DHIP1_0 (IMMUNOGLOBULIN LAMBDA DIMER MCG (LIGHT CHAIN) PEPTIDE N-ACETYL-D-HIS-L-PRO -NH2)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	3 / 3	PHE C 146 TYR C 178 PRO C 148	None	1.16A	1mcnA-5a8rC: undetectable 1mcnB-5a8rC: undetectable 1mcnP-5a8rC: undetectable	1mcnA-5a8rC: 19.63 1mcnB-5a8rC: 19.63 1mcnP-5a8rC: 3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MEH_A_MOAA600_1 (INOSINE-5'-MONOPHOSP HATE DEHYDROGENASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 10	ASP A 103 ILE A 531 GLY A 534 GLU A 542 ARG A 219	None	1.25A	1mehA-5a8rA: undetectable	1mehA-5a8rA: 23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_G_AG2G7003_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.85A	1mt1G-5a8rA: undetectable 1mt1J-5a8rA: undetectable	1mt1G-5a8rA: 8.49 1mt1J-5a8rA: 12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MT1_K_AG2K7002_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 7	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.84A	1mt1H-5a8rA: undetectable 1mt1K-5a8rA: undetectable	1mt1H-5a8rA: 12.84 1mt1K-5a8rA: 8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_H_AG2H7012_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.82A	1n13H-5a8rA: undetectable 1n13K-5a8rA: undetectable	1n13H-5a8rA: 12.84 1n13K-5a8rA: 8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N13_J_AG2J7013_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE BETA CHAIN PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE ALPHA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 7	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.82A	1n13G-5a8rA: undetectable 1n13J-5a8rA: undetectable	1n13G-5a8rA: 8.49 1n13J-5a8rA: 12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SG9_A_SAMA301_1 (HEMK PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 4	THR B 403 GLY C  78 ASP C 132 ALA B 320	None	1.14A	1sg9A-5a8rB: undetectable	1sg9A-5a8rB: 22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1T6Z_A_RBFA296_1 (RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	VAL B  89 VAL B 138 GLU B  87 LEU B 105 ILE B 112	None	1.30A	1t6zA-5a8rB: undetectable	1t6zA-5a8rB: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TW4_A_CHDA130_1 (FATTY ACID-BINDING PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	3 / 3	TYR A 490 ARG C 244 GLN A 453	None None DYA  A 452 ( 4.6A)	0.91A	1tw4A-5a8rA: undetectable	1tw4A-5a8rA: 12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_B_HSMB402_1 (NITROPHORIN 1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	ASP C 252 THR C 245 LEU A 460 LEU C 246	None	1.21A	1u18B-5a8rC: undetectable	1u18B-5a8rC: 20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UAK_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	LEU B  57 ILE B 142 VAL B  79 LEU B  50 GLY B  52	None	0.92A	1uakA-5a8rB: undetectable	1uakA-5a8rB: 19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_A_DVAA6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ALA A 166 VAL A 213 TRP A 229	None	0.84A	1w5uA-5a8rA: undetectable 1w5uB-5a8rA: undetectable	1w5uA-5a8rA: 4.08 1w5uB-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TRP A 229 ALA A 166 VAL A 213	None	0.72A	1w5uA-5a8rA: undetectable 1w5uB-5a8rA: undetectable	1w5uA-5a8rA: 4.08 1w5uB-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1ZLQ_A_ACTA1502_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 5	TRP B 299 PRO B 296 GLY C 243 GLY B 346	None	1.18A	1zlqA-5a8rB: undetectable	1zlqA-5a8rB: 23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BFP_D_H4BD1290_1 (PTERIDINE REDUCTASE 1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	SER C 162 PHE A 398 LEU A  67 LEU A  72	None MGN  A 402 (-4.2A) None None	0.92A	2bfpD-5a8rC: undetectable	2bfpD-5a8rC: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BM9_D_SAMD301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	LEU B 218 LEU B  38 CYH B 398 ALA B 211 ALA B 395	None	1.17A	2bm9D-5a8rB: undetectable	2bm9D-5a8rB: 19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ILE B 422 LEU B 113 GLY B 416 SER B 412 ILE B 203	None	1.13A	2e7fA-5a8rB: undetectable	2e7fA-5a8rB: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E7F_B_C2FB4000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ILE B 422 LEU B 113 GLY B 416 SER B 412 ILE B 203	None	1.09A	2e7fB-5a8rB: undetectable	2e7fB-5a8rB: 22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_A_GBNA2414_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	GLY A 485 THR A 337 ALA A 338 ALA A 339	None None MGN  A 402 ( 3.7A) None	0.58A	2ej3A-5a8rA: undetectable	2ej3A-5a8rA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJ3_B_GBNB914_1 (BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 10	GLY A 485 GLU A 489 THR A 337 ALA A 338 ALA A 339	None None None MGN  A 402 ( 3.7A) None	1.03A	2ej3B-5a8rA: undetectable	2ej3B-5a8rA: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EJT_A_SAMA501_0 (N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 290 ILE A 511 ILE A 310 SER A 306 ALA A 314	None	1.17A	2ejtA-5a8rA: undetectable	2ejtA-5a8rA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FL5_F_RBFF204_1 (IMMUNOGLOBULIN IGG1 LAMBDA LIGHT CHAIN IMMUNOGLOBULIN IGG1 HEAVY CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	TYR C 108 ARG C 104 VAL C 115 TYR C 112	None	1.09A	2fl5E-5a8rC: undetectable 2fl5F-5a8rC: undetectable	2fl5E-5a8rC: 19.70 2fl5F-5a8rC: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HKK_A_ALEA300_1 (CARBONIC ANHYDRASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ASN A 479 HIS B 384 ASN A 458 ILE A 462	SMC  A 454 ( 3.6A) SMC  A 454 ( 4.3A) SMC  A 454 ( 3.9A) None	1.11A	2hkkA-5a8rA: undetectable	2hkkA-5a8rA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_A_DVAA6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ALA A 166 VAL A 213 TRP A 229	None	0.70A	2izqA-5a8rA: undetectable 2izqB-5a8rA: undetectable	2izqA-5a8rA: 4.08 2izqB-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_D_DVAD6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TRP A 229 ALA A 166 VAL A 213	None	0.87A	2izqC-5a8rA: undetectable 2izqD-5a8rA: undetectable	2izqC-5a8rA: 4.08 2izqD-5a8rA: 4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LBD_A_REAA500_1 (RETINOIC ACID RECEPTOR GAMMA)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ARG C 177 ILE C 153 PHE C  90 GLY C 205 LEU C 208	None	1.31A	2lbdA-5a8rC: undetectable	2lbdA-5a8rC: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA501_1 (CYTOCHROME P450 2C8)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 11	GLY A  79 SER A 526 ILE A 531 ALA A 315 ILE A 310	None	1.02A	2nnhA-5a8rA: undetectable	2nnhA-5a8rA: 22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_1 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 4	PRO C 201 ASP C  38 ASP C  36 ASP C 203	None	1.34A	2nyuA-5a8rC: undetectable	2nyuA-5a8rC: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ILE B 422 LEU B 113 GLY B 416 SER B 412 ILE B 203	None	1.14A	2ogyA-5a8rB: undetectable	2ogyA-5a8rB: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_B_C2FB4000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ILE B 422 LEU B 113 GLY B 416 SER B 412 ILE B 203	None	1.11A	2ogyB-5a8rB: undetectable	2ogyB-5a8rB: 20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OTH_A_IMNA301_1 (PHOSPHOLIPASE A2 VRV-PL-VIIIA)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	3 / 3	ASP B   6 TYR B   4 LYS C 260	None	0.82A	2othA-5a8rB: undetectable	2othA-5a8rB: 12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PRG_B_BRLB2_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	SER B 329 HIS B 364 VAL C 136 LEU C 120 TYR A 446	None None None COM  A 601 ( 4.6A) None	1.44A	2prgB-5a8rB: undetectable	2prgB-5a8rB: 21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QL8_B_BEZB143_0 (PUTATIVE REDOX PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 6	TYR B 340 ALA A 439 ARG C  18 PRO C   9	None	1.21A	2ql8A-5a8rB: undetectable 2ql8B-5a8rB: undetectable	2ql8A-5a8rB: 17.46 2ql8B-5a8rB: 17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQC_E_AG2E671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 7	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.82A	2qqcD-5a8rA: undetectable 2qqcE-5a8rA: undetectable	2qqcD-5a8rA: 12.66 2qqcE-5a8rA: 8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QQD_B_AG2B671_1 (PYRUVOYL-DEPENDENT ARGININE DECARBOXYLASE (EC 4.1.1.19) (PVLARGDC))	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	LEU A 536 ASP A  88 LEU A  89 GLY A  86	None	0.87A	2qqdB-5a8rA: undetectable 2qqdC-5a8rA: undetectable	2qqdB-5a8rA: 12.84 2qqdC-5a8rA: 15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2R2V_C_ACTC36_0 (GCN4 LEUCINE ZIPPER)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 10	SER A 383 ALA A 410 ALA A 408 ALA A 411 SER A 376	None	1.21A	2r2vC-5a8rA: undetectable 2r2vF-5a8rA: undetectable 2r2vG-5a8rA: undetectable	2r2vC-5a8rA: 5.50 2r2vF-5a8rA: 5.50 2r2vG-5a8rA: 5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_A_GLYA502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.30A	2vmyA-5a8rC: undetectable 2vmyB-5a8rC: undetectable	2vmyA-5a8rC: 23.00 2vmyB-5a8rC: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 HIS C 159 HIS C 161 ARG A 403	None	1.34A	2vmyA-5a8rC: undetectable 2vmyB-5a8rC: undetectable	2vmyA-5a8rC: 23.00 2vmyB-5a8rC: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VMY_B_GLYB502_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 8	SER C 121 SER C 162 HIS C 161 ARG A 403	None	1.17A	2vmyA-5a8rC: undetectable 2vmyB-5a8rC: undetectable	2vmyA-5a8rC: 23.00 2vmyB-5a8rC: 23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_A_P1ZA1351_1 (PROSTAGLANDIN REDUCTASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 10	ILE A 239 TYR A 135 LEU A 119 VAL A 118 LEU A 123	None	1.24A	2w98A-5a8rA: undetectable	2w98A-5a8rA: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 8	ILE A 239 TYR A 135 LEU A 119 VAL A 118 LEU A 123	None	1.23A	2w98B-5a8rA: undetectable	2w98B-5a8rA: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	ILE C 126 PHE C  90 LEU C  43 VAL C  42	None	0.89A	2w98B-5a8rC: undetectable	2w98B-5a8rC: 21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WA2_A_SAMA1248_0 (NON-STRUCTURAL PROTEIN 5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLY A 455 GLY A 412 GLY A 428 SER A 459 THR A 415	SMC  A 454 ( 2.4A) None None None None	1.19A	2wa2A-5a8rA: undetectable	2wa2A-5a8rA: 18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2I_D_QPSD1060_1 (ALPHA-1,4-GLUCAN LYASE ISOZYME 1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	THR B 403 SER B 329 ASN B 317 VAL B 318 GLN B 404	None	1.48A	2x2iD-5a8rB: undetectable	2x2iD-5a8rB: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_A_X2NA1480_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	MET B 161 PHE B 170 TYR B 164 ALA B 153 ALA B 131	None	1.17A	2x2nA-5a8rB: undetectable	2x2nA-5a8rB: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2X2N_B_X2NB1479_1 (LANOSTEROL 14-ALPHA-DEMETHYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	MET B 161 PHE B 170 TYR B 164 ALA B 153 ALA B 131	None	1.10A	2x2nB-5a8rB: 0.9	2x2nB-5a8rB: 21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRZ_A_ACTA1470_0 (DEOXYRIBODIPYRIMIDIN E PHOTOLYASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	ARG A 297 ALA A 516 ASP A 517 GLU A 190	None	1.15A	2xrzA-5a8rA: 2.5	2xrzA-5a8rA: 21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZJ0_A_2FAA500_2 (ADENOSYLHOMOCYSTEINA SE)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	THR C 119 THR C 218 HIS C  21 LEU C 145	None	1.30A	2zj0A-5a8rC: undetectable	2zj0A-5a8rC: 22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZQ9_A_CLSA11_1 (BETA-LACTAMASE TOHO-1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 4	GLU A  41 ARG A  38 ASN A  93 ASP A  88	None	1.08A	2zq9A-5a8rA: 1.3	2zq9A-5a8rA: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZW9_A_SAMA801_1 (LEUCINE CARBOXYL METHYLTRANSFERASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	THR C 143 ARG C 104 ASP C  36 SER C 137	None	0.94A	2zw9A-5a8rC: undetectable	2zw9A-5a8rC: 16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A2Q_A_ACAA602_1 (6-AMINOHEXANOATE-CYC LIC-DIMER HYDROLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 7	SER A 376 ALA A 408 ALA A 407 ALA A 411	None	0.65A	3a2qA-5a8rA: undetectable	3a2qA-5a8rA: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A50_B_VD3B2001_1 (VITAMIN D HYDROXYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	ILE B 217 ASN B 250 LEU B 241 ILE B  27 PRO B 428	None	1.38A	3a50B-5a8rB: 1.3	3a50B-5a8rB: 24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AXT_A_SAMA397_0 (PROBABLE N(2),N(2)-DIMETHYLGU ANOSINE TRNA METHYLTRANSFERASE TRM1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 290 ILE A 511 ILE A 310 SER A 306 ALA A 314	None	1.22A	3axtA-5a8rA: undetectable	3axtA-5a8rA: 20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_E_SVRE510_3 (PHOSPHOLIPASE A2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	VAL B 201 VAL B 200 THR B 411 THR B 208	None	1.09A	3bjwG-5a8rB: undetectable	3bjwG-5a8rB: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_1 (PHOSPHOLIPASE A2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	VAL B 201 VAL B 200 THR B 411 THR B 208	None	1.11A	3bjwC-5a8rB: undetectable	3bjwC-5a8rB: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_H_SVRH511_2 (PHOSPHOLIPASE A2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	VAL B 201 VAL B 200 THR B 411 THR B 208	None	1.19A	3bjwD-5a8rB: 0.9	3bjwD-5a8rB: 11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BPX_A_SALA257_1 (TRANSCRIPTIONAL REGULATOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 8	SER B 215 ALA B 389 THR B 382 THR B 355	None	0.91A	3bpxA-5a8rB: undetectable 3bpxB-5a8rB: undetectable	3bpxA-5a8rB: 15.12 3bpxB-5a8rB: 15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_A_ADNA500_2 (ADENOSYLHOMOCYSTEINA SE)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	THR C 119 THR C 218 HIS C  21 LEU C 145	None	1.32A	3ce6A-5a8rC: undetectable	3ce6A-5a8rC: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CE6_C_ADNC500_2 (ADENOSYLHOMOCYSTEINA SE)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	THR C 119 THR C 218 HIS C  21 LEU C 145	None	1.32A	3ce6C-5a8rC: undetectable	3ce6C-5a8rC: 21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_A_REMA350_2 (RENIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	TYR A 480 ALA A 313 TYR A 325 MET A 270	None None None AGM  A 274 ( 4.0A)	1.24A	3d91A-5a8rA: undetectable	3d91A-5a8rA: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3DAT_A_MTXA201_1 (DIHYDROFOLATE REDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ALA C 105 GLN B 325 VAL C 115 ILE C  88 LEU C 133	None	0.99A	3datA-5a8rC: undetectable	3datA-5a8rC: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	ASN A 140 HIS A 141 VAL A 148	None None F43  A 603 (-3.5A)	0.84A	3elzB-5a8rA: undetectable	3elzB-5a8rA: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJ3_A_MTXA605_1 (CHAIN A, CRYSTAL STRUCTURE OF DHFR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	LEU B 218 THR B  34 ILE B  35 LEU B 241 THR B 204	None	1.10A	3hj3A-5a8rB: undetectable	3hj3A-5a8rB: 21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZJ_A_ACRA405_1 (ACARBOSE/MALTOSE BINDING PROTEIN GACH)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	GLY B 240 GLU B 219 ALA B 222 ASP B 348 GLY B 377	None	1.19A	3jzjA-5a8rB: undetectable	3jzjA-5a8rB: 23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_B_30BB500_1 (GENOME POLYPROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	HIS B 364 ASP C 116 VAL B 381 GLY B 370 ALA B 328	None	1.08A	3keeB-5a8rB: undetectable	3keeB-5a8rB: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KEE_C_30BC500_1 (GENOME POLYPROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	HIS B 364 ASP C 116 VAL B 381 GLY B 370 ALA B 328	None	1.09A	3keeC-5a8rB: undetectable	3keeC-5a8rB: 19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_G_SAMG226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	PRO B 428 GLY B 416 ALA B 197 LEU B 178 ILE B 415	None	1.06A	3ku1G-5a8rB: undetectable	3ku1G-5a8rB: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KU1_H_SAMH226_0 (SAM-DEPENDENT METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	PRO B 428 GLY B 416 ALA B 197 LEU B 178 ILE B 415	None	1.04A	3ku1H-5a8rB: undetectable	3ku1H-5a8rB: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KVV_D_URFD254_1 (URIDINE PHOSPHORYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLY A 145 GLN A 233 MET A 236 VAL A 156	None F43  A 603 (-3.5A) F43  A 603 (-3.8A) None	1.14A	3kvvD-5a8rA: undetectable	3kvvD-5a8rA: 17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_B_DVAB6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TRP A 229 ALA A 166 VAL A 213	None	0.86A	3l8lA-5a8rA: undetectable 3l8lB-5a8rA: undetectable	3l8lA-5a8rA: 4.08 3l8lB-5a8rA: 4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3L8L_D_DVAD6_0 (GRAMICIDIN D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TRP A 229 ALA A 166 VAL A 213	None	0.79A	3l8lC-5a8rA: undetectable 3l8lD-5a8rA: undetectable	3l8lC-5a8rA: 4.08 3l8lD-5a8rA: 4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LB3_A_4CHA191_0 (DEHALOPEROXIDASE A)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	PHE B 359 HIS B 376 THR B 382 VAL B 381	None	1.22A	3lb3A-5a8rB: undetectable	3lb3A-5a8rB: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LB3_B_4CHB192_0 (DEHALOPEROXIDASE A)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	PHE B 359 HIS B 376 THR B 382 VAL B 381	None	1.22A	3lb3B-5a8rB: undetectable	3lb3B-5a8rB: 15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 7	GLN C 193 LEU C 145 ILE C 153 PHE C  90	None	1.04A	3ln1C-5a8rC: undetectable	3ln1C-5a8rC: 17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MG0_K_BO2K1402_1 (PROTEASOME COMPONENT PRE2 PROTEASOME COMPONENT C5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 11	ALA A 418 THR A 419 VAL A 356 ALA A 411 GLY A 412	None	0.96A	3mg0K-5a8rA: undetectable 3mg0L-5a8rA: undetectable	3mg0K-5a8rA: 18.05 3mg0L-5a8rA: 17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3NU4_B_478B401_2 (PROTEASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 9	LEU B  18 GLY B 435 ALA B 436 ILE B   8 ILE B 217	None	0.80A	3nu4B-5a8rB: undetectable	3nu4B-5a8rB: 13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P5N_B_RBFB190_1 (RIBOFLAVIN UPTAKE PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	THR C 117 ASN B 317 GLY B 326 ALA B 328 ALA B 356	None	1.14A	3p5nB-5a8rC: undetectable	3p5nB-5a8rC: 17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3QX3_A_EVPA1_1 (DNA TOPOISOMERASE 2-BETA)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	GLY A 223 ASP A 222 ARG A 276 GLN A  98	None	1.29A	3qx3A-5a8rA: undetectable	3qx3A-5a8rA: 21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3N_A_DLUA398_1 (PFV INTEGRASE)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	ASP C 203 GLY C 205 TYR C 189 PRO C 201	None	0.94A	3s3nA-5a8rC: undetectable	3s3nA-5a8rC: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUF_B_SUEB1201_2 (NS3 PROTEASE, NS4A PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	TYR A 202 LEU A 175 ARG A 206	None	0.80A	3sufB-5a8rA: undetectable	3sufB-5a8rA: 17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3T3S_E_9PLE1_1 (CYTOCHROME P450 2A13)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	PHE C 146 ALA C  97 PHE C  90 ALA C  91	None	0.97A	3t3sE-5a8rC: undetectable	3t3sE-5a8rC: 19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEG_A_DAHA416_1 (PHENYLALANYL-TRNA SYNTHETASE, MITOCHONDRIAL)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	GLN A 433 PHE A 445 GLY A 400 ALA A 404 GLY A 485	DYA  A 452 ( 3.9A) GL3  A 447 (-3.9A) MGN  A 402 ( 4.2A) None None	1.17A	3tegA-5a8rA: 3.9	3tegA-5a8rA: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TEH_B_DAHB786_1 (PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 7	HIS C 159 LEU C 163 GLY C 122 ALA C  91	None	1.00A	3tehB-5a8rC: undetectable	3tehB-5a8rC: 17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UQ6_A_ADNA401_2 (ADENOSINE KINASE, PUTATIVE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	LEU B 332 ALA B 328 MET C 109 ASN B 317	None	1.42A	3uq6A-5a8rB: undetectable	3uq6A-5a8rB: 22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UR0_B_SVRB516_1 (RNA-DEPENDENT RNA POLYMERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 7	ALA B 321 ALA B 401 ASP B 400 ARG B 322	None	0.77A	3ur0B-5a8rB: undetectable	3ur0B-5a8rB: 23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH504_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	LYS B 282 GLU B 295 TRP B 299	None	0.94A	3v4tH-5a8rB: undetectable	3v4tH-5a8rB: 24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_A_W9TA1002_1 (HEMOLYTIC LECTIN CEL-III)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	3 / 3	ASP C 147 GLU C 212 GLY C 209	None	0.62A	3w9tA-5a8rC: undetectable	3w9tA-5a8rC: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AZV_A_SAMA1474_1 (WBDD)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 6	TYR A 446 ARG C 123 ASP A 449 GLU A 438	None COM  A 601 (-3.9A) None None	1.34A	4azvA-5a8rA: undetectable	4azvA-5a8rA: 22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4E1V_F_URFF1301_1 (URIDINE PHOSPHORYLASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLY A 145 GLN A 233 MET A 236 VAL A 156	None F43  A 603 (-3.5A) F43  A 603 (-3.8A) None	1.11A	4e1vF-5a8rA: undetectable	4e1vF-5a8rA: 19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EB6_C_VLBC503_1 (TUBULIN BETA CHAIN TUBULIN ALPHA CHAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	VAL B 293 THR C   8 PRO C   9 VAL B 272 ILE B 268	None	1.40A	4eb6B-5a8rB: undetectable 4eb6C-5a8rB: undetectable	4eb6B-5a8rB: 21.10 4eb6C-5a8rB: 21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EOH_A_TEPA402_1 (PYRIDOXAL KINASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	SER B 216 GLY B 387 THR B 308 VAL B 347	None	0.87A	4eohA-5a8rB: undetectable	4eohA-5a8rB: 21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGZ_B_CQAB302_0 (PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 8	SER A 401 TYR A 477 ARG A 473 GLY A 455	MGN  A 402 ( 4.4A) None None SMC  A 454 ( 2.4A)	1.06A	4fgzA-5a8rA: undetectable 4fgzB-5a8rA: undetectable	4fgzA-5a8rA: 17.81 4fgzB-5a8rA: 17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_C_SAMC401_1 (METHYLTRANSFERASE NSUN4)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	ASP B 278 ARG B 274 ASP B 298	None	0.86A	4fp9C-5a8rB: undetectable	4fp9C-5a8rB: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FP9_F_SAMF401_1 (METHYLTRANSFERASE NSUN4)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	ASP B 278 ARG B 274 ASP B 298	None	0.86A	4fp9F-5a8rB: undetectable	4fp9F-5a8rB: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FWD_A_BO2A801_1 (TTC1975 PEPTIDASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 9	VAL B  42 VAL B  39 VAL B 200 ILE B 195 GLY B 191	None	1.25A	4fwdA-5a8rB: undetectable	4fwdA-5a8rB: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G1B_B_ECNB403_1 (FLAVOHEMOGLOBIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	ILE B  85 GLN B 110 ALA B  51 LEU B  50 VAL B  48	None	1.12A	4g1bB-5a8rB: undetectable	4g1bB-5a8rB: 19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JTR_A_IBPA401_1 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 8	TYR B 243 TRP B 302 LEU B 255 LEU B 271	None	1.01A	4jtrA-5a8rB: undetectable	4jtrA-5a8rB: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K7A_A_MXDA1002_1 (ANDROGEN RECEPTOR)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	3 / 3	GLU B 341 TRP C 110 LYS B 292	None	0.95A	4k7aA-5a8rB: undetectable	4k7aA-5a8rB: 19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_A_MTLA804_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 6	GLU B   5 ARG B 235 ASP C 256 ASP C 257	None	1.40A	4kcnA-5a8rB: undetectable	4kcnA-5a8rB: 21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KMU_H_RFPH1401_1 (DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 12	ASP C 192 SER C 137 LEU C 140 ARG C 104 ILE C  88	None	1.45A	4kmuH-5a8rC: undetectable	4kmuH-5a8rC: 12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LVC_A_ADNA501_2 (S-ADENOSYL-L-HOMOCYS TEINE HYDROLASE (SAHASE))	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	THR C 119 THR C 218 HIS C  21 LEU C 145	None	1.39A	4lvcA-5a8rC: undetectable	4lvcA-5a8rC: 21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLT_A_GCSA302_1 (CHITOSANASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ARG B 163 THR B 171 THR B 167 ASP B 169	None	1.31A	4oltA-5a8rB: undetectable	4oltA-5a8rB: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OLT_B_GCSB302_1 (CHITOSANASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ARG B 163 THR B 171 THR B 167 ASP B 169	None	1.31A	4oltB-5a8rB: undetectable	4oltB-5a8rB: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PCL_B_SAMB301_0 (O-METHYLTRANSFERASE FAMILY PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	GLN B 110 GLU B  54 GLY B  55 ASN B  49 ALA B  61	None	1.34A	4pclB-5a8rB: undetectable	4pclB-5a8rB: 19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QN9_B_DXCB610_0 (N-ACYL-PHOSPHATIDYLE THANOLAMINE-HYDROLYZ ING PHOSPHOLIPASE D)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	3 / 3	GLY B 371 PRO B 372 ALA B 328	None	0.48A	4qn9B-5a8rB: undetectable	4qn9B-5a8rB: 24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWP_A_GCSA302_1 (CHITOSANASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ARG B 163 THR B 171 THR B 167 ASP B 169	None	1.29A	4qwpA-5a8rB: undetectable	4qwpA-5a8rB: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QWP_B_GCSB306_1 (CHITOSANASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ARG B 163 THR B 171 THR B 167 ASP B 169	None	1.24A	4qwpB-5a8rB: 0.0	4qwpB-5a8rB: 19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R1Z_A_AERA601_1 (CYP17A1 PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 9	ALA C  99 ILE C  88 ASP C  92 GLY C 152 VAL C 141	None	1.17A	4r1zA-5a8rC: undetectable	4r1zA-5a8rC: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_A_P06A801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 4	GLY A 224 LEU A 316 PHE A 289 ILE A 104	None	0.99A	4xv2A-5a8rA: undetectable	4xv2A-5a8rA: 19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YMG_A_SAMA1001_0 (PUTATIVE SAM-DEPENDENT O-METHYLTRANFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	5 / 12	GLY B 354 TYR A 448 SER B 329 ALA B 389 ASN B 335	SMC  A 454 ( 3.8A) DYA  A 452 ( 4.5A) None None None	1.28A	4ymgA-5a8rB: undetectable	4ymgA-5a8rB: 20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_A_SORA1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.27A	5a06A-5a8rB: undetectable	5a06A-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_B_SORB1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.28A	5a06B-5a8rB: undetectable	5a06B-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_C_SORC1341_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.25A	5a06C-5a8rB: undetectable	5a06C-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_D_SORD1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.25A	5a06D-5a8rB: undetectable	5a06D-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_E_SORE1342_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.28A	5a06E-5a8rB: undetectable	5a06E-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5A06_F_SORF1343_0 (ALDOSE-ALDOSE OXIDOREDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 7	ARG B 383 ARG A 463 ASP B 228 TYR B 190	None	1.28A	5a06F-5a8rB: undetectable	5a06F-5a8rB: 23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5AYF_A_C7HA402_1 (HISTONE-LYSINE N-METHYLTRANSFERASE SETD7)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	TYR B 367 GLY A 331 TYR A 335 GLY A 485	None None COM  A 601 ( 4.9A) None	1.02A	5ayfA-5a8rB: undetectable	5ayfA-5a8rB: 19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EUM_B_ACTB603_0 (LIPID A EXPORT ATP-BINDING/PERMEASE PROTEIN MSBA)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 4	ALA B 320 ASN B 317 ARG C 113 ILE C  76	None	1.48A	5eumB-5a8rB: undetectable	5eumB-5a8rB: 21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_A_SAMA301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 115 LEU A 119 ALA A 231 GLY A 235 SER A 237	None	1.15A	5jglA-5a8rA: undetectable	5jglA-5a8rA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_B_SAMB301_0 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 115 LEU A 119 ALA A 231 GLY A 235 SER A 237	None	1.14A	5jglB-5a8rA: undetectable	5jglB-5a8rA: 18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JW1_B_CELB602_1 (PROSTAGLANDIN G/H SYNTHASE 2)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ALA A 246 VAL A 148 GLY A 146 ALA A 142 LEU A 143	F43  A 603 (-3.3A) F43  A 603 (-3.5A) None None None	1.10A	5jw1B-5a8rA: undetectable	5jw1B-5a8rA: 20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L8D_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	THR A  43 PRO A  61 ASP A  62	None	0.94A	5l8dB-5a8rA: undetectable	5l8dB-5a8rA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_C_PFLC407_1 (PROTON-GATED ION CHANNEL)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 9	TYR B 333 TYR C 102 TYR C 108 THR C 117 ILE C 126	None	1.43A	5mvnC-5a8rB: 1.1	5mvnC-5a8rB: 11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVN_D_PFLD410_1 (PROTON-GATED ION CHANNEL)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	5 / 10	TYR B 333 TYR C 102 TYR C 108 THR C 117 ILE C 126	None	1.42A	5mvnD-5a8rB: undetectable	5mvnD-5a8rB: 11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVS_B_ADNB401_1 (HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 8	ALA B 304 ASP B 348 PHE B 349 PHE C 254	None	0.97A	5mvsB-5a8rB: undetectable	5mvsB-5a8rB: 22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MWU_B_ACTB601_0 (NICKEL-BINDING PERIPLASMIC PROTEIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	3 / 3	THR A  43 PRO A  61 ASP A  62	None	0.94A	5mwuB-5a8rA: undetectable	5mwuB-5a8rA: 20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OM3_B_DXTB501_1 (ALPHA-1-ANTICHYMOTRY PSIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	LEU A   8 PHE A   7 ASP A 343 HIS A 397	None None None MGN  A 402 ( 4.7A)	1.02A	5om3A-5a8rA: undetectable 5om3B-5a8rA: undetectable	5om3A-5a8rA: 10.26 5om3B-5a8rA: 6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UIG_A_EDTA501_0 (ADENOSINE RECEPTOR A2A,SOLUBLE CYTOCHROME B562,ADENOSINE RECEPTOR A2A)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 6	ASN B 207 THR B 208 ILE B 429 GLU B 427	None	1.29A	5uigA-5a8rB: undetectable	5uigA-5a8rB: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5W4Z_A_RBFA502_2 (RIBOFLAVIN LYASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 5	ASN B  37 ASP B  41 SER B  40 ARG B  44	None	1.47A	5w4zA-5a8rB: undetectable	5w4zA-5a8rB: 12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_A_SAMA901_0 (MRNA CAPPING ENZYME P5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	VAL B 347 GLY B 346 GLU B 339 ALA B 352 LEU B 310	None	1.14A	5x6yA-5a8rB: undetectable	5x6yA-5a8rB: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_B_SAMB901_0 (MRNA CAPPING ENZYME P5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	VAL B 347 GLY B 346 GLU B 339 ALA B 352 LEU B 310	None	1.22A	5x6yB-5a8rB: undetectable	5x6yB-5a8rB: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X6Y_C_SAMC901_0 (MRNA CAPPING ENZYME P5)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 11	VAL B 347 GLY B 346 GLU B 339 ALA B 352 LEU B 310	None	1.18A	5x6yC-5a8rB: undetectable	5x6yC-5a8rB: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YSI_A_NCAA1001_0 (UBIQUITINATING/DEUBI QUITINATING ENZYME SDEA)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 6	GLY A 428 SER A 414 THR A 419 VAL A 372	None	1.20A	5ysiA-5a8rA: undetectable	5ysiA-5a8rA: 14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_A_SUEA1202_0 (NS3 PROTEASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ILE A 310 GLY A 412 SER A 414 PHE A 417 ALA A 303	None	1.13A	6c2mA-5a8rA: undetectable	6c2mA-5a8rA: 8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6C2M_B_SUEB1202_0 (NS3 PROTEASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	ILE A 310 GLY A 412 SER A 414 PHE A 417 ALA A 303	None	1.11A	6c2mB-5a8rA: undetectable	6c2mB-5a8rA: 8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CLX_A_SAMA401_0 (O-METHYLTRANSFERASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 12	ALA B 328 GLY B 373 GLY B 371 VAL B 393 ASP B 400	None	1.23A	6clxA-5a8rB: undetectable	6clxA-5a8rB: 22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DEB_B_MTXB303_1 (BIFUNCTIONAL PROTEIN FOLD)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	4 / 5	TYR A 317 GLN A 487 GLY A 223 ILE A 104	None	1.43A	6debB-5a8rA: undetectable	6debB-5a8rA: 8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6DJZ_C_GMJC301_1 (SIGMA NON-OPIOID INTRACELLULAR RECEPTOR 1)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis; Methanothermobac ter marburgensis)	4 / 6	LEU A 468 TYR B 190 ASP B 228 GLN B 220	None	1.41A	6djzC-5a8rA: undetectable	6djzC-5a8rA: 17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GBN_D_ADND501_2 (-)	5a8r	METHYL-COENZYME M REDUCTASE II, SUBUNIT BETA (Methanothermobac ter marburgensis)	4 / 5	THR C 119 THR C 218 HIS C  21 LEU C 145	None	1.40A	6gbnD-5a8rC: undetectable	6gbnD-5a8rC: 20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GSD_A_STRA401_0 (PROGESTERONE 5-BETA-REDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	PHE A 515 ILE A 511 ASN A 279 VAL A 108 ILE A 109	None	1.34A	6gsdA-5a8rA: undetectable	6gsdA-5a8rA: 8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GSD_A_STRA401_0 (PROGESTERONE 5-BETA-REDUCTASE)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT ALPHA (Methanothermobac ter marburgensis)	5 / 12	PHE A 515 ILE A 511 ASN A 279 VAL A 108 ILE A 264	None	1.21A	6gsdA-5a8rA: undetectable	6gsdA-5a8rA: 8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HQB_A_PQNA2001_0 (PHOTOSYSTEM I P700 CHLOROPHYLL A APOPROTEIN A1 PHOTOSYSTEM I REACTION CENTER SUBUNIT IX)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	5 / 10	GLY B 326 ALA B 396 LEU B 399 GLY B 319 LEU B  18	None	1.34A	6hqbA-5a8rB: undetectable 6hqbJ-5a8rB: undetectable	6hqbA-5a8rB: 11.29 6hqbJ-5a8rB: 7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6MDQ_A_TESA605_0 (SERUM ALBUMIN)	5a8r	METHYL-COENZYME M REDUCTASE II SUBUNIT GAMMA (Methanothermobac ter marburgensis)	4 / 8	GLY B 191 LEU B 188 GLY B 187 LEU B 185	None	0.88A	6mdqA-5a8rB: undetectable	6mdqA-5a8rB: 10.23