SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 9 VAL A  59
VAL A  52
LEU A 106
ILE A 212
LEU A  33
 None
 1.05A 1eqgA-5a8zA:
undetectable		 1eqgA-5a8zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 11 VAL A  59
VAL A  52
LEU A 106
ILE A 212
LEU A  33
 None
 1.06A 1eqgB-5a8zA:
undetectable		 1eqgB-5a8zA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_0
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLY A 140
SER A  32
SER A 195
ALA A 138
ILE A  16
 None
None
IUL  A1001 (-3.3A)
None
None
 1.16A 1nt2A-5a8zA:
undetectable		 1nt2A-5a8zA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLY A 140
PHE A  41
GLY A 193
GLY A 142
ALA A 152
 None
 1.09A 2dpmA-5a8zA:
undetectable		 2dpmA-5a8zA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_B_J01B600_1
(ORF12)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 11 ALA A 213
TYR A  94
ALA A  55
GLY A 196
SER A 195
 IUL  A1001 (-3.6A)
IUL  A1001 (-4.7A)
None
None
IUL  A1001 (-3.3A)
 1.41A 2xfsB-5a8zA:
undetectable		 2xfsB-5a8zA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.10A 3kvvA-5a8zA:
undetectable		 3kvvA-5a8zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.11A 3kvvC-5a8zA:
undetectable		 3kvvC-5a8zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.05A 3kvvD-5a8zA:
undetectable		 3kvvD-5a8zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.06A 3kvvE-5a8zA:
undetectable		 3kvvE-5a8zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.09A 3kvvF-5a8zA:
undetectable		 3kvvF-5a8zA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLN A 233
VAL A 181
LEU A 199
THR A  45
ILE A  47
 None
 1.38A 3mnoA-5a8zA:
undetectable		 3mnoA-5a8zA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLN A 233
VAL A 181
LEU A 199
THR A  45
ILE A  47
 None
 1.38A 3mnpA-5a8zA:
undetectable		 3mnpA-5a8zA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA401_2
(HIV-1 PROTEASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 7 VAL A  59
ILE A 105
VAL A  31
VAL A  66
 None
 0.80A 3ufnB-5a8zA:
undetectable		 3ufnB-5a8zA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 7 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.08A 4e1vB-5a8zA:
undetectable		 4e1vB-5a8zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 6 GLY A 211
MET A 139
ILE A 212
VAL A 231
 None
 1.10A 4e1vF-5a8zA:
undetectable		 4e1vF-5a8zA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 8 ILE A 114
PRO A 198
VAL A  31
MET A  53
 None
 1.33A 4f4dB-5a8zA:
undetectable		 4f4dB-5a8zA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 ALA A 188
GLY A  18
GLY A  19
ASN A 159
GLY A 186
 None
None
None
NAG  A 401 (-1.8A)
None
 0.99A 4obwB-5a8zA:
undetectable		 4obwB-5a8zA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 5 PHE A 228
PRO A 230
VAL A 181
ALA A 227
 None
 1.25A 4w5oA-5a8zA:
undetectable		 4w5oA-5a8zA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 5 PHE A 228
PRO A 230
VAL A 181
ALA A 227
 None
 1.28A 4z4cA-5a8zA:
undetectable		 4z4cA-5a8zA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 5 PHE A 228
PRO A 230
VAL A 181
ALA A 227
 None
 1.27A 4z4dA-5a8zA:
undetectable		 4z4dA-5a8zA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		4 / 5 PHE A 228
PRO A 230
VAL A 181
ALA A 227
 None
 1.25A 4z4eA-5a8zA:
undetectable		 4z4eA-5a8zA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLY A 207
LEU A 155
TRP A  27
PHE A  29
THR A  45
 FUC  A 402 (-3.7A)
None
None
None
None
 1.44A 5nknA-5a8zA:
undetectable		 5nknA-5a8zA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 9 LEU A 123
ILE A 103
PHE A 234
MET A  53
ILE A 212
 None
 1.20A 5yf9X-5a8zA:
undetectable		 5yf9X-5a8zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		5 / 12 GLY A 196
ALA A  44
ALA A 229
ALA A  55
ALA A  56
 None
 1.07A 5zw4A-5a8zA:
undetectable		 5zw4A-5a8zA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 5a8z NEUTROPHIL ELASTASE
(Homo
sapiens) 		3 / 3 VAL A  67
ALA A  70
GLN A  34
 None
 0.63A 6gb9A-5a8zA:
undetectable		 6gb9A-5a8zA:
18.72