SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a9d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_C_ZPCC1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	5a9d	SOLUTE CARRIER FAMILY 15 MEMBER 1 (Mus musculus)	5 / 12	PHE A 455 VAL A 451 ILE A 440 HIS A 461 VAL A 465	None	1.27A	4a97B-5a9dA: undetectable 4a97C-5a9dA: undetectable	4a97B-5a9dA: 20.58 4a97C-5a9dA: 20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_A_BEZA301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	5a9d	SOLUTE CARRIER FAMILY 15 MEMBER 1 (Mus musculus)	5 / 10	GLY A 525 SER A 547 LEU A 549 GLU A 571 TYR A 529	None	1.35A	5hwkA-5a9dA: undetectable	5hwkA-5a9dA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HWK_B_BEZB301_0 (GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOT RANSFERASE)	5a9d	SOLUTE CARRIER FAMILY 15 MEMBER 1 (Mus musculus)	5 / 10	GLY A 525 SER A 547 LEU A 549 GLU A 571 TYR A 529	None	1.34A	5hwkB-5a9dA: undetectable	5hwkB-5a9dA: 23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D6T_D_FYPD406_0 (GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOB UTYRIC ACID RECEPTOR SUBUNIT ALPHA-1 HUMAN GABA-A RECEPTOR SUBUNIT GAMMA-2)	5a9d	SOLUTE CARRIER FAMILY 15 MEMBER 1 (Mus musculus)	5 / 11	HIS A 459 SER A 517 TYR A 508 ASP A 574 ALA A 554	GOL A1582 (-3.9A) None None None None	1.28A	6d6tD-5a9dA: undetectable 6d6tE-5a9dA: undetectable	6d6tD-5a9dA: 20.33 6d6tE-5a9dA: 17.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4A97_C_ZPCC1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","5a9d","SOLUTE CARRIER FAMILY 15 MEMBER 1","Mus musculus",5,"PHE A 455;VAL A 451;ILE A 440;HIS A 461;VAL A 465","None","1.27A","4a97B-5a9dA:undetectable;4a97C-5a9dA:undetectable","4a97B-5a9dA:20.58;4a97C-5a9dA:20.58"],["5HWK_A_BEZA301_0","GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE","5a9d","SOLUTE CARRIER FAMILY 15 MEMBER 1","Mus musculus",5,"GLY A 525;SER A 547;LEU A 549;GLU A 571;TYR A 529","None","1.35A","5hwkA-5a9dA:undetectable","5hwkA-5a9dA:23.75"],["5HWK_B_BEZB301_0","GLUTATHIONE-SPECIFIC GAMMA-GLUTAMYLCYCLOTRANSFERASE","5a9d","SOLUTE CARRIER FAMILY 15 MEMBER 1","Mus musculus",5,"GLY A 525;SER A 547;LEU A 549;GLU A 571;TYR A 529","None","1.34A","5hwkB-5a9dA:undetectable","5hwkB-5a9dA:23.75"],["6D6T_D_FYPD406_0","GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1,GAMMA-AMINOBUTYRIC ACID RECEPTOR SUBUNIT ALPHA-1;HUMAN GABA-A RECEPTOR SUBUNIT GAMMA-2","5a9d","SOLUTE CARRIER FAMILY 15 MEMBER 1","Mus musculus",5,"HIS A 459;SER A 517;TYR A 508;ASP A 574;ALA A 554","GOL A1582 (-3.9A);None;None;None;None","1.28A","6d6tD-5a9dA:undetectable;6d6tE-5a9dA:undetectable","6d6tD-5a9dA:20.33;6d6tE-5a9dA:17.91"]]