SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a9i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 7 VAL A 584
VAL A 503
LEU A 502
LEU A 582
 None
 0.82A 1pthA-5a9iA:
undetectable		 1pthA-5a9iA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 7 VAL A 584
VAL A 503
LEU A 502
LEU A 582
 None
 0.81A 1pthB-5a9iA:
undetectable		 1pthB-5a9iA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		5 / 6 LEU A 572
TYR A 556
ILE A 529
ILE A 517
ARG A 549
 None
 0.87A 2q8hA-5a9iA:
undetectable		 2q8hA-5a9iA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		5 / 12 ILE A 517
LEU A 537
ASN A 528
VAL A 551
VAL A 559
 None
 1.09A 2vn0A-5a9iA:
undetectable		 2vn0A-5a9iA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 6 GLU A 564
LYS A 525
ASP A 526
ASP A 542
 None
 1.43A 3pocB-5a9iA:
undetectable		 3pocB-5a9iA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		3 / 3 LEU A 490
HIS A 492
MET A 501
 None
 0.75A 3thrD-5a9iA:
undetectable		 3thrD-5a9iA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 5 ARG A 549
VAL A 539
LEU A 527
SER A 538
 None
 1.30A 4e1gA-5a9iA:
undetectable		 4e1gA-5a9iA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		6 / 12 VAL A 539
LEU A 593
PHE A 519
LEU A 531
VAL A 551
THR A 522
 None
 1.44A 4eckA-5a9iA:
undetectable		 4eckA-5a9iA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 6 HIS A 451
ASN A 420
VAL A 428
LEU A 439
 None
 1.50A 5xdhA-5a9iA:
undetectable
5xdhC-5a9iA:
undetectable		 5xdhA-5a9iA:
19.68
5xdhC-5a9iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 5 HIS A 451
ASN A 420
VAL A 428
LEU A 439
 None
 1.39A 5xdhB-5a9iA:
undetectable		 5xdhB-5a9iA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5a9i SOLUTE CARRIER
FAMILY 15 MEMBER 2
(Rattus
norvegicus) 		4 / 5 HIS A 451
ASN A 420
VAL A 428
LEU A 439
 None
 1.39A 5xdhD-5a9iA:
undetectable		 5xdhD-5a9iA:
19.68