SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5a9t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJ6_B_AZMB401_1
(CARBONIC ANHYDRASE
XIV)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 10 HIS A  29
VAL A  66
LEU A  94
LEU A 151
THR A 150
 None
 1.07A 1rj6B-5a9tA:
undetectable		 1rj6B-5a9tA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 8 HIS A  29
VAL A  66
LEU A 151
THR A 150
 None
 0.87A 2gehA-5a9tA:
undetectable		 2gehA-5a9tA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 12 LEU A  79
LEU A  86
ASN A  93
THR A  98
VAL A  91
 None
 1.22A 3dcjA-5a9tA:
5.4
3dcjB-5a9tA:
4.9		 3dcjA-5a9tA:
25.89
3dcjB-5a9tA:
25.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 7 TYR A  76
LEU A  79
LEU A  69
ASP A  73
 None
 1.03A 3lm8A-5a9tA:
2.6
3lm8C-5a9tA:
2.3		 3lm8A-5a9tA:
21.36
3lm8C-5a9tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 8 ASP A  73
TYR A  76
LEU A  79
LEU A  69
 None
 0.90A 3lm8B-5a9tA:
2.4
3lm8D-5a9tA:
3.0		 3lm8B-5a9tA:
21.36
3lm8D-5a9tA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 4 TRP A  34
LEU A  79
LEU A  65
THR A   9
 None
 1.18A 4bboD-5a9tA:
undetectable		 4bboD-5a9tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 12 GLY A  12
GLY A  14
PRO A  15
ASN A  95
LEU A  69
 None
 0.77A 4gc9A-5a9tA:
4.3		 4gc9A-5a9tA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 11 HIS A  29
VAL A  66
LEU A  94
LEU A 151
THR A 150
 None
 1.14A 4lu3A-5a9tA:
undetectable		 4lu3A-5a9tA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 5 GLY A 278
TYR A 231
SER A 284
GLU A 239
 None
 1.28A 4xueA-5a9tA:
5.2		 4xueA-5a9tA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 5 GLY A 278
TYR A 231
SER A 284
GLU A 279
 None
 1.21A 4xueA-5a9tA:
5.2		 4xueA-5a9tA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 11 LEU A  65
VAL A  67
LEU A  24
GLY A  17
SER A  62
 None
 1.30A 4zbqA-5a9tA:
undetectable		 4zbqA-5a9tA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 8 LEU A 117
ILE A 121
ALA A 120
LEU A  94
 None
 0.68A 5te8B-5a9tA:
undetectable		 5te8B-5a9tA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 10 HIS A  29
VAL A  66
LEU A 151
THR A 150
PRO A 157
 None
 1.31A 5tt3A-5a9tA:
undetectable		 5tt3A-5a9tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		5 / 10 HIS A  29
VAL A  66
LEU A 151
THR A 150
PRO A 157
 None
 1.28A 5tt3C-5a9tA:
undetectable		 5tt3C-5a9tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 8 HIS A  29
VAL A  66
LEU A 151
THR A 150
 None
 0.84A 5tt3F-5a9tA:
undetectable		 5tt3F-5a9tA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7J_A_TESA502_0
(CYTOCHROME P450)		 5a9t PUTATIVE
DEHYDROGENASE
(Amycolatopsis
orientalis) 		4 / 7 LEU A  75
LEU A  69
ALA A  11
THR A   9
 None
 0.83A 6a7jA-5a9tA:
undetectable		 6a7jA-5a9tA:
13.79