SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aa4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PB9_A_4AXA901_1
(N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT 1)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 9 LEU B 110
THR B 111
SER B 159
SER B 160
ASP B 203
 None
 0.77A 1pb9A-5aa4B:
21.6		 1pb9A-5aa4B:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 10 ALA B 104
ALA B 106
LEU B 110
LEU B  93
LEU B  45
 None
 1.05A 2bxqA-5aa4B:
undetectable		 2bxqA-5aa4B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 6 LEU B 201
THR B 200
ARG B 227
LEU B 207
 None
 1.12A 2wm3A-5aa4B:
undetectable		 2wm3A-5aa4B:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		3 / 3 ARG B 190
VAL B 202
THR B 200
 None
 0.84A 3cyxA-5aa4B:
undetectable		 3cyxA-5aa4B:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 6 ASN B 246
LEU B 249
ASP B 250
LYS B 253
 None
 1.16A 3lslG-5aa4B:
22.6		 3lslG-5aa4B:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 4 ASN B  51
SER B 159
LEU B 156
THR B  86
 None
 1.15A 4an2A-5aa4B:
undetectable		 4an2A-5aa4B:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		3 / 3 LEU B 189
MET B 154
TYR B 135
 None
 0.84A 4p6xG-5aa4B:
undetectable		 4p6xG-5aa4B:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 6 GLU B  67
TYR B 126
LEU B 258
PHE B  66
 None
 1.28A 4twdF-5aa4B:
undetectable
4twdG-5aa4B:
undetectable		 4twdF-5aa4B:
20.29
4twdG-5aa4B:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 8 GLY B 432
GLN B  58
ASN B  51
HIS B 392
 None
 0.97A 4wryA-5aa4B:
undetectable		 4wryA-5aa4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		4 / 8 GLY B 432
GLN B  58
ASN B  51
HIS B 392
 None
 0.97A 4wrzA-5aa4B:
undetectable		 4wrzA-5aa4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 12 LYS B 352
ILE B 355
GLN B 356
SER B 359
PHE B 295
 None
 1.28A 5hgcA-5aa4B:
undetectable		 5hgcA-5aa4B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA705_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 9 ALA B 252
GLN B 251
PHE B 248
GLU B  76
LEU B  70
 None
 1.39A 5i73A-5aa4B:
undetectable		 5i73A-5aa4B:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND2_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 12 LEU B  82
SER B 123
PHE B  74
ARG B  46
LEU B 241
 None
 1.09A 5nd2B-5aa4B:
undetectable		 5nd2B-5aa4B:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_0
(SERUM ALBUMIN)		 5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F
(Pseudomonas
aeruginosa) 		5 / 12 LYS B 414
VAL B 413
LEU B 393
GLY B 313
LEU B 308
 None
 1.24A 6a7pA-5aa4B:
undetectable		 6a7pA-5aa4B:
20.23