SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aa5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 7 TYR C 465
GLU C 473
TRP C 110
PHE C 296
 None
 1.18A 1b2iA-5aa5C:
undetectable		 1b2iA-5aa5C:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB6_0
(GRAMICIDIN A)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 TRP C 272
ALA C 401
VAL C 301
 None
 0.93A 1bdwA-5aa5C:
undetectable
1bdwB-5aa5C:
undetectable		 1bdwA-5aa5C:
3.78
1bdwB-5aa5C:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 VAL C 313
TRP C 272
TRP C 378
 None
 1.21A 1c4dA-5aa5C:
undetectable
1c4dB-5aa5C:
undetectable		 1c4dA-5aa5C:
3.78
1c4dB-5aa5C:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 VAL C 313
TRP C 378
TRP C 272
 None
 1.44A 1c4dA-5aa5C:
undetectable
1c4dB-5aa5C:
undetectable		 1c4dA-5aa5C:
3.78
1c4dB-5aa5C:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		3 / 3 GLU A 127
ILE A 123
ARG C 364
 None
 0.82A 1cd2A-5aa5A:
undetectable		 1cd2A-5aa5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 8 TYR A 148
ASP A 214
LEU A 217
LEU A 213
 None
 0.96A 1e7cA-5aa5A:
undetectable		 1e7cA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		3 / 3 PHE C  58
TRP A 110
GLU A 102
 None
 1.10A 1mogA-5aa5C:
undetectable		 1mogA-5aa5C:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 287
PRO A 184
GLY A 185
GLY A 150
GLY A 149
 SF4  A 502 ( 4.1A)
None
None
None
None
 1.05A 1mxdA-5aa5A:
undetectable		 1mxdA-5aa5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 7 TYR A 109
ASN C 369
TYR C 328
GLY C 324
 None
 1.03A 1mxgA-5aa5A:
undetectable		 1mxgA-5aa5A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NB9_A_RBFA401_1
(HYPOTHETICAL PROTEIN
FLJ11149)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 THR A  40
ILE C  83
LEU C 131
ILE C 126
ASP C 123
 None
 1.21A 1nb9A-5aa5A:
undetectable		 1nb9A-5aa5A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 7 VAL C 262
GLY C 263
ASP C 135
ILE C 561
 None
 0.72A 1p2yA-5aa5C:
undetectable		 1p2yA-5aa5C:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 TYR A 167
ASP A 130
LEU A 168
ILE A  26
ILE A 123
 None
 1.39A 1q6iA-5aa5A:
undetectable		 1q6iA-5aa5A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT0_C_ACTC6901_0
(PYRANOSE OXIDASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 THR C 186
GLN C 456
PHE C 237
HIS C 245
 None
 1.49A 1tt0C-5aa5C:
undetectable		 1tt0C-5aa5C:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 4 GLY A 149
SER A  98
ILE A 151
HIS A 152
 None
None
SF4  A 503 ( 4.7A)
SF4  A 503 ( 4.7A)
 1.37A 1yajJ-5aa5A:
undetectable		 1yajJ-5aa5A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 8 GLN A 263
PHE A 223
ASN A 182
ASP A 214
 None
 1.33A 1zzqA-5aa5A:
undetectable		 1zzqA-5aa5A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.15A 2bm9A-5aa5A:
undetectable		 2bm9A-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.05A 2br4A-5aa5A:
undetectable		 2br4A-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		6 / 12 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
ALA A 142
 None
 1.46A 2br4D-5aa5A:
undetectable		 2br4D-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.05A 2br4E-5aa5A:
undetectable		 2br4E-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A 129
LEU A 168
GLY A 163
TYR A 167
ALA A 146
 None
 1.12A 2br4F-5aa5A:
undetectable		 2br4F-5aa5A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_A_P1ZA2001_1
(SERUM ALBUMIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A  93
LEU A 129
ALA A 165
ILE A 180
ALA A 146
 None
 1.00A 2bxcA-5aa5A:
undetectable		 2bxcA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A  93
LEU A 129
LEU A 168
ALA A 165
ALA A 146
 None
 1.16A 2bxpA-5aa5A:
undetectable		 2bxpA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D06_B_ESTB305_1
(SULFOTRANSFERASE 1A1)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 10 PRO C 352
HIS C 351
ALA C  95
TYR C 285
MET C  98
 None
 1.39A 2d06B-5aa5C:
undetectable		 2d06B-5aa5C:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 TYR C 285
LEU C 312
HIS C 351
ILE C 319
SER C 505
 None
 1.30A 2efjA-5aa5C:
undetectable		 2efjA-5aa5C:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 7 TYR C 259
GLY C 263
THR C 547
ASN C 444
 None
 1.09A 2g70A-5aa5C:
undetectable		 2g70A-5aa5C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 7 TYR C 259
GLY C 263
THR C 547
ASN C 444
 None
 1.08A 2g70B-5aa5C:
undetectable		 2g70B-5aa5C:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_B_017B203_1
(PROTEASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 6 PRO A 134
LEU A 168
ARG A 175
GLY A 177
 None
 1.12A 2hs2B-5aa5A:
undetectable		 2hs2B-5aa5A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 MET C 172
ASP C 246
ASP C 247
TYR C 165
 None
 1.47A 2lh8A-5aa5C:
2.0		 2lh8A-5aa5C:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 12 LEU A  95
ALA A 146
LEU A 168
LEU A 217
THR A 196
 None
 1.25A 2oaxF-5aa5A:
undetectable		 2oaxF-5aa5A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 TRP C 272
GLY C 394
GLY C 393
ASN C 527
 None
 0.97A 2qr2A-5aa5C:
undetectable
2qr2B-5aa5C:
undetectable		 2qr2A-5aa5C:
18.51
2qr2B-5aa5C:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 0.86A 2rlfA-5aa5C:
undetectable
2rlfB-5aa5C:
undetectable		 2rlfA-5aa5C:
6.54
2rlfB-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 1.09A 2rlfB-5aa5C:
undetectable
2rlfC-5aa5C:
undetectable		 2rlfB-5aa5C:
6.54
2rlfC-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 LEU C 269
LEU C 268
ASP C 390
ILE C 396
 None
 0.94A 2rlfC-5aa5C:
undetectable
2rlfD-5aa5C:
undetectable		 2rlfC-5aa5C:
6.54
2rlfD-5aa5C:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 10 GLY C 270
ALA C 401
PHE C 496
LEU C 312
THR C 309
 None
 1.24A 3a3yA-5aa5C:
undetectable		 3a3yA-5aa5C:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 8 GLY A 106
ASN A 105
TRP C 372
PHE C 327
 None
 0.92A 3ccfA-5aa5A:
undetectable		 3ccfA-5aa5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 ASN C 125
HIS C 124
VAL C 500
 None
None
NFU  C 701 (-3.9A)
 0.86A 3elzB-5aa5C:
undetectable		 3elzB-5aa5C:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		3 / 3 SER A  38
ASP A  35
ASP A 191
 None
SF4  A 503 (-2.2A)
None
 0.93A 3iv6C-5aa5A:
undetectable		 3iv6C-5aa5A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A  31
PHE C  75
PHE A 300
GLY A 150
PHE A 293
 SF4  A 503 (-3.5A)
None
None
None
None
 1.22A 3ko0A-5aa5A:
undetectable
3ko0C-5aa5A:
undetectable		 3ko0A-5aa5A:
16.41
3ko0C-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 150
PHE A 293
GLY A  31
PHE C  75
PHE A 300
 None
None
SF4  A 503 (-3.5A)
None
None
 1.26A 3ko0F-5aa5A:
undetectable
3ko0G-5aa5A:
undetectable		 3ko0F-5aa5A:
16.41
3ko0G-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_G_TFPG201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 150
PHE A 293
GLY A  97
PHE C  75
PHE A 300
 None
None
SF4  A 503 ( 4.3A)
None
None
 1.34A 3ko0F-5aa5A:
undetectable
3ko0G-5aa5A:
undetectable		 3ko0F-5aa5A:
16.41
3ko0G-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 150
PRO A 294
GLY A  31
PHE C  75
PHE A 300
 None
None
SF4  A 503 (-3.5A)
None
None
 1.19A 3ko0H-5aa5A:
undetectable
3ko0I-5aa5A:
undetectable		 3ko0H-5aa5A:
16.41
3ko0I-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 150
PRO A 294
GLY A  97
PHE C  75
PHE A 300
 None
None
SF4  A 503 ( 4.3A)
None
None
 1.23A 3ko0H-5aa5A:
undetectable
3ko0I-5aa5A:
undetectable		 3ko0H-5aa5A:
16.41
3ko0I-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 9 GLY A 150
PRO A 294
ILE C  80
PHE C  75
PHE A 300
 None
 1.39A 3ko0H-5aa5A:
undetectable
3ko0I-5aa5A:
undetectable		 3ko0H-5aa5A:
16.41
3ko0I-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR201_1
(PROTEIN S100-A4)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		5 / 10 GLY A 149
ILE C  76
PHE A 293
GLY A 292
PHE A 297
 None
 1.47A 3ko0R-5aa5A:
undetectable
3ko0T-5aa5A:
undetectable		 3ko0R-5aa5A:
16.41
3ko0T-5aa5A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 5 TYR C 183
ILE A  23
LEU A  63
PHE C 178
 None
 1.18A 3ls4L-5aa5C:
undetectable		 3ls4L-5aa5C:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 PHE C 550
PHE C 570
ILE C 563
ALA C 543
THR C 547
 None
 0.98A 3ndiA-5aa5C:
undetectable		 3ndiA-5aa5C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 PHE C 550
TYR C 259
PHE C 570
ALA C 543
THR C 547
 None
 1.27A 3ndiA-5aa5C:
undetectable		 3ndiA-5aa5C:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P97_C_SAMC263_0
(NON-STRUCTURAL
PROTEIN 5)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		6 / 12 GLY A  29
GLY A  34
GLY A  97
ASP C  86
VAL C 205
ASP A  33
 None
SF4  A 503 ( 3.8A)
SF4  A 503 ( 4.3A)
None
None
None
 1.42A 3p97C-5aa5A:
undetectable		 3p97C-5aa5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL6_A_NIMA614_1
(LACTOPEROXIDASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 7 GLN C 355
HIS C 519
PHE C  58
PRO A 158
 None
 1.09A 3ql6A-5aa5C:
undetectable		 3ql6A-5aa5C:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 GLY C 270
PRO C 523
GLY C 502
LEU C 387
ASP C 380
 None
NFU  C 701 (-3.3A)
None
None
None
 1.40A 3r24A-5aa5C:
undetectable		 3r24A-5aa5C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 8 GLY C  85
TYR C  61
PRO C 520
ARG C  59
 None
 1.02A 3s3nA-5aa5C:
undetectable		 3s3nA-5aa5C:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 SER C  56
LEU C  35
THR C  54
ARG C 364
 None
 1.46A 3thrB-5aa5C:
undetectable		 3thrB-5aa5C:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 6 GLY C  33
VAL C  32
ASP A  33
THR A  27
 None
 1.23A 3vqrA-5aa5C:
undetectable		 3vqrA-5aa5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 5 GLY C  33
VAL C  32
ASP A  33
THR A  27
 None
 1.23A 3vqrB-5aa5C:
undetectable		 3vqrB-5aa5C:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 8 TYR C 328
TRP C 372
ARG C  59
LEU A  30
 None
 1.30A 3wipG-5aa5C:
undetectable
3wipH-5aa5C:
undetectable		 3wipG-5aa5C:
17.79
3wipH-5aa5C:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 7 LEU C 187
VAL A  51
LEU A  68
TYR C 183
 None
 0.91A 4b3qA-5aa5C:
undetectable		 4b3qA-5aa5C:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 7 TRP C 272
GLY C 394
GLY C 393
ASN C 527
 None
 0.98A 4fgkB-5aa5C:
undetectable		 4fgkB-5aa5C:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 THR C 524
GLY C 577
PRO C 575
GLY C  82
 NFU  C 701 (-3.8A)
None
None
None
 0.84A 4fjpA-5aa5C:
undetectable		 4fjpA-5aa5C:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 11 PHE C 435
GLN C 456
ALA C 457
ALA C 460
ALA C 461
 None
 1.09A 4j6cA-5aa5C:
undetectable		 4j6cA-5aa5C:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 7 GLN A 263
PHE A 223
ASN A 182
ASP A 214
 None
 1.45A 4kcnB-5aa5A:
undetectable		 4kcnB-5aa5A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAE_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 PHE C 182
TYR C 165
LEU C 244
THR C 453
 None
 1.34A 4paeA-5aa5C:
0.0		 4paeA-5aa5C:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 6 LEU A 217
LEU A 178
THR A 196
VAL A 183
 None
 1.07A 4udaA-5aa5A:
undetectable		 4udaA-5aa5A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_2
(CYTOCHROME P450 2D6)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		3 / 3 GLU C 261
ILE C 267
ALA C 543
 None
 0.62A 4wnwB-5aa5C:
undetectable		 4wnwB-5aa5C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		3 / 3 VAL A  67
PHE C 127
ARG C 501
 None
None
NFU  C 701 (-4.6A)
 0.80A 4xr4B-5aa5A:
undetectable		 4xr4B-5aa5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 7 ILE C  57
LEU A  30
GLY A  97
GLY A  29
 None
None
SF4  A 503 ( 4.3A)
None
 0.73A 5a06B-5aa5C:
undetectable		 5a06B-5aa5C:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_E_LFXE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 5 SER C 190
GLY A  34
THR A  27
GLU A  96
 None
SF4  A 503 ( 3.8A)
None
None
 1.18A 5btiA-5aa5C:
undetectable
5btiB-5aa5C:
undetectable		 5btiA-5aa5C:
21.43
5btiB-5aa5C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTI_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 5 SER C 190
GLY A  34
THR A  27
GLU A  96
 None
SF4  A 503 ( 3.8A)
None
None
 1.21A 5btiC-5aa5C:
undetectable
5btiD-5aa5C:
undetectable		 5btiC-5aa5C:
21.43
5btiD-5aa5C:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E9Q_C_SAMC4000_0
(GENOME POLYPROTEIN)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		6 / 12 GLY A  29
GLY A  34
GLY A  97
ASP C  86
VAL C 205
ASP A  33
 None
SF4  A 503 ( 3.8A)
SF4  A 503 ( 4.3A)
None
None
None
 1.46A 5e9qC-5aa5A:
undetectable		 5e9qC-5aa5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		6 / 12 GLY A  29
GLY A  34
GLY A  97
ASP C  86
VAL C 205
ASP A  33
 None
SF4  A 503 ( 3.8A)
SF4  A 503 ( 4.3A)
None
None
None
 1.38A 5eiwC-5aa5A:
undetectable		 5eiwC-5aa5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
(Cupriavidus
necator) 		4 / 8 THR A  27
ILE C  57
PRO A 100
LEU A  30
 None
 0.95A 5g48A-5aa5A:
undetectable		 5g48A-5aa5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		6 / 12 ARG C 531
VAL C 373
ALA C 528
THR C 524
GLY C  36
GLY C  33
 None
None
None
NFU  C 701 (-3.8A)
None
None
 1.20A 5h2uA-5aa5C:
undetectable		 5h2uA-5aa5C:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 LEU C 268
PRO C 539
GLY C 393
ASP C 571
ARG C 501
 None
None
None
None
NFU  C 701 (-4.6A)
 1.09A 5h5fA-5aa5C:
undetectable		 5h5fA-5aa5C:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_A_SAMA301_0
(NS5)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		6 / 12 GLY C  82
HIS C  88
ASP C  86
VAL C 205
ASP A  33
ILE C  83
 None
NFU  C 701 (-3.6A)
None
None
None
None
 1.38A 5njvA-5aa5C:
undetectable		 5njvA-5aa5C:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OAJ_E_TKTE601_1
()		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 8 GLU C 116
CYH C 576
CYH C  81
ARG C 501
 None
NFU  C 701 (-2.2A)
NFU  C 701 (-2.2A)
NFU  C 701 (-4.6A)
 1.05A 5oajD-5aa5C:
undetectable
5oajE-5aa5C:
undetectable		 5oajD-5aa5C:
17.18
5oajE-5aa5C:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA504_1
(CYTOCHROME P450 2C9)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 8 PHE C 252
ILE C 446
PHE C 136
PRO C 243
 None
 1.07A 5x23A-5aa5C:
undetectable		 5x23A-5aa5C:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		3 / 3 ARG C 203
PHE A 293
ARG C  79
 SF4  A 502 (-3.5A)
None
None
 1.01A 5y9yA-5aa5C:
undetectable		 5y9yA-5aa5C:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 6 ARG C 203
GLY A 277
THR C 209
VAL A 281
 SF4  A 502 (-3.5A)
None
None
None
 1.01A 5ysiA-5aa5C:
undetectable		 5ysiA-5aa5C:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		4 / 6 TYR C 253
ILE C 446
GLU C 447
ARG C 450
 None
 0.98A 5z3jA-5aa5C:
undetectable		 5z3jA-5aa5C:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		3 / 3 MET A  77
ASP C  26
ARG C 568
 None
 1.10A 5z6jA-5aa5A:
undetectable		 5z6jA-5aa5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		3 / 3 MET A  77
ASP C  26
ARG C 568
 None
 1.17A 5z6kA-5aa5A:
undetectable		 5z6kA-5aa5A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 PRO C 207
GLY C 202
ASP C  69
PRO C 212
TYR C 100
 None
 1.10A 5zvgA-5aa5C:
undetectable		 5zvgA-5aa5C:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA606_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK
NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator;
Cupriavidus
necator) 		4 / 5 GLU A  71
PHE A  76
HIS A  64
THR C  29
 None
 1.49A 6b58A-5aa5A:
undetectable		 6b58A-5aa5A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_N_PCFN606_0
(CYTOCHROME B)		 5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
(Cupriavidus
necator) 		5 / 12 MET C 564
ALA C 566
THR C 391
VAL C 544
VAL C  48
 None
 1.26A 6hu9N-5aa5C:
2.9		 6hu9N-5aa5C:
22.01