SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aa6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 ALA A 576
GLY A 337
TYR A 339
GLN A 345
HIS A 355
 None
 1.30A 1brpA-5aa6A:
undetectable		 1brpA-5aa6A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 8 LEU A 459
PRO A 243
VAL A 239
GLY A 238
 None
 1.04A 1hrkB-5aa6A:
undetectable		 1hrkB-5aa6A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 5 SER A 481
ASN A 482
ALA A 484
ASP A 487
 None
 1.39A 1lqtA-5aa6A:
undetectable
1lqtB-5aa6A:
undetectable		 1lqtA-5aa6A:
22.55
1lqtB-5aa6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 5 SER A 481
ASN A 482
ALA A 484
ASP A 487
 None
 1.39A 1lquA-5aa6A:
undetectable
1lquB-5aa6A:
undetectable		 1lquA-5aa6A:
22.55
1lquB-5aa6A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_A_ADNA2001_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 7 TRP A 236
GLU A 546
ALA A 527
ALA A 452
 None
 0.82A 2ejfA-5aa6A:
undetectable		 2ejfA-5aa6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 11 PHE A 491
SER A 524
LEU A 231
ILE A 528
GLU A 518
 None
 1.21A 2v0mA-5aa6A:
undetectable		 2v0mA-5aa6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 8 TYR A 458
LEU A 459
LEU A 455
ALA A 545
 None
 0.94A 2wekA-5aa6A:
undetectable		 2wekA-5aa6A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 6 LEU A 307
ILE A 301
ARG A 322
VAL A 141
 None
 1.15A 2ygoA-5aa6A:
undetectable		 2ygoA-5aa6A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 7 TRP A 236
GLU A 546
ALA A 527
ALA A 452
 None
 0.79A 2zgwA-5aa6A:
0.4		 2zgwA-5aa6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 6 TRP A 236
GLU A 546
ALA A 527
ALA A 452
 None
 0.80A 2zgwB-5aa6A:
0.5		 2zgwB-5aa6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 ILE A  64
ILE A  66
ASP A 152
VAL A 151
GLY A  65
 None
 1.00A 3bwcA-5aa6A:
undetectable		 3bwcA-5aa6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 9 THR A 266
ALA A 264
LEU A 299
ASN A 303
ARG A 302
 None
 1.34A 3kp6B-5aa6A:
undetectable		 3kp6B-5aa6A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 THR A 523
ALA A 527
GLY A 238
SER A 246
SER A 216
 None
 1.11A 3mg02-5aa6A:
undetectable
3mg0V-5aa6A:
undetectable		 3mg02-5aa6A:
15.40
3mg0V-5aa6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_2_BO221405_1
(PROTEASOME COMPONENT
PRE3
PROTEASOME COMPONENT
PUP1)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 THR A 523
SER A 241
GLY A 238
SER A 246
SER A 216
 None
 1.10A 3mg02-5aa6A:
undetectable
3mg0V-5aa6A:
undetectable		 3mg02-5aa6A:
15.40
3mg0V-5aa6A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 GLY A 548
SER A 449
ALA A 457
TYR A 458
ASN A 454
 None
VO4  A 800 (-2.7A)
None
None
None
 1.34A 3t7sC-5aa6A:
undetectable		 3t7sC-5aa6A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEG_A_DAHA416_1
(PHENYLALANYL-TRNA
SYNTHETASE,
MITOCHONDRIAL)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 PHE A 312
GLY A 440
GLY A 534
ALA A 436
GLY A 438
 None
 1.13A 3tegA-5aa6A:
undetectable		 3tegA-5aa6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 8 VAL A 393
VAL A 407
ILE A 406
LEU A 167
 None
 0.87A 4jq1B-5aa6A:
undetectable		 4jq1B-5aa6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 10 VAL A 393
VAL A 407
ILE A 406
LEU A 381
LEU A 167
 None
 1.46A 4jtqA-5aa6A:
undetectable		 4jtqA-5aa6A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_2
(DIHYDROFOLATE
REDUCTASE)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		3 / 3 TRP A 280
GLN A 423
THR A 279
 None
 0.50A 4m2xA-5aa6A:
undetectable		 4m2xA-5aa6A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 9 ASP A 155
VAL A  73
ALA A  72
GLY A 153
GLY A  69
 None
 1.37A 4mmeA-5aa6A:
0.5		 4mmeA-5aa6A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 9 ASP A 155
VAL A  73
ALA A  72
GLY A 153
GLY A  69
 None
 1.30A 4mmfA-5aa6A:
undetectable		 4mmfA-5aa6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 9 ASP A 155
VAL A  73
ALA A  72
GLY A 153
GLY A  69
 None
 1.32A 4mmfB-5aa6A:
undetectable		 4mmfB-5aa6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 TYR A 583
LEU A 556
ALA A 464
PHE A 465
TYR A 458
 None
 1.21A 5ljbA-5aa6A:
undetectable		 5ljbA-5aa6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 TYR A 583
LEU A 556
ALA A 464
PHE A 465
TYR A 458
 None
 1.21A 5ljcA-5aa6A:
undetectable		 5ljcA-5aa6A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		3 / 3 GLY A  74
THR A  76
ASN A 158
 None
 0.65A 5odiG-5aa6A:
undetectable		 5odiG-5aa6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZWR_B_9KLB402_0
(EST-Y29)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		5 / 12 PHE A 580
ILE A 588
TYR A 583
LEU A 590
ALA A 552
 None
 1.35A 5zwrB-5aa6A:
undetectable		 5zwrB-5aa6A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2
(Ascophyllum
nodosum) 		4 / 4 LEU A 167
ASP A  83
GLN A  93
VAL A 430
 None
 1.38A 6bzoF-5aa6A:
0.6		 6bzoF-5aa6A:
21.69