SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aam'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 5aam SCFV513
(Mus
musculus) 		3 / 3 VAL A 161
TRP A 232
TRP A 100
 None
 1.41A 1c4dA-5aamA:
undetectable
1c4dB-5aamA:
undetectable		 1c4dA-5aamA:
3.60
1c4dB-5aamA:
3.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 5aam SCFV513
(Mus
musculus) 		5 / 12 TRP A  47
SER A  35
TYR A  33
GLY A 102
VAL A 230
 None
 1.32A 1vpoH-5aamA:
20.0
1vpoL-5aamA:
21.6		 1vpoH-5aamA:
33.73
1vpoL-5aamA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 5aam SCFV513
(Mus
musculus) 		4 / 8 THR A 210
SER A 199
THR A 208
SER A 201
 None
 0.93A 5l4eA-5aamA:
undetectable
5l4eB-5aamA:
undetectable
5l4eC-5aamA:
undetectable
5l4eD-5aamA:
undetectable
5l4eE-5aamA:
undetectable		 5l4eA-5aamA:
20.18
5l4eB-5aamA:
20.18
5l4eC-5aamA:
20.18
5l4eD-5aamA:
20.18
5l4eE-5aamA:
20.18