SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aao'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XL6_B_SPMB3001_1 (INWARD RECTIFIER POTASSIUM CHANNEL)	5aao	FAD3210 (synthetic construct)	4 / 5	ALA A 55 TYR A 57 ALA A 63 TYR A 59	None	1.11A	1xl6A-5aaoA: undetectable 1xl6B-5aaoA: undetectable	1xl6A-5aaoA: 19.80 1xl6B-5aaoA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W9G_A_TOPA1159_1 (DIHYDROFOLATE REDUCTASE)	5aao	FAD3210 (synthetic construct)	5 / 10	LEU A 60 ALA A 55 LEU A 51 VAL A 98 THR A 87	None	1.12A	2w9gA-5aaoA: undetectable	2w9gA-5aaoA: 23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WLK_B_SPMB1302_1 (ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10)	5aao	FAD3210 (synthetic construct)	4 / 4	ALA A 55 TYR A 57 ALA A 63 TYR A 59	None	1.11A	2wlkA-5aaoA: undetectable 2wlkB-5aaoA: undetectable	2wlkA-5aaoA: 19.80 2wlkB-5aaoA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3FRB_X_TOPX300_1 (DIHYDROFOLATE REDUCTASE)	5aao	FAD3210 (synthetic construct)	5 / 11	LEU A 60 ALA A 55 LEU A 51 VAL A 98 THR A 87	None	1.09A	3frbX-5aaoA: undetectable	3frbX-5aaoA: 21.91

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1XL6_B_SPMB3001_1","INWARD RECTIFIER POTASSIUM CHANNEL;INWARD RECTIFIER POTASSIUM CHANNEL","5aao","FAD3210","synthetic construct",4,"ALA A  55;TYR A  57;ALA A  63;TYR A  59","None","1.11A","1xl6A-5aaoA:undetectable;1xl6B-5aaoA:undetectable","1xl6A-5aaoA:19.80;1xl6B-5aaoA:19.80"],["2W9G_A_TOPA1159_1","DIHYDROFOLATE REDUCTASE","5aao","FAD3210","synthetic construct",5,"LEU A  60;ALA A  55;LEU A  51;VAL A  98;THR A  87","None","1.12A","2w9gA-5aaoA:undetectable","2w9gA-5aaoA:23.63"],["2WLK_B_SPMB1302_1","ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10;ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10","5aao","FAD3210","synthetic construct",4,"ALA A  55;TYR A  57;ALA A  63;TYR A  59","None","1.11A","2wlkA-5aaoA:undetectable;2wlkB-5aaoA:undetectable","2wlkA-5aaoA:19.80;2wlkB-5aaoA:19.80"],["3FRB_X_TOPX300_1","DIHYDROFOLATE REDUCTASE","5aao","FAD3210","synthetic construct",5,"LEU A  60;ALA A  55;LEU A  51;VAL A  98;THR A  87","None","1.09A","3frbX-5aaoA:undetectable","3frbX-5aaoA:21.91"]]