SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aar'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		5 / 12 ALA A 651
LEU A 631
LEU A 630
ILE A 610
GLY A 639
 None
 0.98A 3q95A-5aarA:
undetectable		 3q95A-5aarA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		3 / 3 LEU A 534
ARG A 552
ASN A 545
 None
 0.77A 3qxvD-5aarA:
undetectable		 3qxvD-5aarA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		3 / 3 ILE A 557
ASP A 548
ARG A 528
 None
 0.73A 4pstA-5aarA:
undetectable		 4pstA-5aarA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_1
(ESTROGEN RECEPTOR)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		5 / 12 ALA A 651
LEU A 631
LEU A 630
ILE A 610
GLY A 639
 None
 0.91A 4xi3B-5aarA:
undetectable		 4xi3B-5aarA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		5 / 11 ALA A 651
LEU A 631
LEU A 630
ILE A 610
GLY A 639
 None
 0.95A 5dxbB-5aarA:
undetectable		 5dxbB-5aarA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 5aar POTASSIUM CHANNEL
AKT1
(Arabidopsis
thaliana) 		3 / 3 ARG A 643
ARG A 580
ARG A 645
 None
 1.01A 5vcgA-5aarA:
undetectable		 5vcgA-5aarA:
16.08