SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ab4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 10 ALA A 388
PHE A 293
LEU A 218
VAL A 216
ILE A   8
 None
 1.28A 1claA-5ab4A:
undetectable		 1claA-5ab4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 ALA A  34
VAL A   9
GLY A  10
ALA A  97
HIS A 225
 None
 1.07A 1kxhA-5ab4A:
undetectable		 1kxhA-5ab4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		6 / 9 ALA A 277
PHE A 281
ALA A 310
LEU A 296
LEU A 389
PHE A 294
 None
 1.35A 1nr6A-5ab4A:
undetectable		 1nr6A-5ab4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 ILE A 291
ILE A  91
LEU A  94
VAL A 220
ILE A 247
 None
 1.06A 1oipA-5ab4A:
undetectable		 1oipA-5ab4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 5 PRO A 360
GLY A 392
ASN A 393
GLY A 394
 None
 1.12A 1zlqA-5ab4A:
undetectable		 1zlqA-5ab4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA501_1
(CYTOCHROME P450 2B4)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 7 MET A  40
LEU A  31
GLY A  12
ILE A 365
 None
 1.00A 2bdmA-5ab4A:
undetectable		 2bdmA-5ab4A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 11 ALA A 368
ILE A   8
ILE A 406
VAL A 402
VAL A 390
 None
 1.00A 2nnpB-5ab4A:
undetectable		 2nnpB-5ab4A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 7 LEU A 389
ALA A 310
GLY A 312
PHE A 294
PHE A 293
 None
 1.48A 2wq5A-5ab4A:
undetectable		 2wq5A-5ab4A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 8 ILE A 344
PRO A 343
VAL A 311
GLY A 312
 None
 0.81A 3em0B-5ab4A:
undetectable		 3em0B-5ab4A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 5 GLY A 319
LYS A 318
GLU A 321
GLY A 317
 None
 1.06A 3onnA-5ab4A:
undetectable		 3onnA-5ab4A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 GLY A 392
LEU A 296
GLU A 358
ALA A 361
ASN A 364
 None
 1.13A 3sxjA-5ab4A:
undetectable		 3sxjA-5ab4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 GLY A 392
LEU A 296
GLU A 358
ALA A 361
ASN A 364
 None
 1.13A 3sxjB-5ab4A:
undetectable		 3sxjB-5ab4A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 5 HIS A 347
GLY A 349
TYR A 363
GLU A 181
 None
 1.41A 4ae1B-5ab4A:
undetectable		 4ae1B-5ab4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		4 / 7 TYR A 327
ASN A 204
TYR A 188
GLU A 207
 None
 1.20A 4mi4A-5ab4A:
undetectable
4mi4C-5ab4A:
undetectable		 4mi4A-5ab4A:
22.43
4mi4C-5ab4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 VAL A 216
ALA A 215
GLY A  10
SER A  29
THR A 366
 None
 1.22A 4mm8A-5ab4A:
undetectable		 4mm8A-5ab4A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 6 ILE A 302
ALA A 200
THR A 203
VAL A 202
HIS A 145
 None
 1.28A 5eclD-5ab4A:
undetectable		 5eclD-5ab4A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ab4 SCP2-THIOLASE LIKE
PROTEIN
(Trypanosoma
brucei) 		5 / 12 PHE A 293
GLN A 371
HIS A 179
ILE A   8
HIS A 347
 None
 1.39A 6md4A-5ab4A:
undetectable		 6md4A-5ab4A:
10.87