SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aby'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		5 / 11 VAL A 180
LEU A 181
GLY A 178
ILE A 213
THR A 165
 None
 1.31A 3bjwE-5abyA:
undetectable		 3bjwE-5abyA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LPS_A_NOVA901_1
(TOPOISOMERASE IV
SUBUNIT B)		 5aby 4E-BINDING PROTEIN
MEXTLI
EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		5 / 12 SER A  59
GLU B 496
ARG B 499
PRO B 502
ILE B 504
 None
 1.39A 3lpsA-5abyA:
undetectable		 3lpsA-5abyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		3 / 3 ASN A  36
TRP A  38
ASP A 145
 None
 1.21A 4a7tA-5abyA:
undetectable
4a7tF-5abyA:
undetectable		 4a7tA-5abyA:
20.30
4a7tF-5abyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		5 / 12 LEU A 215
GLY A 178
GLN A 179
THR A 165
ILE A 147
 None
 1.31A 4oktA-5abyA:
undetectable		 4oktA-5abyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_1
(ANDROGEN RECEPTOR)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		5 / 12 LEU A 215
GLY A 178
GLN A 179
THR A 165
ILE A 147
 None
 1.28A 4okwA-5abyA:
undetectable		 4okwA-5abyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CR1_A_T44A201_1
(TRANSTHYRETIN)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		4 / 5 LEU A 185
ALA A 134
LEU A 181
VAL A 136
 None
 1.00A 5cr1A-5abyA:
undetectable		 5cr1A-5abyA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
(Caenorhabditis
elegans) 		5 / 12 ASN A 174
LEU A 175
GLY A 178
GLN A 179
VAL A 180
 None
 1.11A 5uc1B-5abyA:
undetectable		 5uc1B-5abyA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5aby EUKARYOTIC
TRANSLATION
INITIATION FACTOR
4E-3
4E-BINDING PROTEIN
MEXTLI
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		3 / 3 THR B 477
GLU A 130
ASN B 474
 None
 0.82A 6nj9K-5abyB:
undetectable		 6nj9K-5abyB:
7.71