SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aca'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_A_DVAA6_0
(GRAMICIDIN A)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 ALA 1  50
VAL 1 173
TRP 1  89
 None
 0.89A 1av2A-5aca1:
undetectable
1av2B-5aca1:
undetectable		 1av2A-5aca1:
10.61
1av2B-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 ALA 1  50
VAL 1 173
TRP 1  89
 None
 0.98A 1c4dA-5aca1:
undetectable
1c4dB-5aca1:
undetectable		 1c4dA-5aca1:
10.61
1c4dB-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 ALA 1  50
VAL 1 173
TRP 1  89
 None
 0.90A 1c4dC-5aca1:
undetectable
1c4dD-5aca1:
undetectable		 1c4dC-5aca1:
10.61
1c4dD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD6_0
(GRAMICIDIN A)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 1  89
ALA 1  50
VAL 1 173
 None
 0.91A 1c4dC-5aca1:
undetectable
1c4dD-5aca1:
undetectable		 1c4dC-5aca1:
10.61
1c4dD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 5aca VP1
VP2
VP3
(Foot-and-mouth
disease
virus) 		4 / 7 SER 1 127
HIS 1 123
SER 3 167
TYR 2 100
 None
 0.96A 1ibgL-5aca1:
undetectable		 1ibgL-5aca1:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 11 PHE 3  76
THR 3  74
VAL 3 203
VAL 3 122
VAL 3 188
 None
 1.17A 1phgA-5aca3:
undetectable		 1phgA-5aca3:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_A_DVAA6_0
(GRAMICIDIN D)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 ALA 1  50
VAL 1 173
TRP 1  89
 None
 0.86A 1w5uA-5aca1:
undetectable
1w5uB-5aca1:
undetectable		 1w5uA-5aca1:
10.61
1w5uB-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 1  89
ALA 1  50
VAL 1 173
 None
 0.96A 1w5uA-5aca1:
undetectable
1w5uB-5aca1:
undetectable		 1w5uA-5aca1:
10.61
1w5uB-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 8 TYR 1 130
ASN 1 131
GLU 1 133
GLY 1 132
 None
 0.96A 1ykiA-5aca1:
undetectable
1ykiB-5aca1:
undetectable		 1ykiA-5aca1:
18.88
1ykiB-5aca1:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 8 TYR 1 130
ASN 1 131
GLU 1 133
GLY 1 132
 None
 0.97A 1ykiA-5aca1:
undetectable
1ykiB-5aca1:
undetectable		 1ykiA-5aca1:
18.88
1ykiB-5aca1:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 8 TYR 1 130
ASN 1 131
GLU 1 133
GLY 1 132
 None
 0.91A 1ykiC-5aca1:
undetectable
1ykiD-5aca1:
undetectable		 1ykiC-5aca1:
18.88
1ykiD-5aca1:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 8 TYR 1 130
ASN 1 131
GLU 1 133
GLY 1 132
 None
 0.95A 1ykiC-5aca1:
undetectable
1ykiD-5aca1:
undetectable		 1ykiC-5aca1:
18.88
1ykiD-5aca1:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 5aca VP1
VP2
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 2 177
THR 1  70
TYR 1  71
 None
 1.22A 2a3aA-5aca2:
undetectable		 2a3aA-5aca2:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 5aca VP1
VP2
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 2 177
THR 1  70
TYR 1  71
 None
 1.26A 2a3bA-5aca2:
undetectable		 2a3bA-5aca2:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 5aca VP2
(Foot-and-mouth
disease
virus) 		4 / 5 LEU 2  81
PHE 2  62
VAL 2 107
ALA 2 202
 None
 1.11A 2cizA-5aca2:
undetectable		 2cizA-5aca2:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_D_DVAD6_0
(GRAMICIDIN D)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 1  89
ALA 1  50
VAL 1 173
 None
 0.82A 2izqC-5aca1:
undetectable
2izqD-5aca1:
undetectable		 2izqC-5aca1:
10.61
2izqD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5aca VP1
VP2
VP4
(Foot-and-mouth
disease
virus) 		4 / 5 LEU 2 142
LEU 4  71
CYH 1 192
THR 1  70
 None
 1.26A 2oaxD-5aca2:
undetectable		 2oaxD-5aca2:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5aca VP1
VP2
VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 8 HIS 1 123
SER 3 167
ASN 2 166
TYR 3 171
 None
 1.05A 2v57A-5aca1:
undetectable		 2v57A-5aca1:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 5aca VP1
VP2
VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 8 HIS 1 123
SER 3 167
ASN 2 166
TYR 3 171
 None
 1.06A 2v57C-5aca1:
undetectable		 2v57C-5aca1:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_1
(PHOSPHOLIPASE A2)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 5 VAL 1  35
VAL 1  32
THR 1  40
THR 1  30
 None
 1.16A 3bjwC-5aca1:
undetectable		 3bjwC-5aca1:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 5 VAL 1  35
VAL 1  32
THR 1  40
THR 1  30
 None
 1.23A 3bjwD-5aca1:
undetectable		 3bjwD-5aca1:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC552_1
(GLUTAMATE
DEHYDROGENASE)		 5aca VP2
VP3
(Foot-and-mouth
disease
virus) 		3 / 3 TYR 3 124
TYR 2 100
GLY 3 184
 None
 0.55A 3eteB-5aca3:
undetectable
3eteD-5aca3:
undetectable
3eteF-5aca3:
undetectable		 3eteB-5aca3:
17.80
3eteD-5aca3:
17.80
3eteF-5aca3:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5aca VP1
VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 11 TYR 3 171
THR 1 167
ASP 3  77
ALA 3  79
ASP 3 175
 None
 1.34A 3id5B-5aca3:
undetectable		 3id5B-5aca3:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 5aca VP1
VP3
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		5 / 11 TYR 3 171
THR 1 167
ASP 3  77
ALA 3  79
ASP 3 175
 None
 1.34A 3id5F-5aca3:
undetectable		 3id5F-5aca3:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD6_0
(GRAMICIDIN D)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 TRP 1  89
ALA 1  50
VAL 1 173
 None
 0.86A 3l8lC-5aca1:
undetectable
3l8lD-5aca1:
undetectable		 3l8lC-5aca1:
10.61
3l8lD-5aca1:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 10 VAL 3 205
PHE 3  80
ALA 3  79
VAL 3 186
VAL 3 161
 None
 1.04A 3me6A-5aca3:
undetectable		 3me6A-5aca3:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_C_CGEC501_1
(CYTOCHROME P450 2B4)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 9 VAL 3 205
PHE 3  80
ALA 3  79
VAL 3 186
VAL 3 161
 None
 1.02A 3me6C-5aca3:
undetectable		 3me6C-5aca3:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 9 VAL 3 205
PHE 3  80
ALA 3  79
VAL 3 186
VAL 3 161
 None
 0.96A 3me6D-5aca3:
undetectable		 3me6D-5aca3:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9C_A_ECLA451_1
(CYTOCHROME P450
164A2)		 5aca VP1
(Foot-and-mouth
disease
virus) 		5 / 10 ALA 1 121
LEU 1 126
LEU 1  53
ALA 1 188
VAL 1  62
 None
 1.22A 3r9cA-5aca1:
undetectable		 3r9cA-5aca1:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 5aca VP1
VP2
(Foot-and-mouth
disease
virus;
Foot-and-mouth
disease
virus) 		4 / 8 TYR 2  36
TYR 2 143
TRP 2 177
ARG 1 129
 None
 1.24A 3wipD-5aca2:
undetectable
3wipE-5aca2:
undetectable		 3wipD-5aca2:
18.29
3wipE-5aca2:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 5aca VP3
(Foot-and-mouth
disease
virus) 		3 / 3 ARG 3 214
PHE 3 215
PRO 3 216
 None
 0.81A 3zoaB-5aca3:
undetectable		 3zoaB-5aca3:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 5aca VP3
(Foot-and-mouth
disease
virus) 		4 / 7 PHE 3  76
THR 3  74
VAL 3 122
VAL 3 188
 None
 0.99A 4cp4A-5aca3:
undetectable		 4cp4A-5aca3:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5aca VP3
(Foot-and-mouth
disease
virus) 		4 / 5 GLN 3 156
THR 3  88
HIS 3  85
LEU 3 104
 None
 1.32A 4lvcA-5aca3:
undetectable		 4lvcA-5aca3:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 5aca VP3
(Foot-and-mouth
disease
virus) 		4 / 5 GLN 3 156
THR 3  88
HIS 3  85
LEU 3 104
 None
 1.30A 4lvcC-5aca3:
undetectable		 4lvcC-5aca3:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 5aca VP2
(Foot-and-mouth
disease
virus) 		4 / 4 VAL 2 109
ALA 2 156
ASN 2 153
GLN 2 146
 None
 1.44A 4zgfA-5aca2:
undetectable		 4zgfA-5aca2:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 12 GLY 3 128
VAL 3  72
GLY 3 184
ASP 3  77
THR 3 182
 None
 0.94A 5hg0A-5aca3:
undetectable		 5hg0A-5aca3:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5aca VP3
(Foot-and-mouth
disease
virus) 		5 / 12 GLY 3 128
VAL 3  72
GLY 3 184
ASP 3  77
THR 3 182
 None
 0.95A 5hg0B-5aca3:
undetectable		 5hg0B-5aca3:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5aca VP1
(Foot-and-mouth
disease
virus) 		3 / 3 THR 1 113
HIS 1  84
ASN 1 111
 None
 0.87A 5n4tA-5aca1:
undetectable		 5n4tA-5aca1:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 5aca VP1
(Foot-and-mouth
disease
virus) 		4 / 8 TYR 1 172
THR 1  47
CYH 1  80
LEU 1  43
 None
 1.43A 6cnjD-5aca1:
undetectable
6cnjE-5aca1:
undetectable		 6cnjD-5aca1:
14.22
6cnjE-5aca1:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 5aca VP3
(Foot-and-mouth
disease
virus) 		4 / 5 GLN 3 156
THR 3  88
HIS 3  85
LEU 3 104
 None
 1.33A 6gbnA-5aca3:
undetectable		 6gbnA-5aca3:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 5aca VP3
(Foot-and-mouth
disease
virus) 		4 / 5 GLN 3 156
THR 3  88
HIS 3  85
LEU 3 104
 None
 1.37A 6gbnD-5aca3:
undetectable		 6gbnD-5aca3:
17.26