SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5adv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 ILE A 180
ILE A 279
ILE A 236
ASP A 242
 None
 0.83A 1uwjA-5advA:
undetectable		 1uwjA-5advA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 4 GLY A  59
SER A 297
VAL A 150
LEU A 137
 None
 1.20A 1yajB-5advA:
undetectable		 1yajB-5advA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 PHE A 245
ALA A 199
ASN A 221
ILE A 209
ILE A 215
 None
 1.07A 2bjfA-5advA:
undetectable		 2bjfA-5advA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 8 ASP A 248
LEU A 253
LEU A 191
HIS A 227
 None
None
None
FE  A1311 ( 3.9A)
 1.11A 2q0iA-5advA:
undetectable		 2q0iA-5advA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 PHE A 245
ALA A 199
ASN A 221
ILE A 209
ILE A 215
 None
 1.00A 2rlcA-5advA:
undetectable		 2rlcA-5advA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_A_TFPA202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 LEU A 126
PHE A 122
LEU A  56
ASP A  57
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.20A 3ko0A-5advA:
undetectable
3ko0B-5advA:
undetectable
3ko0C-5advA:
undetectable
3ko0D-5advA:
undetectable		 3ko0A-5advA:
15.55
3ko0B-5advA:
15.55
3ko0C-5advA:
15.55
3ko0D-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 SER A  40
LEU A 126
PHE A 122
LEU A  56
ASP A  57
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.26A 3ko0G-5advA:
undetectable
3ko0H-5advA:
undetectable
3ko0I-5advA:
undetectable
3ko0J-5advA:
undetectable		 3ko0G-5advA:
15.55
3ko0H-5advA:
15.55
3ko0I-5advA:
15.55
3ko0J-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 11 SER A  40
LEU A  56
ASP A  57
LEU A 126
PHE A 122
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.19A 3ko0A-5advA:
undetectable
3ko0B-5advA:
undetectable
3ko0I-5advA:
undetectable
3ko0J-5advA:
undetectable		 3ko0A-5advA:
15.55
3ko0B-5advA:
15.55
3ko0I-5advA:
15.55
3ko0J-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 LEU A  56
ASP A  57
LEU A 126
PHE A 122
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.22A 3ko0K-5advA:
undetectable
3ko0L-5advA:
undetectable
3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable		 3ko0K-5advA:
15.55
3ko0L-5advA:
15.55
3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 LEU A 126
PHE A 122
LEU A  56
ASP A  57
SER A  40
 None
None
None
None
DMS  A1314 ( 3.7A)
 1.15A 3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable
3ko0O-5advA:
undetectable
3ko0P-5advA:
undetectable		 3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
3ko0O-5advA:
15.55
3ko0P-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_P_TFPP202_1
(PROTEIN S100-A4)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 SER A  40
LEU A  56
ASP A  57
LEU A 126
PHE A 122
 DMS  A1314 ( 3.7A)
None
None
None
None
 1.19A 3ko0M-5advA:
undetectable
3ko0N-5advA:
undetectable
3ko0O-5advA:
undetectable
3ko0P-5advA:
undetectable		 3ko0M-5advA:
15.55
3ko0N-5advA:
15.55
3ko0O-5advA:
15.55
3ko0P-5advA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		4 / 7 ILE A 190
LEU A 263
ALA A 273
ALA A 274
 None
 0.82A 3r9tB-5advA:
undetectable		 3r9tB-5advA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 ILE A  55
VAL A  74
PHE A  64
ILE A  46
ILE A 114
 None
 1.35A 3um5B-5advA:
undetectable		 3um5B-5advA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_A_SAMA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 GLY A 225
ILE A 222
ILE A 189
ARG A 249
SER A 198
 None
None
None
DBS  A1313 ( 3.5A)
None
 1.04A 4iv0A-5advA:
undetectable		 4iv0A-5advA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 GLY A 225
ILE A 222
ILE A 189
ARG A 249
SER A 198
 None
None
None
DBS  A1313 ( 3.5A)
None
 1.08A 4iv0B-5advA:
undetectable		 4iv0B-5advA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 GLY A 225
ILE A 222
ILE A 189
ARG A 249
SER A 198
 None
None
None
DBS  A1313 ( 3.5A)
None
 1.07A 4mwzA-5advA:
undetectable		 4mwzA-5advA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 12 GLY A 225
ILE A 222
ILE A 189
ARG A 249
SER A 198
 None
None
None
DBS  A1313 ( 3.5A)
None
 1.04A 4mwzB-5advA:
undetectable		 4mwzB-5advA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		3 / 3 SER A 297
TYR A  84
ASP A  57
 None
 0.88A 4rp8C-5advA:
undetectable		 4rp8C-5advA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_F_Z80F401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
 None
 1.26A 5lg3F-5advA:
undetectable		 5lg3F-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
 None
 1.24A 5lg3G-5advA:
undetectable		 5lg3G-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 ILE A 244
ILE A 236
VAL A 246
THR A 192
ILE A 262
 None
 1.22A 5lg3H-5advA:
undetectable		 5lg3H-5advA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 5adv ENTEROCHELIN UPTAKE
PERIPLASMIC BINDING
PROTEIN
(Campylobacter
jejuni) 		5 / 10 ILE A 114
LEU A  67
VAL A 150
LEU A 151
GLU A 160
 None
 1.36A 5tixB-5advA:
2.5		 5tixB-5advA:
22.37