SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ady'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEB_A_AMHA90_1
(PLASMINOGEN)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 ASP 6 288
ASP 6 285
ARG 6 257
TYR 6 205
 None
 1.48A 1cebA-5ady6:
undetectable		 1cebA-5ady6:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 12 ILE 6 110
ALA 6 112
LEU 6 232
PHE 6 229
ILE 6 107
 None
 1.11A 1rb2B-5ady6:
undetectable		 1rb2B-5ady6:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 12 ILE 6 110
ALA 6 112
LEU 6 232
PHE 6 229
ILE 6 107
 None
 1.12A 1re7A-5ady6:
undetectable		 1re7A-5ady6:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.79A 1v54P-5ady6:
3.1
1v54W-5ady6:
undetectable		 1v54P-5ady6:
18.29
1v54W-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.79A 2dyrC-5ady6:
3.2
2dyrJ-5ady6:
undetectable		 2dyrC-5ady6:
18.29
2dyrJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.79A 2dyrP-5ady6:
3.1
2dyrW-5ady6:
undetectable		 2dyrP-5ady6:
18.29
2dyrW-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.85A 2eikC-5ady6:
3.1
2eikJ-5ady6:
undetectable		 2eikC-5ady6:
18.29
2eikJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.81A 2eikP-5ady6:
3.1
2eikW-5ady6:
undetectable		 2eikP-5ady6:
18.29
2eikW-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.80A 2eilC-5ady6:
3.1
2eilJ-5ady6:
undetectable		 2eilC-5ady6:
18.29
2eilJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.84A 3ag2C-5ady6:
3.1		 3ag2C-5ady6:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.82A 3ag2P-5ady6:
3.1
3ag2W-5ady6:
undetectable		 3ag2P-5ady6:
18.29
3ag2W-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.75A 3ag4C-5ady6:
3.1
3ag4J-5ady6:
undetectable		 3ag4C-5ady6:
18.29
3ag4J-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.80A 3ag4P-5ady6:
3.1
3ag4W-5ady6:
undetectable		 3ag4P-5ady6:
18.29
3ag4W-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_E_P77E203_1
(PROTEIN S100-A4)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 8 ASP 6 288
SER 6  32
LEU 6  27
ASP 6  26
 None
 0.73A 3m0wE-5ady6:
undetectable
3m0wF-5ady6:
undetectable
3m0wG-5ady6:
undetectable
3m0wH-5ady6:
undetectable		 3m0wE-5ady6:
12.02
3m0wF-5ady6:
12.02
3m0wG-5ady6:
12.02
3m0wH-5ady6:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 LYS 6 336
ARG 6 331
ASP 6 243
 None
 1.01A 3o7wA-5ady6:
undetectable		 3o7wA-5ady6:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 GLN 6 272
THR 6 274
LEU 6 263
 None
 0.76A 3ondA-5ady6:
undetectable		 3ondA-5ady6:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 GLN 6 272
THR 6 274
LEU 6 263
 None
 0.75A 3ondB-5ady6:
undetectable		 3ondB-5ady6:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA504_1
(CYTOCHROME P450 2B4)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 9 LEU 6 263
LEU 6 108
ILE 6 174
GLN 6 123
GLU 6 125
 None
 1.32A 3tmzA-5ady6:
undetectable		 3tmzA-5ady6:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.71A 3x2qC-5ady6:
3.3
3x2qJ-5ady6:
undetectable		 3x2qC-5ady6:
18.29
3x2qJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.73A 3x2qP-5ady6:
3.1
3x2qW-5ady6:
undetectable		 3x2qP-5ady6:
18.29
3x2qW-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 ASP 6  81
ARG 6 103
ASP 6  26
 None
 0.79A 4fzvA-5ady6:
undetectable		 4fzvA-5ady6:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 10 LEU 6 357
LEU 6 353
LEU 6 342
ARG 6 360
THR 6 212
 None
None
None
None
GNP  6 527 (-3.2A)
 1.36A 4mk4A-5ady6:
3.7		 4mk4A-5ady6:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 12 ILE 6 110
ALA 6 112
LEU 6 232
PHE 6 229
ILE 6 107
 None
 1.15A 4ptjA-5ady6:
undetectable		 4ptjA-5ady6:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UUU_A_SAMA1546_0
(CYSTATHIONINE
BETA-SYNTHASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 11 LEU 6  95
ALA 6  63
HIS 6  82
ILE 6 101
ASP 6 102
 None
 1.04A 4uuuA-5ady6:
undetectable
4uuuB-5ady6:
undetectable		 4uuuA-5ady6:
15.20
4uuuB-5ady6:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 12 ILE 6 110
ALA 6 112
LEU 6 232
PHE 6 229
ILE 6 107
 None
 1.07A 4x5jA-5ady6:
undetectable		 4x5jA-5ady6:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 10 GLY 6  38
VAL 6  39
GLU 6  40
VAL 6  34
LEU 6  13
 None
 1.21A 4yb6C-5ady6:
2.8
4yb6F-5ady6:
2.3		 4yb6C-5ady6:
24.54
4yb6F-5ady6:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 10 LEU 6  13
GLY 6  38
VAL 6  39
GLU 6  40
VAL 6  34
 None
 1.20A 4yb6A-5ady6:
2.8
4yb6D-5ady6:
2.7		 4yb6A-5ady6:
24.54
4yb6D-5ady6:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 10 LEU 6  13
GLY 6  38
VAL 6  39
GLU 6  40
VAL 6  34
 None
 1.20A 4yb6D-5ady6:
2.7
4yb6E-5ady6:
2.4		 4yb6D-5ady6:
24.54
4yb6E-5ady6:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 TRP 6 341
ARG 6 339
LEU 6 322
 None
 0.83A 5dbyA-5ady6:
undetectable		 5dbyA-5ady6:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ady GTPASE HFLX
(Escherichia
coli) 		5 / 12 ILE 6 110
ALA 6 112
LEU 6 232
PHE 6 229
ILE 6 107
 None
 1.12A 5e8qA-5ady6:
undetectable		 5e8qA-5ady6:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 5 ILE 6 217
LEU 6 279
HIS 6 282
VAL 6 283
 None
 1.14A 5jmnB-5ady6:
undetectable		 5jmnB-5ady6:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.73A 5z85C-5ady6:
3.1
5z85J-5ady6:
undetectable		 5z85C-5ady6:
18.29
5z85J-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.66A 5zcoC-5ady6:
undetectable
5zcoJ-5ady6:
undetectable		 5zcoC-5ady6:
18.29
5zcoJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.77A 5zcqC-5ady6:
3.1
5zcqJ-5ady6:
undetectable		 5zcqC-5ady6:
18.29
5zcqJ-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ady GTPASE HFLX
(Escherichia
coli) 		4 / 7 LEU 6 402
GLN 6 403
PHE 6 383
LEU 6 379
 None
 0.75A 5zcqP-5ady6:
3.1
5zcqW-5ady6:
undetectable		 5zcqP-5ady6:
18.29
5zcqW-5ady6:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 ASP 6  81
ARG 6 103
ASP 6  26
 None
 0.62A 5zvgA-5ady6:
undetectable		 5zvgA-5ady6:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 5ady GTPASE HFLX
(Escherichia
coli) 		3 / 3 ASP 6  81
ARG 6 103
ASP 6  26
 None
 0.65A 5zvgB-5ady6:
undetectable		 5zvgB-5ady6:
22.65