SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aeb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 118
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1308 (-3.0A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 1.10A 1a4lA-5aebA:
undetectable		 1a4lA-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 121
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1307 (-3.1A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 0.98A 1a4lA-5aebA:
undetectable		 1a4lA-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 118
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1308 (-3.0A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 1.15A 1a4lB-5aebA:
undetectable		 1a4lB-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 118
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1308 (-3.0A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 1.10A 1a4lC-5aebA:
undetectable		 1a4lC-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 121
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1307 (-3.1A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 0.97A 1a4lC-5aebA:
undetectable		 1a4lC-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 HIS A 118
ASP A 153
PHE A 156
HIS A 263
ASP A 120
 ZN  A1308 (-3.0A)
None
None
ZN  A1307 (-3.2A)
ZN  A1307 (-2.5A)
 1.15A 1a4lD-5aebA:
undetectable		 1a4lD-5aebA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 ALA A 155
TYR A 154
TYR A 243
SER A 200
GLN A 116
 None
None
None
None
ZN  A1308 ( 2.5A)
 1.46A 1dy4A-5aebA:
undetectable		 1dy4A-5aebA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 HIS A 192
SER A 202
TYR A 290
PHE A 256
 None
 1.31A 1eqbA-5aebA:
undetectable
1eqbB-5aebA:
undetectable		 1eqbA-5aebA:
21.98
1eqbB-5aebA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 TYR A 290
PHE A 256
HIS A 192
SER A 202
 None
 1.32A 1eqbA-5aebA:
undetectable
1eqbB-5aebA:
undetectable		 1eqbA-5aebA:
21.98
1eqbB-5aebA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 HIS A 192
SER A 202
TYR A 290
PHE A 256
 None
 1.32A 1eqbC-5aebA:
undetectable
1eqbD-5aebA:
undetectable		 1eqbC-5aebA:
21.98
1eqbD-5aebA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 TYR A 290
PHE A 256
HIS A 192
SER A 202
 None
 1.32A 1eqbC-5aebA:
undetectable
1eqbD-5aebA:
undetectable		 1eqbC-5aebA:
21.98
1eqbD-5aebA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 GLU A  30
ASN A  35
GLY A  86
TYR A  54
ALA A 264
 None
 1.21A 1hvyB-5aebA:
undetectable		 1hvyB-5aebA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 7 TYR A 236
GLY A 199
TYR A 154
ASP A 139
 None
 1.08A 2g70B-5aebA:
undetectable		 2g70B-5aebA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 6 TYR A 236
GLY A 199
TYR A 154
ASP A 139
 None
 1.12A 2g72A-5aebA:
undetectable		 2g72A-5aebA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 7 TYR A 236
GLY A 199
TYR A 154
ASP A 139
 None
 1.09A 2g72B-5aebA:
undetectable		 2g72B-5aebA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 5 PRO A  41
PRO A  44
ILE A  55
GLY A  56
 None
 1.15A 2jkjD-5aebA:
undetectable		 2jkjD-5aebA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 5 PRO A  41
PRO A  44
ILE A  55
GLY A  56
 None
 1.16A 2jkjF-5aebA:
undetectable		 2jkjF-5aebA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 4 LYS A 130
ALA A 126
PHE A 165
GLY A 123
 None
 1.32A 2rddA-5aebA:
undetectable		 2rddA-5aebA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 12 ASP A 142
GLY A 199
VAL A 145
SER A 262
HIS A 263
 None
None
None
None
ZN  A1307 (-3.2A)
 1.23A 3d91B-5aebA:
undetectable		 3d91B-5aebA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A1308 (-3.0A)
ZN  A1307 (-2.5A)
ZN  A1308 (-3.0A)
ZN  A1307 (-3.2A)
 0.67A 4exsB-5aebA:
16.8		 4exsB-5aebA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 GLY A  50
ASN A  51
PRO A 281
ILE A  48
 None
 0.99A 4j4vC-5aebA:
undetectable		 4j4vC-5aebA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A1308 (-3.0A)
ZN  A1307 (-2.5A)
ZN  A1308 (-3.0A)
ZN  A1307 (-3.2A)
 0.69A 5a5zA-5aebA:
17.0		 5a5zA-5aebA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 11 ASP A 120
HIS A 121
HIS A 196
VAL A 225
HIS A 263
 ZN  A1307 (-2.5A)
ZN  A1307 (-3.1A)
ZN  A1308 (-3.0A)
None
ZN  A1307 (-3.2A)
 1.02A 5ayaA-5aebA:
33.0		 5ayaA-5aebA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		6 / 11 HIS A 118
ASP A 120
HIS A 121
HIS A 196
THR A 223
HIS A 263
 ZN  A1308 (-3.0A)
ZN  A1307 (-2.5A)
ZN  A1307 (-3.1A)
ZN  A1308 (-3.0A)
None
ZN  A1307 (-3.2A)
 0.31A 5ayaA-5aebA:
33.0		 5ayaA-5aebA:
29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		3 / 3 ALA A 249
ASN A 252
LEU A 254
 None
 0.27A 5i1oC-5aebA:
undetectable		 5i1oC-5aebA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		3 / 3 ALA A 249
ASN A 252
LEU A 254
 None
 0.24A 5i1pA-5aebA:
undetectable		 5i1pA-5aebA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		5 / 11 ASP A 184
VAL A  83
ILE A  81
THR A  75
ILE A 180
 None
 1.16A 5y80A-5aebA:
undetectable		 5y80A-5aebA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 5aeb LRA-12
(uncultured
bacterium
BLR12) 		4 / 8 HIS A 118
ASP A 120
HIS A 196
HIS A 263
 ZN  A1308 (-3.0A)
ZN  A1307 (-2.5A)
ZN  A1308 (-3.0A)
ZN  A1307 (-3.2A)
 0.73A 5zj8A-5aebA:
16.9		 5zj8A-5aebA:
24.57