SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aee'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 HIS A 196
ASP A 198
LEU A 242
LEU A 243
GLY A 460
 None
 1.47A 1d4fA-5aeeA:
3.0		 1d4fA-5aeeA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.31A 1iiuA-5aeeA:
undetectable		 1iiuA-5aeeA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 HIS A 196
LEU A 224
ASP A 198
PHE A 205
 None
 1.25A 1ismB-5aeeA:
undetectable		 1ismB-5aeeA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 ILE A 129
ALA A 123
PHE A 207
PRO A 147
TYR A 193
 None
 0.96A 1jolB-5aeeA:
undetectable		 1jolB-5aeeA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.33A 1kt4A-5aeeA:
undetectable		 1kt4A-5aeeA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 LEU A 592
ALA A 490
ALA A 494
MET A 495
TYR A 130
 None
 1.32A 1kt5A-5aeeA:
undetectable		 1kt5A-5aeeA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 5 ASN A 204
ALA A 216
ASP A 206
GLU A 214
 None
 1.28A 1lqtA-5aeeA:
undetectable
1lqtB-5aeeA:
undetectable		 1lqtA-5aeeA:
21.81
1lqtB-5aeeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 5 ASN A 204
ALA A 216
ASP A 206
GLU A 214
 None
 1.27A 1lquA-5aeeA:
undetectable
1lquB-5aeeA:
undetectable		 1lquA-5aeeA:
21.81
1lquB-5aeeA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA734_1
(ALPHA AMYLASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 ASN A 324
TRP A 323
GLY A 398
TRP A 308
 None
 1.47A 1mxdA-5aeeA:
12.8		 1mxdA-5aeeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 PHE A 207
LEU A 148
GLY A 133
THR A 496
ILE A 129
 None
 1.08A 1phgA-5aeeA:
undetectable		 1phgA-5aeeA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 5 GLY A 506
ILE A 505
VAL A 486
SER A 528
 None
 1.25A 1rs7A-5aeeA:
undetectable		 1rs7A-5aeeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 LEU A 224
ASN A 199
LEU A 217
PHE A 205
 None
 1.45A 1ru9H-5aeeA:
undetectable
1ru9L-5aeeA:
undetectable		 1ru9H-5aeeA:
15.05
1ru9L-5aeeA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 LEU A 224
ASN A 199
LEU A 217
PHE A 205
 None
 1.48A 1rukH-5aeeA:
undetectable
1rukL-5aeeA:
undetectable		 1rukH-5aeeA:
15.05
1rukL-5aeeA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1435_1
(CHITINASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		3 / 3 TRP A  40
GLU A 214
TYR A 212
 None
 0.92A 2a3aA-5aeeA:
4.7		 2a3aA-5aeeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 ALA A 494
TYR A 232
TYR A 601
PHE A 139
 None
 1.10A 2ajvH-5aeeA:
undetectable
2ajvL-5aeeA:
undetectable		 2ajvH-5aeeA:
13.79
2ajvL-5aeeA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 ARG A 301
VAL A 155
GLY A 154
ALA A 167
LEU A 511
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.16A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2001_1
(SERUM ALBUMIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 ARG A 301
VAL A 155
GLY A 154
LEU A 511
SER A 297
 NSQ  A1681 (-3.1A)
CA  A1679 ( 4.7A)
CA  A1679 (-4.6A)
None
None
 1.22A 2bxgA-5aeeA:
undetectable		 2bxgA-5aeeA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H21_B_SAMB802_0
(RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 GLY A 133
LEU A 493
SER A 137
TYR A 138
PHE A 146
 None
 1.41A 2h21B-5aeeA:
undetectable		 2h21B-5aeeA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 LEU A 119
LEU A 217
ALA A 222
ILE A  29
LEU A  30
 None
 1.08A 2jn3A-5aeeA:
2.1		 2jn3A-5aeeA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1050_2
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 VAL A 302
ARG A 455
TRP A 469
THR A 509
 NSQ  A1681 (-3.5A)
NSQ  A1681 (-3.7A)
NSQ  A1681 (-4.8A)
None
 1.09A 2x2iA-5aeeA:
25.7		 2x2iA-5aeeA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_B_2FAB500_1
(ADENOSYLHOMOCYSTEINA
SE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 HIS A 196
ASP A 198
LEU A 242
LEU A 243
GLY A 460
 None
 1.50A 2zj0B-5aeeA:
3.0		 2zj0B-5aeeA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		3 / 3 MET A 403
GLU A 408
ASN A  54
 NSQ  A1681 (-3.6A)
None
None
 0.81A 3a27A-5aeeA:
undetectable		 3a27A-5aeeA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKZ_A_ZMRA469_2
(NEURAMINIDASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 ASP A 405
TRP A 433
ILE A 334
SER A 291
 NSQ  A1681 (-3.3A)
None
None
None
 1.36A 3ckzA-5aeeA:
2.0		 3ckzA-5aeeA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 GLY A 260
GLN A 262
ILE A 505
GLN A 547
 None
 0.89A 3fi0P-5aeeA:
undetectable		 3fi0P-5aeeA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 GLU A 381
LEU A 416
TRP A 429
ASN A 418
 None
 1.43A 3k8mB-5aeeA:
17.2		 3k8mB-5aeeA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_B_NCAB192_0
(NICOTINAMIDASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 11 ASP A 251
LEU A 572
PHE A 565
LEU A 249
ILE A 253
 None
 1.39A 3o94B-5aeeA:
undetectable		 3o94B-5aeeA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 LEU A 568
MET A 587
GLY A 610
ALA A 490
PRO A 532
 None
 1.33A 3tm4A-5aeeA:
undetectable		 3tm4A-5aeeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		3 / 3 GLN A 160
THR A 164
ASN A 158
 None
 0.88A 3v4tE-5aeeA:
undetectable		 3v4tE-5aeeA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V81_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 0.98A 3v81C-5aeeA:
undetectable		 3v81C-5aeeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZTV_A_ADNA1600_1
(NAD NUCLEOTIDASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 9 GLY A 507
ASN A 545
SER A 478
GLY A 482
ASP A 476
 None
 1.25A 3ztvA-5aeeA:
undetectable		 3ztvA-5aeeA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.10A 4a97E-5aeeA:
undetectable		 4a97E-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.09A 4a97D-5aeeA:
undetectable		 4a97D-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.03A 4a97G-5aeeA:
undetectable		 4a97G-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 1.04A 4a97H-5aeeA:
undetectable		 4a97H-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_J_ZPCJ1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 PHE A 530
VAL A 564
ARG A 560
ILE A 678
 None
 0.92A 4a97I-5aeeA:
undetectable		 4a97I-5aeeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 1.13A 4b3qA-5aeeA:
undetectable		 4b3qA-5aeeA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 SER A  73
VAL A  72
ILE A  95
ASN A  94
PHE A  13
 None
 1.39A 4c49B-5aeeA:
undetectable		 4c49B-5aeeA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 7 GLU A 538
ASP A 289
GLN A 262
ILE A 285
 None
 1.07A 4ii8A-5aeeA:
undetectable		 4ii8A-5aeeA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		6 / 12 ALA A 278
ALA A 556
ALA A 559
THR A 562
VAL A 257
LEU A 259
 None
 1.44A 4j6dA-5aeeA:
undetectable		 4j6dA-5aeeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		6 / 12 ALA A 278
ALA A 556
ALA A 559
THR A 562
VAL A 257
LEU A 259
 None
 1.45A 4j6dB-5aeeA:
undetectable		 4j6dB-5aeeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		3 / 3 PRO A 183
ASN A 427
HIS A 426
 None
 0.91A 4ma3H-5aeeA:
undetectable
4ma3L-5aeeA:
1.3		 4ma3H-5aeeA:
16.62
4ma3L-5aeeA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKX_A_198A1002_2
(ANDROGEN RECEPTOR)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 LEU A 148
ASN A 427
LEU A 217
ILE A 424
 None
 1.12A 4okxA-5aeeA:
undetectable		 4okxA-5aeeA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 0.96A 4pwdC-5aeeA:
undetectable		 4pwdC-5aeeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_A_NVPA901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 LEU A 568
VAL A 660
TYR A 662
LEU A 675
 None
 1.10A 4q0bA-5aeeA:
undetectable		 4q0bA-5aeeA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 PHE A  20
ALA A  70
THR A 223
LEU A  39
LEU A  30
 None
 1.48A 4qztC-5aeeA:
undetectable		 4qztC-5aeeA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UMJ_A_BFQA1297_1
(GERANYLTRANSTRANSFER
ASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 SER A  96
LEU A 104
ASP A  99
ARG A 225
 None
 0.99A 4umjA-5aeeA:
undetectable		 4umjA-5aeeA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 SER A 151
PRO A 183
PHE A 181
GLU A 134
 None
 1.13A 5b8iA-5aeeA:
undetectable		 5b8iA-5aeeA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_2
(CALCINEURIN SUBUNIT
B, VARIANT
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 4 LEU A 609
MET A 587
VAL A 586
ASN A 579
 None
 1.08A 5b8iB-5aeeA:
undetectable		 5b8iB-5aeeA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 ILE A 129
ALA A 123
PHE A 207
PRO A 147
TYR A 193
 None
 1.00A 5eajB-5aeeA:
undetectable		 5eajB-5aeeA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 9 ILE A 129
GLY A 131
THR A 496
GLN A 124
LEU A 239
 None
 1.42A 5fhzB-5aeeA:
undetectable		 5fhzB-5aeeA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEF_A_NBVA1005_2
(NEUTRAL
ALPHA-GLUCOSIDASE AB)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 4 ARG A 455
TRP A 469
ASP A 504
ARG A 535
 NSQ  A1681 (-3.7A)
NSQ  A1681 (-4.8A)
NSQ  A1681 ( 4.7A)
None
 0.85A 5iefA-5aeeA:
26.7		 5iefA-5aeeA:
23.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 9 ALA A  91
ILE A 117
GLY A  42
ILE A  65
PRO A  37
 None
 1.28A 5kr2C-5aeeA:
undetectable		 5kr2C-5aeeA:
9.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 8 LEU A 592
PHE A 591
PHE A 139
PRO A 631
 None
 0.98A 5m0oC-5aeeA:
undetectable		 5m0oC-5aeeA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 GLU A 227
ALA A 241
LEU A 242
TYR A 194
 None
 1.16A 5phhA-5aeeA:
undetectable		 5phhA-5aeeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 LEU A 493
GLY A 131
PHE A 182
GLN A 246
LEU A 243
 None
 1.27A 5uc3B-5aeeA:
undetectable		 5uc3B-5aeeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_0
(REGULATORY PROTEIN
TETR)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 MET A 561
ALA A 529
LEU A 675
VAL A 615
ASP A 612
 None
 1.50A 5vlmD-5aeeA:
0.4		 5vlmD-5aeeA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		4 / 6 ALA A 287
GLN A 262
TRP A 286
ASP A 504
 None
None
None
NSQ  A1681 ( 4.7A)
 1.41A 5y9aA-5aeeA:
undetectable		 5y9aA-5aeeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_A_ADNA505_1
(-)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 HIS A 196
ASP A 198
LEU A 242
LEU A 243
GLY A 460
 None
 1.49A 6f3nA-5aeeA:
3.0		 6f3nA-5aeeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 HIS A 196
ASP A 198
LEU A 242
LEU A 243
GLY A 460
 None
 1.47A 6f3nC-5aeeA:
3.0		 6f3nC-5aeeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_D_ADND506_1
(-)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 12 HIS A 196
ASP A 198
LEU A 242
LEU A 243
GLY A 460
 None
 1.50A 6f3nD-5aeeA:
3.1		 6f3nD-5aeeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5aee ALPHA-GLUCOSIDASE
YIHQ
(Escherichia
coli) 		5 / 10 ALA A 616
HIS A 637
LEU A 628
LEU A 630
VAL A 649
 None
 1.37A 6g2pB-5aeeA:
undetectable		 6g2pB-5aeeA:
20.81