SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aek'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5aek SENTRIN-SPECIFIC
PROTEASE 2
(Homo
sapiens) 		5 / 12 MET A 420
HIS A 436
ASN A 417
PRO A 472
LEU A 481
 None
 1.31A 3tm4B-5aekA:
undetectable		 3tm4B-5aekA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 5aek SENTRIN-SPECIFIC
PROTEASE 2
(Homo
sapiens) 		3 / 3 SER A 390
PHE A 393
LYS A 394
 None
 0.96A 3u88A-5aekA:
undetectable		 3u88A-5aekA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 5aek SENTRIN-SPECIFIC
PROTEASE 2
(Homo
sapiens) 		6 / 12 LEU A 368
LEU A 422
MET A 372
GLU A 375
ILE A 376
ALA A 379
 None
 1.04A 4ltwA-5aekA:
undetectable		 4ltwA-5aekA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5aek SENTRIN-SPECIFIC
PROTEASE 2
(Homo
sapiens) 		3 / 3 GLY A 400
ASP A 401
ASN A 417
 None
 0.62A 5jglA-5aekA:
undetectable		 5jglA-5aekA:
20.49