SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aew'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CEA_A_ACAA90_1
(PLASMINOGEN)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		4 / 8 ASP A 361
TYR A 370
TYR A 295
THR A 201
 None
 1.43A 1ceaA-5aewA:
undetectable
1ceaB-5aewA:
undetectable		 1ceaA-5aewA:
9.71
1ceaB-5aewA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 12 ILE A 208
PHE A 355
GLY A 210
HIS A 343
LEU A  60
 None
 1.41A 1fm6X-5aewA:
undetectable		 1fm6X-5aewA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 TRP A 454
HIS A 444
MET A 448
 None
 1.07A 1l5qB-5aewA:
undetectable		 1l5qB-5aewA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 345
VAL A 352
TRP A 353
 None
 1.24A 1qw6A-5aewA:
undetectable		 1qw6A-5aewA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 345
VAL A 352
TRP A 353
 None
 1.19A 1qwcA-5aewA:
undetectable		 1qwcA-5aewA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 345
VAL A 352
TRP A 353
 None
 1.20A 1zviA-5aewA:
undetectable		 1zviA-5aewA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_D_CHDD702_0
(FERROCHELATASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 376
GLY A 289
PRO A 290
 None
 0.50A 2hreD-5aewA:
undetectable		 2hreD-5aewA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 12 ASN A 337
ILE A 216
ILE A 350
TRP A 214
PHE A 227
 None
 1.47A 2qmjA-5aewA:
undetectable		 2qmjA-5aewA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		4 / 4 ARG A 439
GLY A 440
GLU A 436
SER A 450
 None
 1.35A 2xctS-5aewA:
undetectable
2xctU-5aewA:
undetectable		 2xctS-5aewA:
20.92
2xctU-5aewA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXT_A_SAMA397_0
(PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 12 LEU A  35
ILE A  24
GLU A 435
ALA A 411
ASP A  36
 None
 1.19A 3axtA-5aewA:
undetectable		 3axtA-5aewA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ASP A 388
PHE A 378
SER A 331
 FE2  A 461 (-2.2A)
None
None
 0.73A 3i5uB-5aewA:
undetectable		 3i5uB-5aewA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		4 / 8 ASP A  36
TYR A  40
LEU A  45
LEU A  27
 None
 1.00A 3lm8B-5aewA:
undetectable
3lm8D-5aewA:
undetectable		 3lm8B-5aewA:
18.95
3lm8D-5aewA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 PHE A 327
VAL A  53
GLU A  49
 None
 0.82A 4fvqA-5aewA:
undetectable		 4fvqA-5aewA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 12 ALA A 223
VAL A 352
GLY A 389
ILE A 350
ILE A 395
 None
 0.91A 4q5mA-5aewA:
undetectable		 4q5mA-5aewA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7I_A_STIA1001_2
(MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		4 / 5 LEU A  60
VAL A  95
VAL A  67
ARG A 109
 None
 1.09A 4r7iA-5aewA:
undetectable		 4r7iA-5aewA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 ARG A 345
VAL A 352
TRP A 353
 None
 1.21A 5fvoA-5aewA:
undetectable		 5fvoA-5aewA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_A_CP6A704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 10 VAL A  86
ALA A 130
ASP A 128
PHE A 118
VAL A  84
 None
 1.34A 6aogA-5aewA:
undetectable		 6aogA-5aewA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AOG_B_CP6B704_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		5 / 10 VAL A  86
ALA A 130
ASP A 128
PHE A 118
VAL A  84
 None
 1.33A 6aogB-5aewA:
undetectable		 6aogB-5aewA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5aew BIPHENYL DIOXYGENASE
SUBUNIT ALPHA
(Paraburkholderia
xenovorans) 		3 / 3 THR A 238
GLU A 225
ASN A 391
 None
 0.79A 6nj9K-5aewA:
undetectable		 6nj9K-5aewA:
22.02