SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aex'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  56
SER A  54
LEU A  51
THR A 289
GLU A 441
 None
 1.25A 1kw0A-5aexA:
undetectable		 1kw0A-5aexA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
SER A  54
LEU A  51
THR A 289
GLU A 441
 None
 1.22A 1mmtA-5aexA:
undetectable		 1mmtA-5aexA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.15A 1p6kA-5aexA:
undetectable		 1p6kA-5aexA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.14A 1p6kB-5aexA:
undetectable		 1p6kB-5aexA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_A_DIFA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.12A 1pxxA-5aexA:
undetectable		 1pxxA-5aexA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.14A 1pxxB-5aexA:
0.8		 1pxxB-5aexA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.13A 1pxxD-5aexA:
undetectable		 1pxxD-5aexA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_A_SAMA500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 186
TRP A 173
PHE A 309
SER A 249
 None
 1.20A 1rqpB-5aexA:
undetectable		 1rqpB-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 186
TRP A 173
PHE A 309
SER A 249
 None
 1.19A 1rqpA-5aexA:
undetectable		 1rqpA-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 1rs6A-5aexA:
undetectable		 1rs6A-5aexA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 1rs6B-5aexA:
undetectable		 1rs6B-5aexA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.16A 1rs7B-5aexA:
undetectable		 1rs7B-5aexA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 395
GLY A 391
ILE A 397
ALA A 399
SER A 184
 None
 1.13A 1ve3B-5aexA:
undetectable		 1ve3B-5aexA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 351
GLY A 349
LEU A 202
GLY A 201
TYR A  53
 None
 1.08A 1y4lA-5aexA:
undetectable		 1y4lA-5aexA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y4L_B_SVRB301_1
(PHOSPHOLIPASE A2
HOMOLOG 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 352
GLY A 349
LEU A 202
GLY A 201
TYR A  53
 None
 0.93A 1y4lA-5aexA:
undetectable		 1y4lA-5aexA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.13A 1zzqA-5aexA:
undetectable		 1zzqA-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.10A 1zzqB-5aexA:
undetectable		 1zzqB-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_B_RBFB301_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 303
LEU A 300
ALA A 307
GLY A 247
TRP A 242
 None
 1.25A 2a58A-5aexA:
undetectable
2a58B-5aexA:
undetectable		 2a58A-5aexA:
17.34
2a58B-5aexA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_C_RBFC302_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 303
LEU A 300
ALA A 307
GLY A 247
TRP A 242
 None
 1.24A 2a58B-5aexA:
undetectable
2a58C-5aexA:
undetectable		 2a58B-5aexA:
17.34
2a58C-5aexA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A58_E_RBFE304_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 303
LEU A 300
ALA A 307
GLY A 247
TRP A 242
 None
 1.25A 2a58D-5aexA:
undetectable
2a58E-5aexA:
undetectable		 2a58D-5aexA:
17.34
2a58E-5aexA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 133
TYR A 165
TYR A 128
PHE A  89
 None
 1.19A 2ajvH-5aexA:
undetectable
2ajvL-5aexA:
undetectable		 2ajvH-5aexA:
19.09
2ajvL-5aexA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 259
ALA A 306
GLY A 308
VAL A 367
ASN A 246
 None
 1.13A 2okcA-5aexA:
undetectable		 2okcA-5aexA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 259
ALA A 306
GLY A 308
VAL A 367
ASN A 246
 None
 1.14A 2okcB-5aexA:
undetectable		 2okcB-5aexA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX6_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 6 TRP A 173
GLY A 251
GLY A 308
PHE A 132
 None
 0.99A 2qx6A-5aexA:
undetectable
2qx6B-5aexA:
undetectable		 2qx6A-5aexA:
18.86
2qx6B-5aexA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
SER A 119
TYR A 374
VAL A 117
 None
 1.18A 2uz2A-5aexA:
undetectable		 2uz2A-5aexA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 186
TRP A 173
PHE A 309
SER A 249
 None
 1.15A 2v7uA-5aexA:
undetectable		 2v7uA-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_B_SAMB1299_1
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 ASP A 186
TRP A 173
PHE A 309
SER A 249
 None
 1.16A 2v7uB-5aexA:
undetectable		 2v7uB-5aexA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_G_RBFG200_1
(DODECIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 226
TYR A 444
THR A 448
GLN A 438
 None
 1.44A 2vxaF-5aexA:
undetectable
2vxaG-5aexA:
undetectable
2vxaI-5aexA:
undetectable		 2vxaF-5aexA:
9.15
2vxaG-5aexA:
9.15
2vxaI-5aexA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_B_SAMB1267_0
(NON-STRUCTURAL
PROTEIN 5)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 351
GLY A 295
GLY A 323
LEU A 273
ILE A 296
 None
 0.97A 2wa2B-5aexA:
undetectable		 2wa2B-5aexA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.30A 2yldA-5aexA:
undetectable		 2yldA-5aexA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.27A 2ylgA-5aexA:
undetectable		 2ylgA-5aexA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 157
TRP A 160
GLY A 200
 None
 0.79A 3l35A-5aexA:
undetectable
3l35H-5aexA:
undetectable		 3l35A-5aexA:
5.52
3l35H-5aexA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 157
TRP A 160
GLY A 200
 None
 0.77A 3l35B-5aexA:
undetectable
3l35K-5aexA:
undetectable		 3l35B-5aexA:
5.52
3l35K-5aexA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 173
ALA A 175
VAL A 172
 None
 0.96A 3l8lA-5aexA:
undetectable
3l8lB-5aexA:
undetectable		 3l8lA-5aexA:
6.37
3l8lB-5aexA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 6 ILE A 168
ALA A 169
ALA A 133
THR A 136
 None
 0.80A 3mdrB-5aexA:
undetectable		 3mdrB-5aexA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 137
ALA A 138
ILE A  77
VAL A  42
ALA A 133
 None
 0.83A 3n3iA-5aexA:
undetectable		 3n3iA-5aexA:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.20A 3n62A-5aexA:
undetectable		 3n62A-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 190
TRP A 173
VAL A 172
 None
 0.76A 3n62B-5aexA:
undetectable		 3n62B-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.17A 3n62B-5aexA:
undetectable		 3n62B-5aexA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 190
TRP A 173
VAL A 172
 None
 0.73A 3n66B-5aexA:
undetectable		 3n66B-5aexA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.10A 3n66B-5aexA:
undetectable		 3n66B-5aexA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 8 ALA A  88
PHE A  89
PHE A 132
ALA A 133
THR A 136
 None
 1.26A 3t3sD-5aexA:
undetectable		 3t3sD-5aexA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_D_9PLD1_1
(CYTOCHROME P450 2A13)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 8 PHE A 125
PHE A  89
PHE A 132
ALA A 133
THR A 136
 None
 1.30A 3t3sD-5aexA:
undetectable		 3t3sD-5aexA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  88
PHE A 132
ALA A 133
THR A 136
 None
 1.01A 3t3sE-5aexA:
undetectable		 3t3sE-5aexA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.30A 3zwiA-5aexA:
undetectable		 3zwiA-5aexA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 120
GLY A 112
GLY A  16
LEU A 124
ASP A 122
 None
 1.07A 4blvA-5aexA:
undetectable		 4blvA-5aexA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CIP_A_ASCA130_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.31A 4cipA-5aexA:
0.0		 4cipA-5aexA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 143
CYH A 344
SER A 197
HIS A 194
LEU A 238
 None
 1.50A 4emaA-5aexA:
0.0		 4emaA-5aexA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 351
CYH A 326
THR A 322
GLY A 295
 None
 0.72A 4fo4B-5aexA:
undetectable		 4fo4B-5aexA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_F_CAMF502_0
(CAMPHOR
5-MONOOXYGENASE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 4 TYR A  53
THR A 235
VAL A 290
ILE A 347
 None
 1.45A 4jx1F-5aexA:
undetectable		 4jx1F-5aexA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 4kcnB-5aexA:
undetectable		 4kcnB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 191
PRO A 305
VAL A 301
HIS A 348
 None
 1.11A 4qknA-5aexA:
2.0		 4qknA-5aexA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 299
GLY A 323
ILE A 296
ILE A 318
ALA A 267
 None
 1.01A 4qtuB-5aexA:
undetectable		 4qtuB-5aexA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 299
GLY A 323
ILE A 296
ILE A 318
ALA A 267
 None
 1.02A 4qtuD-5aexA:
undetectable		 4qtuD-5aexA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 THR A 322
ALA A 307
GLY A 351
GLY A 352
ASP A 186
 None
 1.08A 4qvwK-5aexA:
undetectable
4qvwL-5aexA:
undetectable		 4qvwK-5aexA:
20.09
4qvwL-5aexA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 THR A 322
ALA A 307
GLY A 351
GLY A 352
ASP A 186
 None
 1.09A 4qvwY-5aexA:
undetectable
4qvwZ-5aexA:
undetectable		 4qvwY-5aexA:
20.09
4qvwZ-5aexA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 120
TYR A 128
GLY A 251
ALA A 250
SER A 249
 None
 1.12A 4rrxA-5aexA:
undetectable		 4rrxA-5aexA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 120
GLY A 251
ALA A 250
SER A 249
 None
 0.90A 5f1aB-5aexA:
undetectable		 5f1aB-5aexA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 GLY A  16
PRO A 121
THR A  14
THR A  21
 None
 1.06A 5h5fA-5aexA:
undetectable		 5h5fA-5aexA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.30A 5jliA-5aexA:
undetectable		 5jliA-5aexA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSL_A_ASCA202_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 4 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.29A 5jslA-5aexA:
0.0		 5jslA-5aexA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 5 ALA A 138
GLY A 143
CYH A 344
HIS A 348
 None
 1.28A 5jt4A-5aexA:
undetectable		 5jt4A-5aexA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH614_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  49
VAL A 193
VAL A 135
SER A 197
 None
 1.00A 5jwaH-5aexA:
undetectable		 5jwaH-5aexA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 308
ILE A 312
LEU A 266
THR A 264
ALA A 267
 None
 1.03A 5vm8B-5aexA:
undetectable		 5vm8B-5aexA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_A_MTLA805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.10A 5vunA-5aexA:
undetectable		 5vunA-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.13A 5vunB-5aexA:
undetectable		 5vunB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.12A 5vuoB-5aexA:
undetectable		 5vuoB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		4 / 8 SER A 116
ASN A 174
PHE A  89
ASP A 122
 None
 1.11A 6auuB-5aexA:
undetectable		 6auuB-5aexA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 107
ILE A 123
LEU A 124
ILE A  77
ALA A  38
 None
 1.46A 6b5vA-5aexA:
undetectable
6b5vC-5aexA:
undetectable		 6b5vA-5aexA:
9.56
6b5vC-5aexA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 7 PHE A 107
ILE A 123
LEU A 124
ILE A  77
ALA A  38
 None
 1.46A 6b5vC-5aexA:
undetectable
6b5vD-5aexA:
undetectable		 6b5vC-5aexA:
9.56
6b5vD-5aexA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 7 ALA A  38
PHE A 107
ILE A 123
LEU A 124
ILE A  77
 None
 1.46A 6b5vB-5aexA:
undetectable
6b5vD-5aexA:
undetectable		 6b5vB-5aexA:
9.56
6b5vD-5aexA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBP_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 10 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.05A 6ebpD-5aexA:
2.6		 6ebpD-5aexA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_A_DAHA123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.05A 6ebzA-5aexA:
2.6		 6ebzA-5aexA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_B_DAHB123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.04A 6ebzB-5aexA:
undetectable		 6ebzB-5aexA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_C_DAHC123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.03A 6ebzC-5aexA:
2.6		 6ebzC-5aexA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EBZ_D_DAHD123_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.04A 6ebzD-5aexA:
2.6		 6ebzD-5aexA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_A_DAHA126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.05A 6gp2A-5aexA:
undetectable		 6gp2A-5aexA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GP2_B_DAHB126_0
(RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
BETA CHAIN)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
 None
 1.01A 6gp2B-5aexA:
undetectable		 6gp2B-5aexA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 5aex AMMONIUM TRANSPORTER
MEP2
(Saccharomyces
cerevisiae) 		5 / 11 MET A 131
GLY A 130
GLN A  79
THR A 162
PHE A  81
 None
 1.39A 6nknA-5aexA:
0.0
6nknB-5aexA:
undetectable
6nknT-5aexA:
undetectable		 6nknA-5aexA:
24.23
6nknB-5aexA:
17.67
6nknT-5aexA:
11.14