SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aey'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 ASP A   7
LYS A 123
ARG A 127
 None
 1.18A 1ra8A-5aeyA:
undetectable		 1ra8A-5aeyA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_B_SAMB601_1
(CATECHOL-O-METHYLTRA
NSFERASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 SER A 195
GLU A 148
ASP A   7
 None
ANP  A 500 (-3.2A)
None
 0.91A 2avdB-5aeyA:
undetectable		 2avdB-5aeyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 LYS A  13
ASP A 177
ASP A 194
 ANP  A 500 (-2.3A)
None
None
 1.09A 2br4A-5aeyA:
undetectable		 2br4A-5aeyA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD37_0
(GCN4 LEUCINE ZIPPER)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 LYS A 291
ARG A 300
VAL A 276
 None
 1.04A 2r2vC-5aeyA:
undetectable
2r2vD-5aeyA:
undetectable		 2r2vC-5aeyA:
9.33
2r2vD-5aeyA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAT_A_CLMA301_0
(XENOBIOTIC
ACETYLTRANSFERASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 GLY A 272
TYR A 273
SER A 271
 None
 0.72A 2xatA-5aeyA:
undetectable		 2xatA-5aeyA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		4 / 6 GLY A 314
GLU A 155
GLY A 153
ASN A 313
 None
 1.04A 3e9rC-5aeyA:
undetectable		 3e9rC-5aeyA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		3 / 3 GLY A  90
SER A  89
TRP A  16
 None
 0.65A 4e7cD-5aeyA:
undetectable		 4e7cD-5aeyA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 5aey PLASMID SEGREGATION
PROTEIN PARM
(Escherichia
coli) 		4 / 8 GLN A 308
ILE A 227
GLY A 281
ASN A  11
 ANP  A 500 (-2.6A)
ANP  A 500 (-4.0A)
ANP  A 500 (-3.6A)
ANP  A 500 (-4.3A)
 1.04A 5hwaA-5aeyA:
undetectable		 5hwaA-5aeyA:
19.82