SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5af3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.99A 1c8lA-5af3A:
undetectable		 1c8lA-5af3A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CQP_B_803B311_1
(ANTIGEN CD11A (P180))		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 159
VAL A 155
LEU A  96
LEU A  99
 None
 0.83A 1cqpA-5af3A:
undetectable
1cqpB-5af3A:
undetectable		 1cqpA-5af3A:
20.24
1cqpB-5af3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 109
ILE A 162
LEU A 175
PRO A 176
ILE A  73
 None
 1.00A 1dg5A-5af3A:
undetectable		 1dg5A-5af3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.94A 1gfzA-5af3A:
undetectable		 1gfzA-5af3A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.93A 1l5qA-5af3A:
undetectable		 1l5qA-5af3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.94A 1l5qB-5af3A:
undetectable		 1l5qB-5af3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.93A 1l7xA-5af3A:
undetectable		 1l7xA-5af3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.91A 1l7xB-5af3A:
undetectable		 1l7xB-5af3A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 LEU A 121
PHE A 124
ALA A 125
LEU A 141
 None
 0.99A 1ukbA-5af3A:
undetectable		 1ukbA-5af3A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 10 ALA A  74
ALA A  76
LEU A  32
LEU A  25
ALA A  21
 None
 1.07A 2bxgB-5af3A:
undetectable		 2bxgB-5af3A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  96
ILE A  55
ILE A  54
VAL A  87
VAL A 137
 None
 0.87A 2ygoA-5af3A:
undetectable		 2ygoA-5af3A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 5 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.95A 3bcrA-5af3A:
undetectable		 3bcrA-5af3A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.96A 3dd1A-5af3A:
undetectable		 3dd1A-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.92A 3dd1B-5af3A:
undetectable		 3dd1B-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.95A 3ddsA-5af3A:
undetectable		 3ddsA-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.94A 3ddsB-5af3A:
undetectable		 3ddsB-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.95A 3ddwA-5af3A:
undetectable		 3ddwA-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 182
ALA A 181
GLY A 179
TYR A 178
 None
 0.93A 3ddwB-5af3A:
undetectable		 3ddwB-5af3A:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 143
VAL A 155
LEU A 159
GLY A 117
ALA A 118
 None
 0.99A 3n8wA-5af3A:
undetectable		 3n8wA-5af3A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 143
VAL A 155
LEU A 159
GLY A 117
ALA A 118
 None
 0.96A 3rr3C-5af3A:
undetectable		 3rr3C-5af3A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 VAL A 143
VAL A 155
LEU A 159
GLY A 117
ALA A 118
 None
 0.96A 3rr3D-5af3A:
undetectable		 3rr3D-5af3A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 173
HIS A 106
VAL A 103
PHE A 164
 None
 1.10A 4a97H-5af3A:
undetectable		 4a97H-5af3A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 109
ILE A 162
LEU A 175
PRO A 176
ILE A  73
 None
 1.07A 4m2xC-5af3A:
undetectable		 4m2xC-5af3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 109
ILE A 162
LEU A 175
PRO A 176
ILE A  73
 None
 0.96A 4m2xG-5af3A:
undetectable		 4m2xG-5af3A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 GLU A  20
LEU A  25
GLY A  72
ALA A  74
ILE A 173
 None
 1.22A 4xe5A-5af3A:
undetectable		 4xe5A-5af3A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 206
VAL A 225
GLY A 224
PHE A 196
 None
 1.04A 5d4nA-5af3A:
undetectable
5d4nC-5af3A:
undetectable		 5d4nA-5af3A:
21.43
5d4nC-5af3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 154
LEU A 141
GLY A 140
ALA A 118
VAL A 150
 None
 0.96A 5x66F-5af3A:
undetectable		 5x66F-5af3A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  18
GLY A  72
ALA A  21
PHE A  11
THR A  56
 None
 1.31A 5x6yA-5af3A:
undetectable		 5x6yA-5af3A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC902_0
(MRNA CAPPING ENZYME
P5)		 5af3 VAPBC49
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  18
GLY A  72
ALA A  21
PHE A  11
THR A  56
 None
 1.28A 5x6yC-5af3A:
undetectable		 5x6yC-5af3A:
15.43