SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5af7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 11 HIS A 355
GLU A  73
ARG A 300
LEU A 255
ALA A 258
 None
 1.24A 1mjlA-5af7A:
undetectable
1mjlB-5af7A:
undetectable		 1mjlA-5af7A:
13.23
1mjlB-5af7A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		4 / 6 ASP A  67
GLY A  51
ILE A  94
ILE A  72
 None
 0.94A 1n49D-5af7A:
undetectable		 1n49D-5af7A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 11 ALA A 330
GLY A 249
GLY A 256
ILE A 257
VAL A  69
 None
 1.14A 1pg2A-5af7A:
2.4		 1pg2A-5af7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_2
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		4 / 4 MET A  50
PRO A  37
ASP A 117
ARG A  84
 None
None
None
FAD  A 410 (-3.7A)
 1.40A 2qm9B-5af7A:
undetectable		 2qm9B-5af7A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_A_LDPA501_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		4 / 7 GLY A  92
PHE A 167
ILE A 123
PHE A 236
 None
None
FAD  A 410 (-3.6A)
None
 0.97A 2qmzA-5af7A:
undetectable
2qmzB-5af7A:
undetectable		 2qmzA-5af7A:
21.77
2qmzB-5af7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 12 MET A  75
VAL A  41
VAL A  22
VAL A 160
ILE A 208
 None
 0.97A 3dl9A-5af7A:
undetectable		 3dl9A-5af7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		4 / 7 LEU A 255
GLN A 259
PHE A 262
VAL A 266
 None
 1.12A 3jwqC-5af7A:
undetectable		 3jwqC-5af7A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		4 / 9 TYR A 243
LYS A 152
PHE A 236
ILE A 226
 None
 1.23A 4jvlA-5af7A:
undetectable		 4jvlA-5af7A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 8 LEU A 372
PRO A 314
SER A 309
VAL A  87
GLY A 249
 None
 1.22A 4klrB-5af7A:
undetectable		 4klrB-5af7A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		6 / 12 TYR A 243
ASN A 244
ALA A  96
GLY A  95
GLY A  92
GLY A 101
 None
 1.33A 4obwB-5af7A:
undetectable		 4obwB-5af7A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 12 VAL A  87
ASP A  88
LEU A 372
ALA A 250
THR A 368
 None
GOL  A 510 ( 4.6A)
None
None
FAD  A 410 (-2.8A)
 1.13A 5nd3B-5af7A:
undetectable		 5nd3B-5af7A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 10 VAL A 248
GLY A 249
ILE A  70
LEU A  66
ALA A 307
 None
 0.93A 5vm8B-5af7A:
undetectable		 5vm8B-5af7A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 5af7 ACYL-COA
DEHYDROGENASE
(Advenella
mimigardefordens
is) 		5 / 12 ALA A 326
ALA A 322
GLY A  83
ALA A  76
VAL A  69
 None
 0.93A 5w4zB-5af7A:
undetectable		 5w4zB-5af7A:
13.10