SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5afd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 12 ASN A 168
GLY A 170
ILE A  51
GLY A 106
ILE A 105
 None
None
EDO  A1302 ( 4.7A)
None
EDO  A1302 ( 4.3A)
 0.98A 1q8jB-5afdA:
6.0		 1q8jB-5afdA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		4 / 8 TRP A  65
ALA A  62
LEU A  97
ASP A  27
 None
 1.15A 2bxkA-5afdA:
undetectable		 2bxkA-5afdA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_A_SAMA300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		3 / 3 SER A 221
HIS A 300
ASP A 265
 None
 0.75A 2oxtA-5afdA:
undetectable		 2oxtA-5afdA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 10 GLU A  57
ARG A 272
GLY A  48
LEU A  33
ILE A  26
 None
GOL  A1301 ( 4.8A)
None
None
None
 1.43A 3adsA-5afdA:
undetectable		 3adsA-5afdA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 12 GLY A 164
SER A 163
LEU A 152
PHE A 151
CYH A 122
 None
 1.09A 3e23A-5afdA:
undetectable		 3e23A-5afdA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KL3_A_DHIA403_0
(GLUCURONOXYLANASE
XYNC)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		4 / 4 GLY A 133
TYR A 135
GLY A 164
ASP A 187
 None
 1.17A 3kl3A-5afdA:
9.3		 3kl3A-5afdA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A2000_1
(P38A)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 12 ASP A  86
ILE A  84
ILE A  99
ILE A 125
ALA A  81
 None
 1.17A 3ohtA-5afdA:
undetectable
3ohtB-5afdA:
undetectable		 3ohtA-5afdA:
19.49
3ohtB-5afdA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 10 GLY A 191
ASP A 193
GLU A 194
GLY A 209
SER A 210
 None
EDO  A1304 (-3.7A)
EDO  A1304 (-3.0A)
None
EDO  A1304 ( 3.9A)
 0.32A 4bwlC-5afdA:
38.2		 4bwlC-5afdA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		5 / 9 LEU A 165
GLU A 174
SER A 169
VAL A 202
LEU A 172
 None
 1.49A 4wnvA-5afdA:
undetectable		 4wnvA-5afdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_W_MFXW2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		4 / 5 ARG A 272
SER A  54
ASP A  16
GLU A  24
 GOL  A1301 ( 4.8A)
None
None
None
 1.07A 5cdqR-5afdA:
0.3
5cdqT-5afdA:
0.0
5cdqU-5afdA:
0.0		 5cdqR-5afdA:
20.54
5cdqT-5afdA:
20.54
5cdqU-5afdA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5afd N-ACETYLNEURAMINATE
LYASE
(Aliivibrio
salmonicida) 		3 / 3 ASN A  22
VAL A 254
HIS A  12
 None
 0.53A 6a5yD-5afdA:
undetectable		 6a5yD-5afdA:
14.86