SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5afe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_1
(PROTEIN (METHIONINE
REPRESSOR))
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
None
1.41A 1mj2B-5afeA:
undetectable
1mj2B-5afeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_1
(PROTEIN (METHIONINE
REPRESSOR))
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
None
1.36A 1mj2D-5afeA:
undetectable
1mj2D-5afeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_0
(METHIONINE REPRESSOR)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
None
1.42A 1mjoA-5afeA:
undetectable
1mjoA-5afeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_1
(METHIONINE REPRESSOR)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
4 / 4 HIS A 596
ALA A 597
PHE A 599
GLY A 696
None
1.39A 1mjoD-5afeA:
undetectable
1mjoD-5afeA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 11 LEU A 641
ILE A 686
PHE A 628
ALA A 652
LEU A 683
None
1.13A 2q72A-5afeA:
undetectable
2q72A-5afeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA801_1
(TRANSPORTER)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 12 LEU A 641
ILE A 686
PHE A 628
ALA A 652
LEU A 683
None
1.12A 2qb4A-5afeA:
undetectable
2qb4A-5afeA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_A_TMQA611_1
(DHFR-TS)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 11 ALA A 652
ILE A 654
ILE A 630
LEU A 622
ILE A 686
None
1.08A 3clbA-5afeA:
undetectable
3clbA-5afeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_C_TMQC613_1
(DHFR-TS)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 12 ALA A 652
ILE A 654
ILE A 630
LEU A 622
ILE A 686
None
1.02A 3clbC-5afeA:
undetectable
3clbC-5afeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_A_TMQA611_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 10 ALA A 652
ILE A 654
ILE A 630
LEU A 622
ILE A 686
None
1.09A 3hbbA-5afeA:
undetectable
3hbbA-5afeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 11 ALA A 652
ILE A 654
ILE A 630
LEU A 622
ILE A 686
None
1.00A 3hbbC-5afeA:
undetectable
3hbbC-5afeA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 12 PRO A 692
PHE A 599
GLY A 696
THR A 698
GLU A 694
None
1.33A 5hfjA-5afeA:
undetectable
5hfjA-5afeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
5 / 12 PRO A 692
PHE A 599
GLY A 696
THR A 698
GLU A 694
None
1.29A 5hfjG-5afeA:
undetectable
5hfjG-5afeA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)
5afe ENDOGLUCANASE CEL5A
([Eubacterium]
cellulosolvens)
4 / 5 PHE A 643
LEU A 590
GLY A 704
ILE A 671
None
0.86A 5ik1A-5afeA:
undetectable
5ik1A-5afeA:
14.64