SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aff'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC8_0
(ACTINOMYCIN D)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 THR A 280
THR A 282
PRO A 279
 None
 0.84A 1dscC-5affA:
undetectable		 1dscC-5affA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_1
(ALPHA-AMYLASE)		 5aff RIBOSOMAL PROTEIN L5
SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 HIS A 514
ALA A 567
GLY A 564
GLU A 460
HIS B   4
 None
 1.24A 1kxhA-5affA:
undetectable		 1kxhA-5affA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 11 LEU A 121
GLU A 173
ILE A 174
LEU A 100
LEU A 163
 None
 1.22A 1mrqA-5affA:
undetectable		 1mrqA-5affA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_W_DVAW8_0
(7-AMINO-ACTINOMYCIN
D)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 THR A 280
THR A 282
PRO A 279
 None
 0.85A 1unjW-5affA:
undetectable		 1unjW-5affA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_E_DVAE8_0
(7-AMINOACTINOMYCIN D)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 THR A 280
THR A 282
PRO A 279
 None
 0.85A 1unmE-5affA:
undetectable		 1unmE-5affA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNM_F_DVAF8_0
(7-AMINOACTINOMYCIN D)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 THR A 280
THR A 282
PRO A 279
 None
 0.86A 1unmF-5affA:
undetectable		 1unmF-5affA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 7 ASP A 155
THR A 157
PHE A 142
GLN A 149
 None
 1.28A 2jc9A-5affA:
undetectable		 2jc9A-5affA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 6 HIS C  69
ASP A 404
ASP C 127
TYR C 129
 None
 1.28A 2lh8A-5affC:
undetectable		 2lh8A-5affC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 ILE A 201
VAL A 131
LEU A 135
PHE A 142
GLN A 150
 None
 1.33A 2no0A-5affA:
undetectable		 2no0A-5affA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 ILE A 201
VAL A 131
LEU A 135
PHE A 142
GLN A 150
 None
 1.38A 2no0B-5affA:
undetectable		 2no0B-5affA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 5 LEU A 167
LEU A 160
CYH A 208
THR A 211
 None
 1.24A 2oaxD-5affA:
undetectable		 2oaxD-5affA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 602
ASN A 603
LEU A 605
VAL A 667
MET A 637
 None
 1.38A 2q7iA-5affA:
undetectable		 2q7iA-5affA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 602
ASN A 603
LEU A 605
VAL A 667
MET A 637
 None
 1.39A 2q7kA-5affA:
undetectable		 2q7kA-5affA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 602
ASN A 603
LEU A 605
VAL A 667
MET A 637
 None
 1.39A 2q7lA-5affA:
undetectable		 2q7lA-5affA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V95_A_HCYA1375_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 ALA A 567
VAL A 563
THR A 585
ILE A 528
PHE A 582
 None
 1.09A 2v95A-5affA:
undetectable		 2v95A-5affA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.22A 2y69C-5affC:
undetectable
2y69J-5affC:
undetectable		 2y69C-5affC:
19.03
2y69J-5affC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.26A 2y69P-5affC:
undetectable
2y69W-5affC:
undetectable		 2y69P-5affC:
19.03
2y69W-5affC:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_1
(CATECHOL
O-METHYLTRANSFERASE)		 5aff SYMPORTIN 1
RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		3 / 3 SER C  23
GLU A 395
ASP A 405
 None
 0.79A 2zthA-5affC:
undetectable		 2zthA-5affC:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.21A 3abmC-5affC:
undetectable
3abmJ-5affC:
undetectable		 3abmC-5affC:
19.03
3abmJ-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.27A 3abmP-5affC:
undetectable
3abmW-5affC:
undetectable		 3abmP-5affC:
19.03
3abmW-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.20A 3ag3C-5affC:
undetectable
3ag3J-5affC:
undetectable		 3ag3C-5affC:
19.03
3ag3J-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 152
ALA A  59
ALA A  94
LEU A 166
LEU A 115
 None
 1.21A 3b0wB-5affA:
undetectable		 3b0wB-5affA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB501_2
(PHOSPHOLIPASE A2)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 11 VAL A 512
LEU A 513
ILE A 485
LYS A 483
THR A 476
 None
 1.07A 3bjwB-5affA:
undetectable		 3bjwB-5affA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 VAL A 512
LEU A 513
ILE A 485
LYS A 483
THR A 476
 None
 1.11A 3bjwF-5affA:
undetectable		 3bjwF-5affA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 11 VAL A 512
LEU A 513
ILE A 485
LYS A 483
THR A 476
 None
 1.10A 3bjwH-5affA:
undetectable		 3bjwH-5affA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 MET A 637
LEU A 630
ALA A 601
ALA A 656
GLY A 664
 None
 1.08A 3c6gB-5affA:
undetectable		 3c6gB-5affA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 THR A 322
LEU A 449
ILE A 469
VAL A 422
ILE A 480
 None
 1.03A 3frqB-5affA:
2.0		 3frqB-5affA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 7 GLY C 125
PHE C 128
GLY C 106
PHE C 105
 None
 0.91A 3ko0M-5affC:
undetectable
3ko0P-5affC:
undetectable		 3ko0M-5affC:
22.78
3ko0P-5affC:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 9 LEU A 209
VAL A 256
VAL A 219
GLY A 220
LEU A 235
 None
 1.28A 3lp0A-5affA:
undetectable		 3lp0A-5affA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 CYH A 273
HIS A 254
LEU A 417
ARG A 415
THR A 317
 None
 1.20A 3okxB-5affA:
undetectable		 3okxB-5affA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_1
(YAEB-LIKE PROTEIN
RPA0152)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 CYH A 273
LEU A 417
ARG A 415
GLY A 316
THR A 317
 None
 1.03A 3okxB-5affA:
undetectable		 3okxB-5affA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 630
GLU A 600
ALA A 601
LEU A 583
ALA A 596
 None
 1.21A 3ou6C-5affA:
undetectable		 3ou6C-5affA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 8 ASP C 112
GLY C 114
GLN A 424
GLU C 109
 None
 1.03A 3s3nA-5affC:
undetectable		 3s3nA-5affC:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 GLN A 553
GLY A 556
GLY A 554
SER A 533
GLU A 600
 None
 1.25A 3sxjA-5affA:
undetectable		 3sxjA-5affA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 GLN A 553
GLY A 556
GLY A 554
SER A 533
GLU A 600
 None
 1.24A 3sxjB-5affA:
undetectable		 3sxjB-5affA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 GLN A 553
GLY A 556
GLY A 554
SER A 533
GLU A 600
 None
 1.27A 3t7sB-5affA:
undetectable		 3t7sB-5affA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 GLN A 553
GLY A 556
GLY A 554
SER A 533
GLU A 600
 None
 1.22A 3t7sD-5affA:
undetectable		 3t7sD-5affA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQ9_A_MTXA2001_1
(DIHYDROFOLATE
REDUCTASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 ILE A 192
LEU A 135
LEU A 187
LEU A 161
THR A 229
 None
 0.99A 3tq9A-5affA:
undetectable		 3tq9A-5affA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 VAL A  62
LEU A 100
ILE A  79
LEU A  43
THR A  84
 None
 1.13A 4o5fA-5affA:
undetectable
4o5fB-5affA:
undetectable		 4o5fA-5affA:
19.91
4o5fB-5affA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		3 / 3 SER C 120
ASP C 118
GLN C  40
 None
 0.95A 4oltA-5affC:
undetectable
4oltB-5affC:
undetectable		 4oltA-5affC:
20.97
4oltB-5affC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 VAL A  62
LEU A  43
LEU A  81
LEU A 118
PHE A 111
 None
 1.41A 4rtbA-5affA:
undetectable		 4rtbA-5affA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 167
LEU A 160
LEU A 100
THR A  84
ALA A 127
 None
 1.17A 4x1kA-5affA:
undetectable
4x1kB-5affA:
2.6		 4x1kA-5affA:
20.66
4x1kB-5affA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 ASP A 401
LEU A 408
GLY A 406
 None
 0.54A 4xmfA-5affA:
undetectable		 4xmfA-5affA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 VAL A 422
LEU A 417
ILE A 452
GLY A 316
LEU A 323
 None
 1.05A 4y8wA-5affA:
undetectable		 4y8wA-5affA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 VAL A 422
LEU A 417
ILE A 452
GLY A 316
LEU A 323
 None
 1.12A 4y8wB-5affA:
undetectable		 4y8wB-5affA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 11 HIS A 444
SER A 447
THR A 311
GLY A 316
ALA A 448
 None
 1.38A 5cz7H-5affA:
undetectable
5cz7N-5affA:
undetectable		 5cz7H-5affA:
16.38
5cz7N-5affA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_B_0HKB1201_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 12 LEU A 555
THR A 500
THR A 503
ALA A 506
ASN A 450
 None
 1.23A 5dsgB-5affA:
undetectable		 5dsgB-5affA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		5 / 11 HIS A 444
SER A 447
THR A 311
GLY A 316
ALA A 448
 None
 1.37A 5l66H-5affA:
undetectable
5l66N-5affA:
undetectable		 5l66H-5affA:
16.38
5l66N-5affA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 9 ILE A  36
VAL A  76
ASP A  42
ILE A  58
 None
 1.01A 5lg3I-5affA:
4.8		 5lg3I-5affA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		4 / 7 ILE A 456
ILE A 452
THR A 476
ILE A 480
 None
 0.86A 5murB-5affA:
2.9		 5murB-5affA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.23A 5wauC-5affC:
undetectable
5wauJ-5affC:
undetectable		 5wauC-5affC:
19.03
5wauJ-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.23A 5wauc-5affC:
undetectable
5wauj-5affC:
undetectable		 5wauc-5affC:
19.03
5wauj-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.23A 5xdqC-5affC:
undetectable
5xdqJ-5affC:
undetectable		 5xdqC-5affC:
19.03
5xdqJ-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aff RIBOSOMAL PROTEIN
L11
(Chaetomium
thermophilum) 		4 / 5 PHE C 128
PHE C 105
LEU C  92
PHE C 163
 None
 1.24A 5xdqP-5affC:
undetectable
5xdqW-5affC:
undetectable		 5xdqP-5affC:
19.03
5xdqW-5affC:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5aff SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 LYS A  26
LEU A  28
ARG A  32
 None
 0.93A 5yw0A-5affA:
undetectable		 5yw0A-5affA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5aff RIBOSOMAL PROTEIN
L11
SYMPORTIN 1
(Chaetomium
thermophilum) 		3 / 3 TYR C 117
LEU A 431
ASP A 434
 None
 0.72A 5zv2B-5affC:
undetectable		 5zv2B-5affC:
22.52