SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5afo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_C_CCSC47_0
(GLUTATHIONE
S-TRANSFERASE)		 5afo FIMBRIAE
(Escherichia
coli) 		4 / 6 THR A  18
LEU A 133
GLY A 131
TYR A  40
 None
 1.32A 1gtiC-5afoA:
undetectable		 1gtiC-5afoA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5afo FIMBRIAE
(Escherichia
coli) 		3 / 3 ALA A 250
THR A 305
PHE A 349
 None
 0.57A 2c6nB-5afoA:
undetectable		 2c6nB-5afoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5afo FIMBRIAE
(Escherichia
coli) 		4 / 6 ILE A 152
ILE A 169
LEU A  73
PHE A  82
 None
 1.17A 3adsA-5afoA:
undetectable		 3adsA-5afoA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5afo FIMBRIAE
(Escherichia
coli) 		4 / 8 PRO A 283
VAL A 294
ASN A 225
ILE A 229
 None
 1.09A 4iilA-5afoA:
undetectable		 4iilA-5afoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YSI_A_NCAA1001_0
(UBIQUITINATING/DEUBI
QUITINATING ENZYME
SDEA)		 5afo FIMBRIAE
(Escherichia
coli) 		4 / 6 GLY A 128
SER A 154
THR A  69
VAL A  94
 None
 1.00A 5ysiA-5afoA:
undetectable		 5ysiA-5afoA:
17.42