SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5afu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 TRP J 387
ALA J 121
VAL J  95
 None
 0.84A 1av2C-5afuJ:
undetectable
1av2D-5afuJ:
undetectable		 1av2C-5afuJ:
2.93
1av2D-5afuJ:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 8 LEU A 337
VAL A  20
GLY A  19
TYR A 338
 None
ADP  A 800 ( 4.0A)
ADP  A 800 ( 4.0A)
None
 1.05A 1jlfA-5afuA:
undetectable
1jlfB-5afuA:
undetectable		 1jlfA-5afuA:
22.01
1jlfB-5afuA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 ALA J 121
VAL J  95
TRP J 387
 None
 1.02A 1tkqA-5afuJ:
undetectable		 1tkqA-5afuJ:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB6_0
(GRAMICIDIN D)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 TRP J 387
ALA J 121
VAL J  95
 None
 0.98A 1w5uA-5afuJ:
undetectable
1w5uB-5afuJ:
undetectable		 1w5uA-5afuJ:
2.93
1w5uB-5afuJ:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDA_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 10 HIS A 106
VAL A 108
PHE A 128
VAL A  12
THR A 101
 None
 1.39A 1ydaA-5afuA:
undetectable		 1ydaA-5afuA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 11 HIS A 106
VAL A 108
PHE A 128
VAL A  12
THR A 101
 None
 1.34A 1ydbA-5afuA:
undetectable		 1ydbA-5afuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YDD_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 10 HIS A 106
VAL A 108
PHE A 128
VAL A  12
THR A 101
 None
 1.36A 1yddA-5afuA:
undetectable		 1yddA-5afuA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 12 HIS A 166
ILE A 183
GLY A 274
VAL A 318
ILE A 298
 None
 1.07A 1zq9A-5afuA:
undetectable		 1zq9A-5afuA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 8 ALA A 149
SER A 331
LEU A 300
VAL A 299
 None
 0.84A 2bxgA-5afuA:
undetectable		 2bxgA-5afuA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 ALA J 121
VAL J  95
TRP J 387
 None
 0.92A 2izqA-5afuJ:
undetectable
2izqB-5afuJ:
undetectable		 2izqA-5afuJ:
2.93
2izqB-5afuJ:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 12 ILE J 284
ALA J 300
THR J 335
TYR J 332
LEU J 285
 None
 1.35A 2rctA-5afuJ:
undetectable		 2rctA-5afuJ:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IEO_A_AMJA300_0
(CARBONIC ANHYDRASE 2)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 4 ILE A 283
GLN A 284
VAL A 280
PHE A 295
 None
 0.92A 3ieoA-5afuA:
undetectable		 3ieoA-5afuA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 TRP J 387
ALA J 121
VAL J  95
 None
 0.95A 3l8lA-5afuJ:
undetectable
3l8lB-5afuJ:
undetectable		 3l8lA-5afuJ:
2.93
3l8lB-5afuJ:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 6 LEU J 120
GLU J  93
PRO J 122
ARG J 102
 None
 1.43A 3ltwA-5afuJ:
undetectable		 3ltwA-5afuJ:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 11 HIS A 106
VAL A 108
PHE A 128
VAL A  12
THR A 101
 None
 1.33A 3ml5A-5afuA:
undetectable		 3ml5A-5afuA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 8 ILE J 384
ALA J 121
LEU J 120
LEU J 109
 None
 0.83A 3ozwA-5afuJ:
undetectable		 3ozwA-5afuJ:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RET_A_SALA201_1
(SALICYLATE
BIOSYNTHESIS PROTEIN
PCHB)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 10 VAL A 318
ALA A 167
VAL A 156
ILE A 283
ILE A 330
 None
 1.20A 3retA-5afuA:
undetectable
3retB-5afuA:
undetectable		 3retA-5afuA:
12.95
3retB-5afuA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 5 GLY A 343
ILE A 346
TRP A 341
VAL A  13
 None
 1.21A 4d33B-5afuA:
undetectable		 4d33B-5afuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 11 ALA J 354
GLY J 308
GLY J 142
ILE J 306
GLU J 208
 None
ADP  J 800 ( 3.2A)
ADP  J 800 ( 3.1A)
None
ADP  J 800 ( 4.6A)
 1.11A 4dcmA-5afuJ:
undetectable		 4dcmA-5afuJ:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 12 PRO A  11
GLY A  27
ILE A 346
PHE A 353
LEU A 109
 None
 1.45A 4kotA-5afuA:
undetectable		 4kotA-5afuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 12 PRO A  11
GLY A  27
ILE A 346
PHE A 353
LEU A 109
 None
 1.47A 4kovA-5afuA:
undetectable		 4kovA-5afuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 7 ARG A 123
ILE A 371
LEU A 137
THR A 131
 None
 0.92A 4mmcA-5afuA:
undetectable		 4mmcA-5afuA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 8 ALA A 348
PRO A  11
VAL A  13
GLY A  27
 None
 0.69A 4zjzA-5afuA:
undetectable		 4zjzA-5afuA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 TYR J 332
LYS J 329
LYS J 331
 None
 1.34A 5dbyA-5afuJ:
0.5		 5dbyA-5afuJ:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_A_PPFA602_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 6 ARG A 192
ASP A 162
GLY A 187
ASP A 189
 None
ADP  A 800 ( 3.2A)
ADP  A 800 ( 4.7A)
None
 1.34A 5hp1A-5afuA:
undetectable		 5hp1A-5afuA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 GLN A 142
THR A 111
ASP A  15
 ADP  A 800 ( 4.4A)
None
None
 0.81A 5k9dA-5afuA:
undetectable		 5k9dA-5afuA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 5afu DYNACTIN
(Sus
scrofa) 		5 / 9 ASN A  37
ASP A 162
GLY A  78
ILE A  79
THR A 111
 None
ADP  A 800 ( 3.2A)
None
None
None
 1.25A 5kr2C-5afuA:
undetectable		 5kr2C-5afuA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 GLU A 210
HIS A 206
ARG A 199
 None
 0.76A 5uunA-5afuA:
undetectable		 5uunA-5afuA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 GLY A  17
ASN A  37
ARG A 188
 ADP  A 800 ( 3.1A)
None
None
 0.65A 5w7bD-5afuA:
undetectable		 5w7bD-5afuA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5afu DYNACTIN
(Sus
scrofa) 		3 / 3 ASP A 162
PHE A 211
ARG A 192
 ADP  A 800 ( 3.2A)
None
None
 0.87A 5yw0A-5afuA:
undetectable		 5yw0A-5afuA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 5 LEU J  20
THR J 106
PRO J  84
ARG J  87
 None
 1.40A 6ew0B-5afuJ:
undetectable		 6ew0B-5afuJ:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 5 LEU J  20
THR J 106
PRO J  84
ARG J  87
 None
 1.40A 6ew0D-5afuJ:
undetectable		 6ew0D-5afuJ:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 5 LEU J  20
THR J 106
PRO J  84
ARG J  87
 None
 1.40A 6ew0H-5afuJ:
undetectable		 6ew0H-5afuJ:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 5afu DYNACTIN
(Sus
scrofa) 		4 / 5 LEU J  20
THR J 106
PRO J  84
ARG J  87
 None
 1.40A 6ew0I-5afuJ:
undetectable		 6ew0I-5afuJ:
11.35