SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ag9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5ag9 GINGIPAIN R2
(Porphyromonas
gingivalis) 		5 / 10 VAL A 600
VAL A 660
VAL A 658
ASN A 633
ILE A 655
 None
 1.25A 1fe2A-5ag9A:
undetectable		 1fe2A-5ag9A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_B_RBFB596_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 5ag9 GINGIPAIN R2
(Porphyromonas
gingivalis) 		5 / 11 VAL A 676
VAL A 733
TYR A 718
GLU A 686
ILE A 694
 None
 1.32A 1t6zB-5ag9A:
undetectable		 1t6zB-5ag9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_B_TOPB200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ag9 GINGIPAIN R2
(Porphyromonas
gingivalis) 		5 / 12 ALA A 595
ASN A 633
LEU A 632
LEU A 642
VAL A 660
 None
 1.06A 3fl9B-5ag9A:
undetectable		 3fl9B-5ag9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_G_TOPG200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 5ag9 GINGIPAIN R2
(Porphyromonas
gingivalis) 		5 / 12 ALA A 595
ASN A 633
LEU A 632
LEU A 642
VAL A 660
 None
 1.09A 3fl9G-5ag9A:
undetectable		 3fl9G-5ag9A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_D_DXCD92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5ag9 GINGIPAIN R2
(Porphyromonas
gingivalis) 		4 / 5 VAL A 702
GLU A 639
LYS A 732
PHE A 711
 None
 1.32A 3rv5C-5ag9A:
undetectable
3rv5D-5ag9A:
undetectable		 3rv5C-5ag9A:
18.79
3rv5D-5ag9A:
18.79