SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5agt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		3 / 3 ALA A 367
VAL A 369
TRP A 365
 None
 1.02A 1gmkA-5agtA:
undetectable
1gmkB-5agtA:
undetectable		 1gmkA-5agtA:
8.70
1gmkB-5agtA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_A_SAMA300_0
(HEMK PROTEIN)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.94A 1nv8A-5agtA:
undetectable		 1nv8A-5agtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NV8_B_SAMB301_0
(HEMK PROTEIN)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.95A 1nv8B-5agtA:
undetectable		 1nv8B-5agtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.98A 1sg9B-5agtA:
undetectable		 1sg9B-5agtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_B_SAMB301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 THR A 341
ILE A 480
GLY A 479
GLY A 477
PRO A 493
 A2H  A1514 (-3.6A)
None
None
None
None
 0.98A 1vq1B-5agtA:
undetectable		 1vq1B-5agtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 318
PHE A 426
ALA A 454
PRO A 424
GLY A 458
 None
None
None
GOL  A1515 ( 4.9A)
None
 1.21A 2igtC-5agtA:
undetectable		 2igtC-5agtA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		4 / 8 VAL A 349
LYS A 405
GLY A 407
TYR A 387
 None
 0.88A 3af0A-5agtA:
undetectable		 3af0A-5agtA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 348
ASN A 416
THR A 341
VAL A 423
 None
None
A2H  A1514 (-3.6A)
GOL  A1515 (-4.3A)
 0.65A 3dcjB-5agtA:
undetectable		 3dcjB-5agtA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 11 THR A 341
ASN A 488
SER A 491
VAL A 492
ALA A 495
 A2H  A1514 (-3.6A)
None
None
None
None
 0.97A 3dcmX-5agtA:
undetectable		 3dcmX-5agtA:
26.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 347
PHE A 426
VAL A 349
VAL A 408
TRP A 373
 None
 1.39A 3km6B-5agtA:
undetectable		 3km6B-5agtA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR A 347
PHE A 426
VAL A 349
VAL A 408
TRP A 373
 None
 1.42A 3kmoA-5agtA:
undetectable		 3kmoA-5agtA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 334
LEU A 348
ILE A 332
LEU A 317
 None
 0.81A 4mghA-5agtA:
undetectable		 4mghA-5agtA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_A_29SA601_1
(ESTROGEN RECEPTOR)		 5agt LEUCINE--TRNA LIGASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 320
LEU A 317
ARG A 508
LEU A 350
PRO A 424
 None
None
None
None
GOL  A1515 ( 4.9A)
 1.32A 4xi3A-5agtA:
undetectable		 4xi3A-5agtA:
21.51