SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ah5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_B_DVAB2_0
(ACTINOMYCIN D)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 THR A 152
PRO A 187
THR A 186
 None
 0.89A 1a7yB-5ah5A:
undetectable		 1a7yB-5ah5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSC_C_DVAC2_0
(ACTINOMYCIN D)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 THR A 152
PRO A 187
THR A 186
 None
 0.88A 1dscC-5ah5A:
undetectable		 1dscC-5ah5A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3001_0
(BETA-CARBONIC
ANHYDRASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 CYH A 435
CYH A 473
GLY A 477
GLY A 478
 ZN  A 900 (-2.3A)
ZN  A 900 (-2.3A)
None
None
 0.89A 1ekjA-5ah5A:
undetectable
1ekjB-5ah5A:
undetectable		 1ekjA-5ah5A:
14.36
1ekjB-5ah5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3002_0
(BETA-CARBONIC
ANHYDRASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 CYH A 435
CYH A 473
GLY A 477
GLY A 478
 ZN  A 900 (-2.3A)
ZN  A 900 (-2.3A)
None
None
 0.88A 1ekjG-5ah5A:
undetectable
1ekjH-5ah5A:
undetectable		 1ekjG-5ah5A:
14.36
1ekjH-5ah5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 6 ARG A 596
GLY A 116
ASP A  58
TRP A  16
 None
 1.20A 1kf6M-5ah5A:
undetectable
1kf6N-5ah5A:
2.8		 1kf6M-5ah5A:
22.33
1kf6N-5ah5A:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 TRP A  77
HIS A  50
MET A 106
 None
LSS  A1818 (-4.0A)
None
 1.22A 1l5qB-5ah5A:
undetectable		 1l5qB-5ah5A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 PHE A 552
TYR A  34
PRO A 519
 None
 1.12A 1mcnA-5ah5A:
undetectable
1mcnB-5ah5A:
undetectable
1mcnP-5ah5A:
undetectable		 1mcnA-5ah5A:
16.12
1mcnB-5ah5A:
16.12
1mcnP-5ah5A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 LEU A 498
PHE A 497
VAL A 191
LEU A 137
LEU A 141
 None
 1.03A 1mx1B-5ah5A:
undetectable		 1mx1B-5ah5A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 117
ASN A  53
HIS A 533
GLY A 526
 None
LSS  A1818 (-3.4A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.5A)
 1.38A 1mxgA-5ah5A:
undetectable		 1mxgA-5ah5A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU3_A_MRCA993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLY A  49
HIS A  50
ASN A  53
SER A 493
VAL A 565
 LSS  A1818 (-3.3A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.4A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.67A 1qu3A-5ah5A:
29.7		 1qu3A-5ah5A:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 5 PRO A 583
VAL A 586
VAL A 595
ILE A  48
 None
 0.97A 1z2bC-5ah5A:
undetectable		 1z2bC-5ah5A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 VAL A 491
THR A 489
ILE A 509
ALA A 133
PHE A 497
 None
 1.25A 2admB-5ah5A:
undetectable		 2admB-5ah5A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.34A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.83A 2bteA-5ah5A:
46.5		 2bteA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.33A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.87A 2bteD-5ah5A:
39.7		 2bteD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		7 / 7 MET A  38
TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.31A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.81A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 523
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 1.47A 2bytA-5ah5A:
46.2		 2bytA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		7 / 7 MET A  38
TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.30A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.82A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 523
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 1.47A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 GLY A 305
ILE A 257
ALA A 243
THR A 331
ILE A 265
 None
 1.13A 2nnhA-5ah5A:
undetectable		 2nnhA-5ah5A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A 644
ILE A 658
LEU A 692
GLY A 706
ILE A 645
 None
 1.26A 2ogyA-5ah5A:
undetectable		 2ogyA-5ah5A:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A 644
ILE A 658
LEU A 692
GLY A 706
ILE A 645
 None
 1.25A 2ogyB-5ah5A:
undetectable		 2ogyB-5ah5A:
15.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 8 MET A  38
TYR A  41
ASP A  78
SER A 493
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.53A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.86A 2v0gA-5ah5A:
47.1		 2v0gA-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2V0G_D_LEUD1883_0
(AMINOACYL-TRNA
SYNTHETASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 5 TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
 0.36A 2v0gD-5ah5A:
46.1		 2v0gD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_0
(DIHYDROFOLATE
REDUCTASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 438
ALA A 441
LEU A 445
ILE A 427
PRO A 426
 None
 1.16A 2w3bB-5ah5A:
undetectable		 2w3bB-5ah5A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 ILE A 335
SER A 407
GLY A 332
GLY A 330
LEU A 259
 None
None
A  C  76 ( 4.7A)
A  C  76 ( 4.6A)
None
 1.27A 2zw9A-5ah5A:
undetectable		 2zw9A-5ah5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3COT_A_STRA1501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 7 TYR A 117
GLU A  37
TYR A 496
TRP A  77
 None
 1.43A 3cotA-5ah5A:
undetectable		 3cotA-5ah5A:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 593
LEU A 735
ILE A  21
PHE A 115
GLU A 724
 None
 1.27A 3ko0A-5ah5A:
undetectable
3ko0B-5ah5A:
undetectable
3ko0C-5ah5A:
undetectable
3ko0D-5ah5A:
undetectable		 3ko0A-5ah5A:
7.86
3ko0B-5ah5A:
7.86
3ko0C-5ah5A:
7.86
3ko0D-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.26A 3ko0C-5ah5A:
undetectable
3ko0D-5ah5A:
undetectable
3ko0E-5ah5A:
undetectable
3ko0F-5ah5A:
undetectable		 3ko0C-5ah5A:
7.86
3ko0D-5ah5A:
7.86
3ko0E-5ah5A:
7.86
3ko0F-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.24A 3ko0E-5ah5A:
undetectable
3ko0F-5ah5A:
undetectable
3ko0G-5ah5A:
undetectable
3ko0H-5ah5A:
undetectable		 3ko0E-5ah5A:
7.86
3ko0F-5ah5A:
7.86
3ko0G-5ah5A:
7.86
3ko0H-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.25A 3ko0G-5ah5A:
undetectable
3ko0H-5ah5A:
undetectable
3ko0I-5ah5A:
undetectable
3ko0J-5ah5A:
undetectable		 3ko0G-5ah5A:
7.86
3ko0H-5ah5A:
7.86
3ko0I-5ah5A:
7.86
3ko0J-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 ASP A 593
LEU A 735
ILE A  21
PHE A 115
GLU A 724
 None
 1.26A 3ko0G-5ah5A:
undetectable
3ko0H-5ah5A:
undetectable
3ko0I-5ah5A:
undetectable
3ko0J-5ah5A:
undetectable		 3ko0G-5ah5A:
7.86
3ko0H-5ah5A:
7.86
3ko0I-5ah5A:
7.86
3ko0J-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 735
ILE A  21
PHE A 115
GLU A 724
ASP A 593
 None
 1.22A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0S-5ah5A:
undetectable
3ko0T-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0S-5ah5A:
7.86
3ko0T-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A 724
LEU A 735
ILE A  21
PHE A 115
ASP A 593
 None
 1.25A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0M-5ah5A:
undetectable
3ko0N-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0M-5ah5A:
7.86
3ko0N-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 ASP A 593
GLU A 724
LEU A 735
ILE A  21
PHE A 115
 None
 1.27A 3ko0K-5ah5A:
undetectable
3ko0L-5ah5A:
undetectable
3ko0M-5ah5A:
undetectable
3ko0N-5ah5A:
undetectable		 3ko0K-5ah5A:
7.86
3ko0L-5ah5A:
7.86
3ko0M-5ah5A:
7.86
3ko0N-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 LEU A 735
ILE A  21
PHE A 115
GLU A 724
ASP A 593
 None
 1.27A 3ko0O-5ah5A:
undetectable
3ko0P-5ah5A:
undetectable
3ko0Q-5ah5A:
undetectable
3ko0R-5ah5A:
undetectable		 3ko0O-5ah5A:
7.86
3ko0P-5ah5A:
7.86
3ko0Q-5ah5A:
7.86
3ko0R-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 10 ASP A 593
LEU A 735
ILE A  21
PHE A 115
GLU A 724
 None
 1.27A 3ko0O-5ah5A:
undetectable
3ko0P-5ah5A:
undetectable
3ko0Q-5ah5A:
undetectable
3ko0R-5ah5A:
undetectable		 3ko0O-5ah5A:
7.86
3ko0P-5ah5A:
7.86
3ko0Q-5ah5A:
7.86
3ko0R-5ah5A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 10 TYR A 500
TYR A  34
ILE A 517
TYR A 496
ILE A 550
 None
 1.32A 3uprA-5ah5A:
undetectable		 3uprA-5ah5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 10 TYR A 500
TYR A  34
ILE A 517
TYR A 496
ILE A 550
 None
 1.33A 3uprC-5ah5A:
undetectable		 3uprC-5ah5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 792
LYS A 763
ARG A 796
 G  C  46 ( 4.7A)
None
None
 1.45A 3w1wA-5ah5A:
undetectable
3w1wB-5ah5A:
1.6		 3w1wA-5ah5A:
18.66
3w1wB-5ah5A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 796
ARG A 792
LYS A 763
 None
G  C  46 ( 4.7A)
None
 1.46A 3w1wA-5ah5A:
1.6
3w1wB-5ah5A:
1.6		 3w1wA-5ah5A:
18.66
3w1wB-5ah5A:
18.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_A_LEUA902_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		6 / 7 MET A  38
ASP A  78
SER A 493
GLU A 528
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
LSS  A1818 (-2.9A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.90A 4aq7A-5ah5A:
32.4		 4aq7A-5ah5A:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4AQ7_D_LEUD902_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		8 / 9 MET A  38
ASP A  78
SER A 493
TYR A 496
TYR A 523
GLU A 528
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-2.9A)
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.85A 4aq7D-5ah5A:
42.5		 4aq7D-5ah5A:
38.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		6 / 7 TYR A  41
ASP A  78
SER A 493
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-3.6A)
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.75A 4arcA-5ah5A:
43.2		 4arcA-5ah5A:
38.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7Q_A_ZMRA601_2
(NEURAMINIDASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 792
ARG A 796
ILE A 765
 G  C  46 ( 4.7A)
None
None
 0.94A 4b7qA-5ah5A:
undetectable		 4b7qA-5ah5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 714
SER A 723
PHE A 630
LEU A 704
VAL A 626
 None
 1.27A 4ib4A-5ah5A:
3.9		 4ib4A-5ah5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 CYH A 254
ALA A 243
GLY A 336
LEU A 353
ALA A 333
 None
 1.06A 4lg1C-5ah5A:
undetectable		 4lg1C-5ah5A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 LEU A 714
SER A 723
PHE A 630
LEU A 704
VAL A 626
 None
 1.24A 4nc3A-5ah5A:
2.7		 4nc3A-5ah5A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_B_032B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 5 ILE A 517
PHE A  22
SER A 502
ASP A  25
 None
 1.41A 4rzvB-5ah5A:
undetectable		 4rzvB-5ah5A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIL_H_QI9H1223_0
(FAB 314.1)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 TRP A 423
GLU A  85
GLY A  81
LEU A 462
PRO A 461
 None
 1.14A 4uilH-5ah5A:
undetectable
4uilL-5ah5A:
undetectable		 4uilH-5ah5A:
15.04
4uilL-5ah5A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 4 LEU A  46
ILE A  48
HIS A  47
VAL A  51
 None
 1.28A 4xyzA-5ah5A:
3.9		 4xyzA-5ah5A:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 6 SER A  43
SER A 105
ASP A 582
PRO A 583
 None
 1.17A 5c6pA-5ah5A:
undetectable		 5c6pA-5ah5A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 4 LEU A 139
TYR A 130
PRO A 426
ILE A 447
 None
 1.32A 5esgA-5ah5A:
undetectable		 5esgA-5ah5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 8 TRP A 175
GLU A 528
HIS A 533
THR A  99
 None
LSS  A1818 (-2.9A)
LSS  A1818 (-3.6A)
None
 1.47A 5hqaA-5ah5A:
undetectable		 5hqaA-5ah5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A  37
ASP A  58
GLY A 116
ALA A 120
ASN A 121
 None
 1.28A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 12 GLU A  37
LEU A  72
GLY A 116
ALA A 120
ASN A 121
 None
 1.41A 5kc0A-5ah5A:
undetectable		 5kc0A-5ah5A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 10 TYR A 500
TYR A  34
ILE A 517
TYR A 496
ILE A 550
 None
 1.33A 5u98A-5ah5A:
undetectable		 5u98A-5ah5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_D_1KXD301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 10 TYR A 500
TYR A  34
ILE A 517
TYR A 496
ILE A 550
 None
 1.32A 5u98D-5ah5A:
undetectable		 5u98D-5ah5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 5 TYR A 153
ARG A 185
THR A 264
LEU A 266
 None
 1.29A 5x1bJ-5ah5A:
undetectable		 5x1bJ-5ah5A:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		3 / 3 ARG A 596
PHE A  22
ARG A  62
 None
 1.18A 5y9yA-5ah5A:
undetectable		 5y9yA-5ah5A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_A_GM4A301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 ALA A 592
LEU A 715
TYR A   3
TRP A  16
ALA A 594
 None
 1.23A 6dk1A-5ah5A:
undetectable		 6dk1A-5ah5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 ALA A 592
LEU A 715
TYR A   3
TRP A  16
ALA A 594
 None
 1.41A 6dk1B-5ah5A:
undetectable		 6dk1B-5ah5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_C_GM4C301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		5 / 11 ALA A 592
LEU A 715
TYR A   3
TRP A  16
ALA A 594
 None
 1.39A 6dk1C-5ah5A:
undetectable		 6dk1C-5ah5A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 6 PRO A  40
ILE A 103
GLY A  76
GLU A 122
 LSS  A1818 (-4.3A)
None
None
None
 1.01A 6gqiA-5ah5A:
undetectable		 6gqiA-5ah5A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_A_H98A501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 4 ASP A  23
SER A  27
SER A  28
ASN A 121
 None
 1.44A 6iblA-5ah5A:
0.0		 6iblA-5ah5A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IBL_B_H98B501_1
(THIOREDOXIN 1,BETA-1
ADRENERGIC RECEPTOR)		 5ah5 LEUCINE--TRNA LIGASE
(Agrobacterium
tumefaciens) 		4 / 4 ASP A  23
SER A  27
SER A  28
ASN A 121
 None
 1.44A 6iblB-5ah5A:
undetectable		 6iblB-5ah5A:
19.78