SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ahk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_CCSB381_0
(ESTROGEN RECEPTOR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 GLU A 303
ALA A 320
SER A 323
None
0.54A 1errB-5ahkA:
undetectable
1errB-5ahkA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 4 LEU A 261
VAL A 273
CYH A 276
ALA A 302
None
1.22A 1mz9E-5ahkA:
undetectable
1mz9E-5ahkA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PKV_B_RBFB101_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 11 ILE A 441
VAL A 442
LEU A 538
ILE A 443
THR A 444
None
1.14A 1pkvA-5ahkA:
undetectable
1pkvB-5ahkA:
undetectable
1pkvA-5ahkA:
10.41
1pkvB-5ahkA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_0
(FATTY ACID-BINDING
PROTEIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 LEU A  37
ALA A  12
ASP A   5
ILE A 166
LEU A  98
None
1.08A 1tw4A-5ahkA:
undetectable
1tw4A-5ahkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_2
(ADENOSYLHOMOCYSTEINA
SE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 GLU A 384
THR A 383
LEU A 405
None
0.70A 1v8bC-5ahkA:
undetectable
1v8bC-5ahkA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_1
(MINERALOCORTICOID
RECEPTOR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 LEU A 163
LEU A  71
ALA A  70
LEU A  11
THR A 131
None
1.38A 1ya3A-5ahkA:
undetectable
1ya3A-5ahkA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 LEU A 163
LEU A  71
ALA A  70
LEU A  11
THR A 131
None
1.40A 2aa5B-5ahkA:
undetectable
2aa5B-5ahkA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
6 / 12 LEU A 126
LEU A 121
GLY A  77
ALA A  72
ALA A  70
ASP A 165
None
1.42A 2bm9F-5ahkA:
3.0
2bm9F-5ahkA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E7F_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 PHE A 298
ILE A 251
LEU A 231
GLY A 218
SER A 284
None
None
None
FAD  A 701 (-3.1A)
FAD  A 701 (-3.6A)
1.03A 2e7fB-5ahkA:
2.8
2e7fB-5ahkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 9 LEU A 280
LEU A 215
ILE A 217
LEU A 328
ILE A 307
None
None
None
FAD  A 701 (-3.8A)
None
1.16A 2f7aB-5ahkA:
2.1
2f7aB-5ahkA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 6 GLN A 233
GLU A 235
ILE A 234
PRO A 337
None
1.06A 2fcnA-5ahkA:
undetectable
2fcnB-5ahkA:
undetectable
2fcnA-5ahkA:
9.78
2fcnB-5ahkA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HC4_A_VDXA525_2
(VITAMIN D RECEPTOR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 7 LEU A 278
LEU A 279
ILE A 217
SER A 244
None
None
None
FAD  A 701 (-2.5A)
1.08A 2hc4A-5ahkA:
undetectable
2hc4A-5ahkA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1294_1
(FICOLIN-2)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 9 VAL A 222
GLY A 219
LEU A 216
SER A 244
LEU A 261
None
FAD  A 701 (-3.5A)
None
FAD  A 701 (-2.5A)
None
1.46A 2j2pB-5ahkA:
undetectable
2j2pC-5ahkA:
undetectable
2j2pB-5ahkA:
16.61
2j2pC-5ahkA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_B_C2FB4000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 PHE A 298
ILE A 251
LEU A 231
GLY A 218
SER A 284
None
None
None
FAD  A 701 (-3.1A)
FAD  A 701 (-3.6A)
1.02A 2ogyB-5ahkA:
2.8
2ogyB-5ahkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 10 PHE A 298
MET A 286
TYR A 257
VAL A 281
LEU A 279
None
1.39A 2w98A-5ahkA:
undetectable
2w98A-5ahkA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 10 LEU A 370
LEU A 527
LEU A 539
VAL A 541
ILE A 443
None
1.12A 2w9hA-5ahkA:
undetectable
2w9hA-5ahkA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 10 ALA A   6
ALA A   8
THR A  40
LEU A  69
VAL A  16
None
1.19A 2wuzA-5ahkA:
undetectable
2wuzA-5ahkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 10 ALA A   6
ALA A   8
THR A  40
LEU A  69
VAL A  16
None
1.17A 2wuzB-5ahkA:
undetectable
2wuzB-5ahkA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 PHE A  97
THR A  79
ASN A  80
GLY A  50
ALA A  52
None
1.25A 2x2iA-5ahkA:
undetectable
2x2iA-5ahkA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_C_2FAC500_2
(ADENOSYLHOMOCYSTEINA
SE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 5 LEU A 163
GLN A 101
THR A  99
THR A 128
None
1.36A 2zj0C-5ahkA:
undetectable
2zj0C-5ahkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_D_2FAD500_2
(ADENOSYLHOMOCYSTEINA
SE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 4 LEU A 163
GLN A 101
THR A  99
THR A 128
None
1.35A 2zj0D-5ahkA:
undetectable
2zj0D-5ahkA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 LEU A  11
GLY A  19
ILE A 151
LEU A  67
GLY A  68
None
1.00A 3axzA-5ahkA:
undetectable
3axzA-5ahkA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_A_BEZA261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 8 GLY A 395
ASN A 396
PHE A 482
TYR A 264
TPP  A 700 (-3.4A)
TPP  A 700 (-4.0A)
None
FAD  A 701 (-4.8A)
1.43A 3ccfA-5ahkA:
undetectable
3ccfA-5ahkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 ASN A 397
MET A 520
PHE A 376
TPP  A 700 (-4.0A)
None
None
1.01A 3g4lD-5ahkA:
undetectable
3g4lD-5ahkA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 SER A 284
LEU A 214
VAL A 242
ALA A 299
CYH A 276
FAD  A 701 (-3.6A)
None
None
None
None
1.39A 3u9fG-5ahkA:
undetectable
3u9fH-5ahkA:
undetectable
3u9fG-5ahkA:
15.61
3u9fH-5ahkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
1.39A 3w9tB-5ahkA:
undetectable
3w9tB-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
1.40A 3w9tC-5ahkA:
undetectable
3w9tC-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 5 ASP A  87
SER A 421
GLY A 420
ASP A  91
None
TPP  A 700 ( 4.2A)
FAD  A 701 (-3.7A)
FAD  A 701 ( 4.8A)
1.39A 3w9tD-5ahkA:
undetectable
3w9tD-5ahkA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 9 ASP A 393
GLY A 423
PHE A  53
THR A  83
GLY A  84
None
1.06A 4acaB-5ahkA:
2.1
4acaC-5ahkA:
3.2
4acaB-5ahkA:
25.41
4acaC-5ahkA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 GLN A 313
ASP A 287
GLN A 290
FAD  A 701 (-3.8A)
FAD  A 701 (-3.2A)
FAD  A 701 (-3.8A)
0.92A 4aztA-5ahkA:
undetectable
4aztA-5ahkA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 GLN A 450
LEU A 451
GLY A 445
ASN A 472
ASN A 396
None
None
TPP  A 700 (-3.6A)
None
TPP  A 700 (-4.0A)
1.34A 4pclB-5ahkA:
4.3
4pclB-5ahkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 11 ILE A  82
THR A  83
GLY A  84
THR A 131
VAL A 162
None
0.82A 4qgiA-5ahkA:
undetectable
4qgiA-5ahkA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 GLY A  84
GLN A  49
ILE A 430
ALA A 429
GLU A 249
None
1.05A 4r29D-5ahkA:
undetectable
4r29D-5ahkA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_D_QDND602_1
(CYTOCHROME P450 2D6)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 10 PHE A 424
GLY A 160
ALA A  52
SER A  56
ALA A  57
None
1.12A 4wnuD-5ahkA:
undetectable
4wnuD-5ahkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
6 / 12 ALA A 134
ILE A 130
THR A 131
TYR A 133
ALA A 150
GLY A  84
None
1.45A 5hesA-5ahkA:
undetectable
5hesA-5ahkA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
6 / 12 ALA A 134
ILE A 130
THR A 131
TYR A 133
ALA A 150
GLY A  84
None
1.44A 5hesB-5ahkA:
undetectable
5hesB-5ahkA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_B_ID8B602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 SER A 416
LEU A 405
MET A 413
None
0.79A 5ikrB-5ahkA:
undetectable
5ikrB-5ahkA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 GLY A  24
GLY A  25
GLN A 119
None
0.24A 5imsA-5ahkA:
42.0
5imsA-5ahkA:
33.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 7 GLY A 395
GLY A 445
GLY A 448
VAL A 394
LEU A 451
TPP  A 700 (-3.4A)
TPP  A 700 (-3.6A)
TPP  A 700 (-3.7A)
TPP  A 700 (-4.9A)
None
1.42A 5izjB-5ahkA:
undetectable
5izjB-5ahkA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 TYR A 257
PHE A 227
GLY A 218
HIS A 414
THR A  62
None
None
FAD  A 701 (-3.1A)
None
None
1.07A 5jlcA-5ahkA:
undetectable
5jlcA-5ahkA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_1
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 SER A  56
SER A  59
PHE A  97
None
0.94A 5mugA-5ahkA:
undetectable
5mugA-5ahkA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGB_B_PQNB844_1
(PSAB)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 9 ILE A 203
TRP A 349
ALA A 210
LEU A 278
ALA A 302
None
1.44A 5zgbB-5ahkA:
undetectable
5zgbB-5ahkA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZGH_B_PQNB843_1
(PSAB)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 9 ILE A 203
TRP A 349
ALA A 210
LEU A 278
ALA A 302
None
1.38A 5zghB-5ahkA:
undetectable
5zghB-5ahkA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 8 LEU A  71
LEU A  22
MET A  45
LEU A  81
None
1.15A 6cbzA-5ahkA:
undetectable
6cbzA-5ahkA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 TYR A 135
ASP A 165
GLN A 136
None
0.84A 6g1pA-5ahkA:
undetectable
6g1pA-5ahkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_A_ZOLA401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 7 ASP A 308
ARG A 158
GLN A 306
GLN A 290
FAD  A 701 (-2.9A)
FAD  A 701 (-3.9A)
None
FAD  A 701 (-3.8A)
1.49A 6g31A-5ahkA:
undetectable
6g31A-5ahkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G31_L_ZOLL401_0
(GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 6 ASP A  87
ASP A  91
GLN A 398
LYS A 246
None
FAD  A 701 ( 4.8A)
FAD  A 701 (-3.7A)
None
1.15A 6g31L-5ahkA:
undetectable
6g31L-5ahkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
5 / 12 GLY A 448
VAL A 470
THR A  83
GLY A  84
GLN A 454
TPP  A 700 (-3.7A)
None
None
None
None
1.19A 6gngA-5ahkA:
2.2
6gngA-5ahkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
3 / 3 ASP A  91
ASP A 393
ASN A 473
FAD  A 701 ( 4.8A)
None
MG  A 702 ( 2.6A)
0.86A 6gngB-5ahkA:
undetectable
6gngB-5ahkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 5 TYR A 257
VAL A 386
PHE A 227
GLY A 247
None
1.01A 6hd4A-5ahkA:
undetectable
6hd4A-5ahkA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens)
4 / 6 TYR A 257
VAL A 386
PHE A 227
GLY A 247
None
1.05A 6hd4B-5ahkA:
undetectable
6hd4B-5ahkA:
8.80