SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ahm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 6 VAL A 296
VAL A  45
ILE A 273
MET A  61
None
1.07A 1iepA-5ahmA:
undetectable
1iepA-5ahmA:
22.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_A_MOAA1332_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 11 ASN A 276
GLY A 299
CYH A 304
THR A 306
GLY A 388
IMP  A 501 ( 4.3A)
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
IMP  A 501 (-3.1A)
0.36A 1jr1A-5ahmA:
52.9
1jr1A-5ahmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 8 ASN A 276
GLY A 299
THR A 306
GLY A 388
IMP  A 501 ( 4.3A)
None
IMP  A 501 ( 4.9A)
IMP  A 501 (-3.1A)
0.30A 1jr1B-5ahmA:
52.8
1jr1B-5ahmA:
34.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ME7_A_MOAA600_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 8 ASN A 276
ILE A 298
GLY A 299
CYH A 304
GLY A 388
IMP  A 501 ( 4.3A)
None
None
IMP  A 501 (-3.0A)
IMP  A 501 (-3.1A)
0.43A 1me7A-5ahmA:
49.9
1me7A-5ahmA:
30.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RDD_A_AICA1110_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 4 LYS A 382
ALA A 364
PHE A 363
GLY A 360
None
None
None
IMP  A 501 (-3.7A)
1.44A 2rddA-5ahmA:
undetectable
2rddA-5ahmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 12 LEU A 327
VAL A 323
ILE A 320
GLY A 353
TYR A 355
None
1.31A 3hgiA-5ahmA:
undetectable
3hgiA-5ahmA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
3 / 3 ALA A 238
ARG A  84
LYS A  88
None
1.03A 3kp3B-5ahmA:
undetectable
3kp3B-5ahmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
3 / 3 ALA A 238
ARG A  84
LYS A  88
None
0.95A 3kp5B-5ahmA:
undetectable
3kp5B-5ahmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 6 VAL A 296
VAL A  45
ILE A 273
MET A  61
None
1.06A 3mssC-5ahmA:
undetectable
3mssC-5ahmA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_A_OBNA1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 11 ASP A 337
ASN A 276
VAL A 245
ILE A  69
ARG A 456
IMP  A 501 (-2.6A)
IMP  A 501 ( 4.3A)
None
None
None
1.21A 3n23A-5ahmA:
undetectable
3n23A-5ahmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.31A 3w9tA-5ahmA:
undetectable
3w9tA-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.30A 3w9tB-5ahmA:
undetectable
3w9tB-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.31A 3w9tC-5ahmA:
undetectable
3w9tC-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.31A 3w9tD-5ahmA:
undetectable
3w9tD-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.31A 3w9tE-5ahmA:
undetectable
3w9tE-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.31A 3w9tF-5ahmA:
undetectable
3w9tF-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
None
None
None
PO4  A1489 (-4.6A)
1.30A 3w9tG-5ahmA:
undetectable
3w9tG-5ahmA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 6 ALA A 293
PRO A 333
LEU A  34
THR A  35
None
0.95A 4dtzA-5ahmA:
undetectable
4dtzA-5ahmA:
19.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 8 ASN A 276
CYH A 304
THR A 306
MET A 387
GLY A 388
IMP  A 501 ( 4.3A)
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
0.26A 4fo4A-5ahmA:
55.1
4fo4A-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 8 ASP A 247
THR A 306
MET A 387
GLY A 388
None
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
0.88A 4fo4A-5ahmA:
55.1
4fo4A-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
6 / 8 ASN A 276
GLY A 299
CYH A 304
THR A 306
MET A 387
GLY A 388
IMP  A 501 ( 4.3A)
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
None
IMP  A 501 (-3.1A)
0.26A 4fo4B-5ahmA:
55.1
4fo4B-5ahmA:
65.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
7 / 9 ASP A 247
ASN A 276
ILE A 298
GLY A 299
CYH A 304
THR A 306
ASP A 337
None
IMP  A 501 ( 4.3A)
None
None
IMP  A 501 (-3.0A)
IMP  A 501 ( 4.9A)
IMP  A 501 (-2.6A)
0.30A 4fxsA-5ahmA:
57.4
4fxsA-5ahmA:
52.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 11 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.08A 4qvwK-5ahmA:
undetectable
4qvwL-5ahmA:
undetectable
4qvwK-5ahmA:
18.67
4qvwL-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 11 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.08A 4qvwY-5ahmA:
undetectable
4qvwZ-5ahmA:
undetectable
4qvwY-5ahmA:
18.67
4qvwZ-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 10 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.07A 4qw3K-5ahmA:
undetectable
4qw3L-5ahmA:
undetectable
4qw3K-5ahmA:
19.07
4qw3L-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 10 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.07A 4qw3Y-5ahmA:
undetectable
4qw3Z-5ahmA:
undetectable
4qw3Y-5ahmA:
19.07
4qw3Z-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 9 ALA A 278
ALA A 319
GLY A 251
GLY A 275
ASP A 337
None
None
None
None
IMP  A 501 (-2.6A)
1.14A 4qwuY-5ahmA:
undetectable
4qwuZ-5ahmA:
undetectable
4qwuY-5ahmA:
19.07
4qwuZ-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A 223
GLY A 275
ILE A 277
ILE A 298
GLN A 316
None
1.40A 4xucA-5ahmA:
undetectable
4xucA-5ahmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 12 VAL A 223
GLY A 275
ILE A 277
ILE A 298
GLN A 316
None
1.42A 4xudA-5ahmA:
undetectable
4xudA-5ahmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 9 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.07A 5d0xK-5ahmA:
undetectable
5d0xL-5ahmA:
undetectable
5d0xK-5ahmA:
20.55
5d0xL-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 9 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
None
1.07A 5d0xY-5ahmA:
undetectable
5d0xZ-5ahmA:
undetectable
5d0xY-5ahmA:
20.55
5d0xZ-5ahmA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 10 ILE A 432
LEU A 436
GLY A 360
ALA A 364
PHE A 363
None
None
IMP  A 501 (-3.7A)
None
None
1.04A 5mxbA-5ahmA:
undetectable
5mxbA-5ahmA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 12 ASP A 345
ALA A 354
GLY A 338
ARG A 341
VAL A 296
None
None
IMP  A 501 (-3.6A)
None
None
1.29A 6clxA-5ahmA:
undetectable
6clxA-5ahmA:
27.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 7 LEU A 334
LEU A 436
GLY A 344
GLY A 353
None
0.72A 6eu9D-5ahmA:
undetectable
6eu9D-5ahmA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
5 / 12 GLY A 386
GLY A 388
GLY A 371
ASN A  73
ARG A 385
IMP  A 501 (-3.1A)
IMP  A 501 (-3.1A)
None
None
None
0.99A 6gngB-5ahmA:
undetectable
6gngB-5ahmA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa)
4 / 6 LEU A 217
VAL A 223
MET A  61
GLY A  65
None
1.01A 6hd4B-5ahmA:
undetectable
6hd4B-5ahmA:
11.71