SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ahn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_A_STIA201_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 296
VAL A  45
ILE A 273
MET A  61
 None
 1.10A 1iepA-5ahnA:
undetectable		 1iepA-5ahnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A 327
VAL A 323
ILE A 320
GLY A 353
TYR A 355
 None
 1.33A 3hgiA-5ahnA:
undetectable		 3hgiA-5ahnA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		3 / 3 ALA A 238
ARG A  84
LYS A  88
 None
 1.09A 3kp5B-5ahnA:
undetectable		 3kp5B-5ahnA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_C_STIC1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 296
VAL A  45
ILE A 273
MET A  61
 None
 1.08A 3mssC-5ahnA:
undetectable		 3mssC-5ahnA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.30A 3w9tA-5ahnA:
undetectable		 3w9tA-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.29A 3w9tB-5ahnA:
undetectable		 3w9tB-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.30A 3w9tC-5ahnA:
undetectable		 3w9tC-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.30A 3w9tD-5ahnA:
undetectable		 3w9tD-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.29A 3w9tE-5ahnA:
undetectable		 3w9tE-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.30A 3w9tF-5ahnA:
undetectable		 3w9tF-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 242
VAL A 241
GLY A 240
ASP A 212
 None
 1.29A 3w9tG-5ahnA:
undetectable		 3w9tG-5ahnA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 ALA A 293
PRO A 333
LEU A  34
THR A  35
 None
 0.95A 4dtzA-5ahnA:
undetectable		 4dtzA-5ahnA:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 9 ASN A 276
ILE A 298
GLY A 299
CYH A 304
THR A 306
ASP A 337
 IMP  A1468 ( 4.4A)
None
None
None
None
IMP  A1468 (-2.6A)
 0.94A 4fxsA-5ahnA:
47.3		 4fxsA-5ahnA:
63.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FXS_A_MOAA702_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		6 / 9 ASP A 247
ASN A 276
ILE A 298
GLY A 299
THR A 306
ASP A 337
 None
IMP  A1468 ( 4.4A)
None
None
None
IMP  A1468 (-2.6A)
 0.51A 4fxsA-5ahnA:
47.3		 4fxsA-5ahnA:
63.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
 None
 1.11A 4qvwK-5ahnA:
undetectable
4qvwL-5ahnA:
undetectable		 4qvwK-5ahnA:
19.51
4qvwL-5ahnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ALA A 278
THR A 279
ALA A 319
GLY A 251
GLY A 275
 None
 1.11A 4qvwY-5ahnA:
undetectable
4qvwZ-5ahnA:
undetectable		 4qvwY-5ahnA:
19.51
4qvwZ-5ahnA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUC_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 223
GLY A 275
ILE A 277
ILE A 298
GLN A 316
 None
 1.36A 4xucA-5ahnA:
undetectable		 4xucA-5ahnA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUD_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		5 / 12 VAL A 223
GLY A 275
ILE A 277
ILE A 298
GLN A 316
 None
 1.38A 4xudA-5ahnA:
undetectable		 4xudA-5ahnA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 7 VAL A  86
PRO A  43
LEU A  30
MET A 359
 None
 0.91A 6aycA-5ahnA:
undetectable		 6aycA-5ahnA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LEU A 217
VAL A 223
MET A  61
GLY A  65
 None
 1.02A 6hd4B-5ahnA:
undetectable		 6hd4B-5ahnA:
10.66