SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aho'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 8 ASP A 145
ASP A 120
HIS A  31
HIS A 276
 None
ZN  A1320 (-2.5A)
ZN  A1321 (-3.3A)
TLA  A1319 ( 3.9A)
 1.00A 1ei6C-5ahoA:
undetectable		 1ei6C-5ahoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 8 ASP A 145
THR A 147
ASP A 120
HIS A  36
HIS A 276
 None
TLA  A1319 ( 4.7A)
ZN  A1320 (-2.5A)
ZN  A1320 ( 3.4A)
TLA  A1319 ( 3.9A)
 1.42A 1ei6C-5ahoA:
undetectable		 1ei6C-5ahoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 8 HIS A  31
ILE A 297
HIS A  99
HIS A  36
 ZN  A1321 (-3.3A)
None
ZN  A1321 ( 3.4A)
ZN  A1320 ( 3.4A)
 0.97A 1ei6D-5ahoA:
undetectable		 1ei6D-5ahoA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 7 GLY A 102
PRO A 101
ASP A 275
SER A 103
HIS A  99
 EDO  A1316 (-3.4A)
None
TLA  A1322 (-4.3A)
None
ZN  A1321 ( 3.4A)
 1.44A 1gxsA-5ahoA:
undetectable
1gxsB-5ahoA:
1.9		 1gxsA-5ahoA:
20.22
1gxsB-5ahoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 9 GLY A 102
PRO A 101
ASP A 275
SER A 103
HIS A  99
 EDO  A1316 (-3.4A)
None
TLA  A1322 (-4.3A)
None
ZN  A1321 ( 3.4A)
 1.41A 1gxsC-5ahoA:
undetectable
1gxsD-5ahoA:
undetectable		 1gxsC-5ahoA:
20.22
1gxsD-5ahoA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		3 / 3 ASP A  35
HIS A  99
ASP A 145
 TLA  A1319 ( 2.7A)
ZN  A1321 ( 3.4A)
None
 0.85A 1nw5A-5ahoA:
undetectable		 1nw5A-5ahoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 8 MET A 105
VAL A  92
PHE A 108
THR A 114
 None
 1.01A 2kotB-5ahoA:
undetectable		 2kotB-5ahoA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_B_BEZB500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 11 HIS A  31
HIS A 276
ASP A 120
HIS A  36
SER A   0
 ZN  A1321 (-3.3A)
TLA  A1319 ( 3.9A)
ZN  A1320 (-2.5A)
ZN  A1320 ( 3.4A)
None
 1.21A 2q0jB-5ahoA:
7.4		 2q0jB-5ahoA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 4 LEU A 144
ASP A  14
VAL A 298
THR A 147
 None
None
None
TLA  A1319 ( 4.7A)
 1.29A 3cyxB-5ahoA:
undetectable		 3cyxB-5ahoA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_C_MTXC164_2
(DIHYDROFOLATE
REDUCTASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 4 ILE A 177
ARG A 207
ILE A 229
THR A 251
 None
None
None
EDO  A1314 (-3.4A)
 1.15A 3ia4C-5ahoA:
undetectable		 3ia4C-5ahoA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		3 / 3 SER A 103
ASP A  96
ASP A 120
 None
EDO  A1316 (-3.8A)
ZN  A1320 (-2.5A)
 0.80A 3iv6A-5ahoA:
undetectable		 3iv6A-5ahoA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD392_1
(TETX2 PROTEIN)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 5 HIS A  36
SER A  30
SER A 103
VAL A 104
 ZN  A1320 ( 3.4A)
None
None
EDO  A1316 (-4.8A)
 1.44A 4a99D-5ahoA:
undetectable		 4a99D-5ahoA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 12 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.06A 4j6dA-5ahoA:
undetectable		 4j6dA-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 12 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.09A 4j6dB-5ahoA:
undetectable		 4j6dB-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 12 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.09A 4jbtA-5ahoA:
undetectable		 4jbtA-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 11 ALA A 284
ALA A 288
ALA A 287
VAL A 294
LEU A 144
 None
 1.10A 4jbtB-5ahoA:
undetectable		 4jbtB-5ahoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		3 / 3 ARG A 206
LEU A 210
GLU A 209
 None
 0.70A 4l3gF-5ahoA:
undetectable		 4l3gF-5ahoA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 11 HIS A  31
HIS A  33
ASP A  35
HIS A  36
HIS A  99
 ZN  A1321 (-3.3A)
ZN  A1321 ( 3.2A)
TLA  A1319 ( 2.7A)
ZN  A1320 ( 3.4A)
ZN  A1321 ( 3.4A)
 0.33A 5ayaA-5ahoA:
7.9		 5ayaA-5ahoA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 12 ASN A 148
HIS A 276
ASP A 120
ILE A 297
HIS A  36
 None
TLA  A1319 ( 3.9A)
ZN  A1320 (-2.5A)
None
ZN  A1320 ( 3.4A)
 1.31A 5dv4A-5ahoA:
undetectable		 5dv4A-5ahoA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA609_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		3 / 3 VAL A  64
SER A  41
TRP A  44
 None
EDO  A1318 (-2.9A)
None
 0.95A 5jwaA-5ahoA:
undetectable		 5jwaA-5ahoA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N1T_W_CUW201_0
(COPC)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		3 / 3 HIS A  99
ASP A 145
HIS A 276
 ZN  A1321 ( 3.4A)
None
TLA  A1319 ( 3.9A)
 0.90A 5n1tW-5ahoA:
undetectable		 5n1tW-5ahoA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 8 ASP A 120
HIS A  31
HIS A  36
ARG A 259
HIS A 276
 ZN  A1320 (-2.5A)
ZN  A1321 (-3.3A)
ZN  A1320 ( 3.4A)
None
TLA  A1319 ( 3.9A)
 1.11A 5nekB-5ahoA:
undetectable		 5nekB-5ahoA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		5 / 8 ASP A 120
HIS A  31
HIS A  36
ARG A 259
HIS A 276
 ZN  A1320 (-2.5A)
ZN  A1321 (-3.3A)
ZN  A1320 ( 3.4A)
None
TLA  A1319 ( 3.9A)
 1.10A 5nekD-5ahoA:
undetectable		 5nekD-5ahoA:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		6 / 10 HIS A  31
HIS A  33
HIS A  36
HIS A  99
ASP A 120
HIS A 276
 ZN  A1321 (-3.3A)
ZN  A1321 ( 3.2A)
ZN  A1320 ( 3.4A)
ZN  A1321 ( 3.4A)
ZN  A1320 (-2.5A)
TLA  A1319 ( 3.9A)
 0.24A 5nzwA-5ahoA:
20.8		 5nzwA-5ahoA:
35.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		6 / 10 HIS A  31
HIS A  33
HIS A  36
HIS A  99
ASP A 120
THR A 257
 ZN  A1321 (-3.3A)
ZN  A1321 ( 3.2A)
ZN  A1320 ( 3.4A)
ZN  A1321 ( 3.4A)
ZN  A1320 (-2.5A)
TLA  A1322 (-3.3A)
 0.66A 5nzwA-5ahoA:
20.8		 5nzwA-5ahoA:
35.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 8 PRO A  10
TYR A 111
TRP A  68
PRO A  47
 None
 1.35A 5x2sI-5ahoA:
undetectable
5x2sJ-5ahoA:
undetectable
5x2sK-5ahoA:
undetectable		 5x2sI-5ahoA:
17.27
5x2sJ-5ahoA:
19.80
5x2sK-5ahoA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 5 HIS A  36
SER A  30
GLY A 119
TYR A 117
 ZN  A1320 ( 3.4A)
None
None
None
 1.27A 5yodB-5ahoA:
undetectable		 5yodB-5ahoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_H_BEZH201_0
(NS3 PROTEASE)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 5 HIS A  36
SER A  30
GLY A 119
TYR A 117
 ZN  A1320 ( 3.4A)
None
None
None
 1.25A 5yodH-5ahoA:
undetectable		 5yodH-5ahoA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5aho 5' EXONUCLEASE
APOLLO
(Homo
sapiens) 		4 / 5 LEU A 195
GLN A 198
PHE A 197
PHE A 220
 None
 1.45A 6nmpP-5ahoA:
undetectable
6nmpW-5ahoA:
undetectable		 6nmpP-5ahoA:
22.35
6nmpW-5ahoA:
9.85