SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ahr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 8 ASP A 838
THR A 840
ASP A 815
HIS A 737
HIS A 994
 None
None
ZN  A2041 (-3.1A)
ZN  A2041 ( 4.8A)
None
 1.47A 1ei6C-5ahrA:
undetectable		 1ei6C-5ahrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 11 ARG A1002
LYS A1008
VAL A 832
GLN A 830
GLY A 807
 None
None
EDO  A2042 ( 4.7A)
None
None
 1.32A 3bf6H-5ahrA:
undetectable		 3bf6H-5ahrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		4 / 6 ALA A 862
ILE A 890
LEU A 894
ALA A 872
 None
 0.88A 3r9sC-5ahrA:
undetectable		 3r9sC-5ahrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_B_9PLB1_1
(CYTOCHROME P450 2A13)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 745
PHE A 717
ALA A 716
THR A 713
 None
 1.06A 3t3sB-5ahrA:
undetectable		 3t3sB-5ahrA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PAH_A_LNRA600_1
(PHENYLALANINE
HYDROXYLASE)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		4 / 6 LEU A 911
HIS A 734
HIS A 793
GLU A 993
 None
ZN  A2041 (-3.1A)
ZN  A2041 (-3.4A)
None
 1.05A 4pahA-5ahrA:
undetectable		 4pahA-5ahrA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		3 / 3 ILE A 913
PRO A 914
ILE A 916
 None
 0.45A 5hw8F-5ahrA:
undetectable		 5hw8F-5ahrA:
15.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		9 / 10 HIS A 732
HIS A 734
ASP A 736
HIS A 737
HIS A 793
ASP A 815
TYR A 841
TYR A 879
HIS A 994
 ZN  A2041 (-3.4A)
ZN  A2041 (-3.1A)
None
ZN  A2041 ( 4.8A)
ZN  A2041 (-3.4A)
ZN  A2041 (-3.1A)
None
None
None
 0.58A 5nzwA-5ahrA:
20.3		 5nzwA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 10 HIS A 793
HIS A 732
HIS A 994
ASP A 815
TYR A 879
 ZN  A2041 (-3.4A)
ZN  A2041 (-3.4A)
None
ZN  A2041 (-3.1A)
None
 1.05A 5nzwA-5ahrA:
20.3		 5nzwA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 8 ASN A 938
PHE A 939
THR A 962
ILE A 986
GLY A 988
 None
 0.58A 5nzxA-5ahrA:
48.0		 5nzxA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZX_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 8 PHE A 939
THR A 962
GLN A 979
ILE A 986
GLY A 988
 None
 1.03A 5nzxA-5ahrA:
48.0		 5nzxA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		6 / 7 ASN A 938
PHE A 939
ARG A 960
THR A 962
ILE A 986
GLY A 988
 None
 0.60A 5nzyA-5ahrA:
47.6		 5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		6 / 8 THR A 700
PRO A 702
TYR A 704
GLN A 718
ASP A 736
VAL A1018
 None
 0.59A 5nzyA-5ahrA:
47.6		 5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		6 / 8 THR A 700
PRO A 702
TYR A 704
GLN A 718
VAL A1018
GLY A1019
 None
 0.57A 5nzyA-5ahrA:
47.6		 5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		5 / 8 THR A 700
PRO A 702
VAL A1018
GLY A1019
ARG A1024
 None
 0.61A 5nzyA-5ahrA:
47.6		 5nzyA-5ahrA:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Q1S_A_AWYA1103_0
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ahr DNA CROSS-LINK
REPAIR 1A PROTEIN
(Homo
sapiens) 		6 / 6 LYS A 831
VAL A1004
LYS A1008
ILE A1012
LYS A1035
TYR A1040
 None
 0.48A 5q1sA-5ahrA:
45.6		 5q1sA-5ahrA:
99.42