SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aid'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5aid MEP2
(Candida
albicans) 		5 / 9 ALA A 362
PHE A 181
SER A 309
ILE A 297
THR A 367
 None
 1.00A 1j3jB-5aidA:
undetectable		 1j3jB-5aidA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JFF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.11A 1jffB-5aidA:
undetectable		 1jffB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5aid MEP2
(Candida
albicans) 		4 / 7 PHE A 231
MET A 227
VAL A 226
SER A 223
 None
 1.11A 1wrlA-5aidA:
undetectable
1wrlB-5aidA:
undetectable		 1wrlA-5aidA:
10.88
1wrlB-5aidA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXF_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.12A 2hxfB-5aidA:
undetectable		 2hxfB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HXH_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.12A 2hxhB-5aidA:
undetectable		 2hxhB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_A_DVAA6_0
(GRAMICIDIN D)		 5aid MEP2
(Candida
albicans) 		3 / 3 ALA A 194
VAL A 398
TRP A 394
 None
 0.87A 2izqA-5aidA:
undetectable
2izqB-5aidA:
undetectable		 2izqA-5aidA:
7.37
2izqB-5aidA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 5aid MEP2
(Candida
albicans) 		6 / 12 TYR A 253
ALA A 300
GLY A 302
VAL A 361
ASN A 240
PHE A 312
 None
 1.42A 2okcA-5aidA:
undetectable		 2okcA-5aidA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P4N_B_TA1B601_1
(TUBULIN BETA CHAIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.11A 2p4nB-5aidA:
undetectable		 2p4nB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 5aid MEP2
(Candida
albicans) 		4 / 8 SER A 199
VAL A 344
GLY A 343
TRP A 339
 None
 0.91A 2qd3A-5aidA:
undetectable		 2qd3A-5aidA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 5aid MEP2
(Candida
albicans) 		5 / 11 GLY A 345
GLY A 349
ILE A 319
ALA A 323
THR A 298
 None
 1.28A 2vdvF-5aidA:
undetectable		 2vdvF-5aidA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WBE_B_TA1B1439_1
(TUBULIN BETA-2B
CHAIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.11A 2wbeB-5aidA:
undetectable		 2wbeB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 5aid MEP2
(Candida
albicans) 		5 / 9 ALA A 317
VAL A 315
GLY A 293
GLY A 296
ILE A 311
 None
 0.98A 2z0yA-5aidA:
undetectable		 2z0yA-5aidA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5aid MEP2
(Candida
albicans) 		4 / 6 THR A   6
PHE A   5
GLN A  22
LEU A  19
 None
 1.18A 3bgdA-5aidA:
undetectable		 3bgdA-5aidA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 5aid MEP2
(Candida
albicans) 		4 / 4 LEU A 355
ASP A 359
VAL A 304
THR A 308
 None
 1.27A 3cyxB-5aidA:
undetectable		 3cyxB-5aidA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 5aid MEP2
(Candida
albicans) 		4 / 5 ALA A 405
ALA A 197
TYR A 198
MET A 134
 None
 1.29A 3d91A-5aidA:
undetectable		 3d91A-5aidA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCO_B_TA1B601_1
(BOVINE BETA TUBULIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.12A 3dcoB-5aidA:
undetectable		 3dcoB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.12A 3edlB-5aidA:
undetectable		 3edlB-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 381
LEU A 355
THR A 353
PRO A 316
GLY A 345
 None
 1.06A 3iz0B-5aidA:
undetectable		 3iz0B-5aidA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGT_B_CP6B609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5aid MEP2
(Candida
albicans) 		5 / 10 ALA A 362
PHE A 181
SER A 309
ILE A 297
THR A 367
 None
 1.01A 3qgtB-5aidA:
undetectable		 3qgtB-5aidA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5aid MEP2
(Candida
albicans) 		5 / 12 GLY A 372
GLY A 354
THR A 353
LYS A 379
TYR A 383
 None
 0.98A 3sglA-5aidA:
undetectable		 3sglA-5aidA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5aid MEP2
(Candida
albicans) 		5 / 11 GLY A 313
ALA A 292
GLY A 293
VAL A 348
CYH A 320
 None
 1.43A 4c5lA-5aidA:
undetectable		 4c5lA-5aidA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5aid MEP2
(Candida
albicans) 		5 / 10 GLY A 313
ALA A 292
GLY A 293
VAL A 348
CYH A 320
 None
 1.42A 4c5lC-5aidA:
undetectable		 4c5lC-5aidA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5aid MEP2
(Candida
albicans) 		5 / 10 GLY A 313
ALA A 292
GLY A 293
VAL A 348
CYH A 320
 None
 1.38A 4c5lD-5aidA:
undetectable		 4c5lD-5aidA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 5aid MEP2
(Candida
albicans) 		5 / 11 ASP A 180
VAL A 304
ALA A 358
TYR A 303
GLY A 372
 None
 1.08A 4mmaA-5aidA:
undetectable		 4mmaA-5aidA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5aid MEP2
(Candida
albicans) 		4 / 5 ASN A 350
PRO A 299
GLY A 185
ASP A 365
 None
 1.08A 4n48B-5aidA:
undetectable		 4n48B-5aidA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5aid MEP2
(Candida
albicans) 		5 / 12 GLY A 242
GLY A 245
SER A 247
SER A  35
ALA A  34
 None
 0.98A 4qtuD-5aidA:
undetectable		 4qtuD-5aidA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5aid MEP2
(Candida
albicans) 		5 / 12 PHE A 119
TYR A 122
PHE A  85
THR A 166
THR A 156
 None
 1.14A 5eskA-5aidA:
undetectable		 5eskA-5aidA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 5aid MEP2
(Candida
albicans) 		5 / 12 GLY A 293
TYR A  49
GLY A 346
THR A 298
LEU A 294
 None
 1.13A 5hg0A-5aidA:
undetectable		 5hg0A-5aidA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5aid MEP2
(Candida
albicans) 		5 / 12 ALA A  86
THR A   8
LEU A  83
ASN A  98
LEU A  96
 None
 1.13A 5nfjB-5aidA:
undetectable		 5nfjB-5aidA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 5aid MEP2
(Candida
albicans) 		5 / 12 ALA A  86
THR A   8
LEU A  83
ASN A  98
LEU A  96
 None
 1.13A 5nfjC-5aidA:
undetectable		 5nfjC-5aidA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5aid MEP2
(Candida
albicans) 		3 / 3 GLY A  32
THR A  10
PRO A 115
 None
 0.63A 5v5zA-5aidA:
undetectable		 5v5zA-5aidA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MHT_D_SAMD328_0
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI)		 5aid MEP2
(Candida
albicans) 		5 / 12 LEU A 196
GLY A 192
ASP A 407
ILE A 414
VAL A 338
 None
 1.12A 6mhtA-5aidA:
undetectable		 6mhtA-5aidA:
20.04