SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5aj1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A  50
VAL A  32
GLY A  29
TYR A  47
 None
 0.97A 1jlfA-5aj1A:
undetectable
1jlfB-5aj1A:
undetectable		 1jlfA-5aj1A:
12.39
1jlfB-5aj1A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWE_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		4 / 7 LEU A  50
VAL A  32
GLY A  29
TYR A  47
 None
 0.90A 1lweA-5aj1A:
undetectable		 1lweA-5aj1A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		4 / 8 LEU A  50
VAL A  32
GLY A  29
TYR A  47
 None
 0.94A 1s1xA-5aj1A:
undetectable		 1s1xA-5aj1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		4 / 5 LYS A  13
PRO A  14
SER A  30
SER A  67
 None
 1.27A 3iluH-5aj1A:
undetectable		 3iluH-5aj1A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
 None
 1.48A 3qipA-5aj1A:
undetectable		 3qipA-5aj1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3O_A_EFZA1557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		5 / 9 LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
 None
 1.42A 4b3oA-5aj1A:
undetectable		 4b3oA-5aj1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		5 / 11 LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
 None
 1.44A 5hbmA-5aj1A:
undetectable		 5hbmA-5aj1A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSJ_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 5aj1 SWI/SNF-RELATED
MATRIX-ASSOCIATED
ACTIN-DEPENDENT
REGULATOR OF
CHROMATIN SUBFAMILY
B MEMBER 1
(Homo
sapiens) 		5 / 10 LEU A  36
TYR A  47
GLY A  29
LEU A 100
TYR A  35
 None
 1.45A 6bsjA-5aj1A:
undetectable		 6bsjA-5aj1A:
20.69