SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ajz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 LEU A 137
ILE A 136
ALA A 147
ILE A 150
 None
 0.88A 1oniB-5ajzA:
undetectable
1oniC-5ajzA:
undetectable		 1oniB-5ajzA:
13.85
1oniC-5ajzA:
13.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		12 / 12 PRO A  43
LYS A  47
THR A  48
ASN A  69
GLY A  71
ARG A  75
PHE A  87
ARG A  98
ALA A 125
THR A 126
ARG A 189
TYR A 193
 PO4  A1448 (-4.5A)
PO4  A1448 (-2.7A)
PO4  A1448 (-3.9A)
None
None
None
None
None
None
None
None
None
 0.37A 2axnA-5ajzA:
55.8		 2axnA-5ajzA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMQ_A_BEZA3_0
(PROTEIN NDRG2)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 TYR A  81
PHE A  86
ARG A 189
ARG A  74
 None
 1.35A 2qmqA-5ajzA:
undetectable		 2qmqA-5ajzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 PHE A 284
LEU A 394
LEU A 250
PHE A 398
THR A 297
 None
 1.19A 2v0mC-5ajzA:
undetectable		 2v0mC-5ajzA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 6 LEU A 346
GLU A 342
PRO A 341
ARG A   8
 None
 1.33A 3ltwA-5ajzA:
undetectable		 3ltwA-5ajzA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		5 / 12 LEU A 391
LEU A 395
SER A 430
GLN A 388
HIS A 441
 None
None
None
F6P  A1447 ( 4.0A)
None
 1.27A 3m7rA-5ajzA:
undetectable		 3m7rA-5ajzA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 6 GLU A 360
ILE A 323
GLU A 322
ASN A 321
 None
None
F6P  A1447 (-3.5A)
None
 0.99A 3pgyA-5ajzA:
2.4
3pgyB-5ajzA:
2.2		 3pgyA-5ajzA:
21.41
3pgyB-5ajzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 4 ILE A 136
VAL A 122
VAL A  38
ARG A 133
 None
 1.20A 4m6tA-5ajzA:
undetectable		 4m6tA-5ajzA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 PRO A 407
MET A 406
TYR A 352
 None
 1.01A 4qa0B-5ajzA:
undetectable		 4qa0B-5ajzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 PRO A 407
MET A 406
TYR A 352
 None
 1.07A 4qa0A-5ajzA:
undetectable		 4qa0A-5ajzA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 LYS A  53
ASP A 400
ILE A  37
 None
 0.89A 5kc4E-5ajzA:
undetectable		 5kc4E-5ajzA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 8 LEU A 369
LEU A 391
ILE A 304
THR A 303
 None
 0.98A 5ljbA-5ajzA:
undetectable		 5ljbA-5ajzA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		4 / 7 SER A 437
HIS A 253
GLY A 254
ARG A 252
 None
PHS  A1446 (-3.4A)
None
PHS  A1446 (-3.5A)
 1.16A 6btxA-5ajzA:
undetectable		 6btxA-5ajzA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3
(Homo
sapiens) 		3 / 3 ARG A  74
GLY A  71
GLU A  72
 None
 0.54A 6fgdA-5ajzA:
undetectable		 6fgdA-5ajzA:
20.86