SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5akr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1OE1_A_CUA501_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.24A	1oe1A-5akrA: 53.3	1oe1A-5akrA: 62.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1OE2_A_CUA501_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 5	HIS A 95 CYH A 136 PRO A 138 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) None CU A 501 (-3.1A) CU A 501 (-2.4A)	0.24A	1oe2A-5akrA: 53.3	1oe2A-5akrA: 61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1OE3_A_CUA501_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.24A	1oe3A-5akrA: 52.7	1oe3A-5akrA: 62.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QU3_A_MRCA993_1 (ISOLEUCYL-TRNA SYNTHETASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 12	HIS A 100 HIS A 135 ASN A 151 GLN A 247 LYS A 269	CU A 502 (-3.2A) CU A 502 (-3.2A) None None None	1.28A	1qu3A-5akrA: undetectable	1qu3A-5akrA: 17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1TD2_A_PXLA288_1 (PYRIDOXAMINE KINASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 10	SER A 246 VAL A 133 ALA A 248 HIS A 135 VAL A 146	None None None CU A 502 (-3.2A) None	1.47A	1td2A-5akrA: undetectable	1td2A-5akrA: 22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FQD_A_CUA601_0 (BLUE COPPER OXIDASE CUEO)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.64A	2fqdA-5akrA: 20.5	2fqdA-5akrA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FQE_A_CUA601_0 (BLUE COPPER OXIDASE CUEO)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.61A	2fqeA-5akrA: 20.5	2fqeA-5akrA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FQF_A_CUA601_0 (BLUE COPPER OXIDASE CUEO)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.60A	2fqfA-5akrA: 20.5	2fqfA-5akrA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FQG_A_CUA601_0 (BLUE COPPER OXIDASE CUEO)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.61A	2fqgA-5akrA: 20.5	2fqgA-5akrA: 22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYU_A_SAMA201_0 (PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 12	GLY A 289 GLY A 286 ALA A 248 VAL A 264 LEU A 242	None	1.00A	2nyuA-5akrA: undetectable	2nyuA-5akrA: 18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2XXG_A_CUA1337_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.28A	2xxgA-5akrA: 53.0	2xxgA-5akrA: 61.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2XXG_C_CUC1338_0 (DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 5	HIS A 95 CYH A 136 PRO A 138 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) None CU A 501 (-3.1A) CU A 501 (-2.4A)	0.29A	2xxgC-5akrA: 52.9	2xxgC-5akrA: 61.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3APV_B_TP0B190_1 (ALPHA-1-ACID GLYCOPROTEIN 2)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 12	PHE A 320 TYR A 303 LEU A 72 HIS A 245 ALA A 291	None	1.49A	3apvB-5akrA: undetectable	3apvB-5akrA: 19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HKU_A_TORA300_2 (CARBONIC ANHYDRASE 2)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	3 / 3	GLU A 180 HIS A 245 THR A 252	None	0.80A	3hkuA-5akrA: undetectable	3hkuA-5akrA: 23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EF3_A_CUA1001_0 (BLUE COPPER OXIDASE CUEO)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 4	HIS A 95 CYH A 136 HIS A 145 MET A 150	CU A 501 (-3.1A) CU A 501 (-2.2A) CU A 501 (-3.1A) CU A 501 (-2.4A)	0.60A	4ef3A-5akrA: 20.4	4ef3A-5akrA: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4HVC_B_HFGB1602_1 (BIFUNCTIONAL GLUTAMATE/PROLINE--T RNA LIGASE)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 5	HIS A 60 THR A 92 GLU A 47 HIS A 145	None ACT A 601 ( 4.9A) None CU A 501 (-3.1A)	1.18A	4hvcB-5akrA: undetectable	4hvcB-5akrA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R7I_A_STIA1001_2 (MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 5	LEU A 256 VAL A 264 VAL A 244 TYR A 293	None	1.05A	4r7iA-5akrA: undetectable	4r7iA-5akrA: 21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KPR_A_PAUA404_0 (PANTOTHENATE KINASE 3)	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	4 / 5	GLU A 55 GLY A 315 ARG A 54 GLY A 225	None None None ACT A 506 ( 3.4A)	1.12A	5kprA-5akrA: undetectable	5kprA-5akrA: 22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TUI_B_CTCB405_0 (TETRACYCLINE DESTRUCTASE TET(50))	5akr	COPPER-CONTAINING NITRITE REDUCTASE (Achromobacter cycloclastes)	5 / 12	GLY A 152 LEU A 19 PHE A 124 VAL A 81 ILE A 154	None	1.27A	5tuiB-5akrA: undetectable	5tuiB-5akrA: 22.27

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1OE1_A_CUA501_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.24A","1oe1A-5akrA:53.3","1oe1A-5akrA:62.23"],["1OE2_A_CUA501_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"HIS A  95;CYH A 136;PRO A 138;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A);None; CU A 501 (-3.1A); CU A 501 (-2.4A)","0.24A","1oe2A-5akrA:53.3","1oe2A-5akrA:61.97"],["1OE3_A_CUA501_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.24A","1oe3A-5akrA:52.7","1oe3A-5akrA:62.23"],["1QU3_A_MRCA993_1","ISOLEUCYL-TRNA SYNTHETASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"HIS A 100;HIS A 135;ASN A 151;GLN A 247;LYS A 269"," CU A 502 (-3.2A); CU A 502 (-3.2A);None;None;None","1.28A","1qu3A-5akrA:undetectable","1qu3A-5akrA:17.61"],["1TD2_A_PXLA288_1","PYRIDOXAMINE KINASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"SER A 246;VAL A 133;ALA A 248;HIS A 135;VAL A 146","None;None;None; CU A 502 (-3.2A);None","1.47A","1td2A-5akrA:undetectable","1td2A-5akrA:22.19"],["2FQD_A_CUA601_0","BLUE COPPER OXIDASE CUEO","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.64A","2fqdA-5akrA:20.5","2fqdA-5akrA:22.38"],["2FQE_A_CUA601_0","BLUE COPPER OXIDASE CUEO","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.61A","2fqeA-5akrA:20.5","2fqeA-5akrA:22.38"],["2FQF_A_CUA601_0","BLUE COPPER OXIDASE CUEO","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.60A","2fqfA-5akrA:20.5","2fqfA-5akrA:22.38"],["2FQG_A_CUA601_0","BLUE COPPER OXIDASE CUEO","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.61A","2fqgA-5akrA:20.5","2fqgA-5akrA:22.38"],["2NYU_A_SAMA201_0","PUTATIVE RIBOSOMAL RNA METHYLTRANSFERASE 2","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"GLY A 289;GLY A 286;ALA A 248;VAL A 264;LEU A 242","None","1.00A","2nyuA-5akrA:undetectable","2nyuA-5akrA:18.09"],["2XXG_A_CUA1337_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.28A","2xxgA-5akrA:53.0","2xxgA-5akrA:61.97"],["2XXG_C_CUC1338_0","DISSIMILATORY COPPER-CONTAINING NITRITE REDUCTASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"HIS A  95;CYH A 136;PRO A 138;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A);None; CU A 501 (-3.1A); CU A 501 (-2.4A)","0.29A","2xxgC-5akrA:52.9","2xxgC-5akrA:61.97"],["3APV_B_TP0B190_1","ALPHA-1-ACID GLYCOPROTEIN 2","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"PHE A 320;TYR A 303;LEU A  72;HIS A 245;ALA A 291","None","1.49A","3apvB-5akrA:undetectable","3apvB-5akrA:19.53"],["3HKU_A_TORA300_2","CARBONIC ANHYDRASE 2","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",3,"GLU A 180;HIS A 245;THR A 252","None","0.80A","3hkuA-5akrA:undetectable","3hkuA-5akrA:23.90"],["4EF3_A_CUA1001_0","BLUE COPPER OXIDASE CUEO","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  95;CYH A 136;HIS A 145;MET A 150"," CU A 501 (-3.1A); CU A 501 (-2.2A); CU A 501 (-3.1A); CU A 501 (-2.4A)","0.60A","4ef3A-5akrA:20.4","4ef3A-5akrA:22.49"],["4HVC_B_HFGB1602_1","BIFUNCTIONAL GLUTAMATE\/PROLINE--TRNA LIGASE","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"HIS A  60;THR A  92;GLU A  47;HIS A 145","None;ACT A 601 ( 4.9A);None; CU A 501 (-3.1A)","1.18A","4hvcB-5akrA:undetectable","4hvcB-5akrA:20.86"],["4R7I_A_STIA1001_2","MACROPHAGE COLONY-STIMULATING FACTOR 1 RECEPTOR","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"LEU A 256;VAL A 264;VAL A 244;TYR A 293","None","1.05A","4r7iA-5akrA:undetectable","4r7iA-5akrA:21.52"],["5KPR_A_PAUA404_0","PANTOTHENATE KINASE 3","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",4,"GLU A  55;GLY A 315;ARG A  54;GLY A 225","None;None;None;ACT A 506 ( 3.4A)","1.12A","5kprA-5akrA:undetectable","5kprA-5akrA:22.64"],["5TUI_B_CTCB405_0","TETRACYCLINE DESTRUCTASE TET(50)","5akr","COPPER-CONTAINING NITRITE REDUCTASE","Achromobacter cycloclastes",5,"GLY A 152;LEU A  19;PHE A 124;VAL A  81;ILE A 154","None","1.27A","5tuiB-5akrA:undetectable","5tuiB-5akrA:22.27"]]