SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5al7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		5 / 11 LEU A 151
LEU A  47
LEU A  62
THR A  74
VAL A  76
 None
 0.76A 1ictA-5al7A:
undetectable
1ictC-5al7A:
undetectable		 1ictA-5al7A:
22.69
1ictC-5al7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_2
(TRANSTHYRETIN)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		4 / 7 LEU A  47
LEU A  62
THR A  74
VAL A  76
 None
 0.55A 1ictD-5al7A:
undetectable		 1ictD-5al7A:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		5 / 12 ILE A  98
LEU A  90
PHE A  97
LEU A 151
PRO A 152
 None
 1.07A 1jolB-5al7A:
undetectable		 1jolB-5al7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		5 / 12 ILE A  98
LEU A  90
PHE A  97
LEU A 151
PRO A 152
 None
 0.99A 1rx8A-5al7A:
undetectable		 1rx8A-5al7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUR_A_TESA339_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		5 / 10 ILE A  73
TYR A 164
ASN A  22
VAL A  21
VAL A  52
 None
 1.31A 3burA-5al7A:
undetectable		 3burA-5al7A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		4 / 5 VAL A 101
LEU A  58
ILE A  23
LEU A  24
 None
 0.79A 4mghA-5al7A:
undetectable		 4mghA-5al7A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		5 / 12 ILE A  98
LEU A  90
PHE A  97
LEU A 151
PRO A 152
 None
 1.10A 5eajB-5al7A:
undetectable		 5eajB-5al7A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPU_C_IPHC101_0
(INSULIN, CHAIN A
INSULIN, CHAIN B)		 5al7 SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG
(Drosophila
melanogaster) 		4 / 6 CYH A  45
LEU A  62
HIS A 116
LEU A 117
 None
 1.17A 5hpuC-5al7A:
undetectable
5hpuD-5al7A:
undetectable		 5hpuC-5al7A:
7.37
5hpuD-5al7A:
8.17