SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5alc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8I_A_H4BA902_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.13A 1m8iA-5alcH:
0.0		 1m8iA-5alcH:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8I_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.20A 1m8iB-5alcH:
0.0		 1m8iB-5alcH:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R35_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.21A 1r35A-5alcH:
0.0		 1r35A-5alcH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R35_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.20A 1r35B-5alcH:
0.0		 1r35B-5alcH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E67_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.09A 3e67A-5alcH:
0.0		 3e67A-5alcH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E67_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 5 SER H  59
MET H  48
ILE H  69
TRP H  36
 None
 1.15A 3e67B-5alcH:
0.0		 3e67B-5alcH:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.39A 3huoA-5alcH:
undetectable		 3huoA-5alcH:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 HIS H  97
LEU H  98
GLY H  95
HIS H  35
PRO H  52
 None
 1.17A 3tm4A-5alcH:
undetectable		 3tm4A-5alcH:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 HIS H  97
LEU H  98
GLY H  95
HIS H  35
PRO H  52
 None
 1.16A 3tm4B-5alcH:
undetectable		 3tm4B-5alcH:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H 109
ALA H   9
SER H  17
THR H 116
THR H 107
 None
 1.37A 4kyaA-5alcH:
undetectable		 4kyaA-5alcH:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_E_FOLE703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H 109
ALA H   9
SER H  17
THR H 116
THR H 107
 None
 1.36A 4kyaE-5alcH:
undetectable		 4kyaE-5alcH:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_G_FOLG703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H 109
ALA H   9
SER H  17
THR H 116
THR H 107
 None
 1.36A 4kyaG-5alcH:
undetectable		 4kyaG-5alcH:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		9 / 11 SER H  33
HIS H  35
TRP H  47
ILE H  52
THR H  56
SER H  58
TYR H  99
ASP H 100
LEU H 100
 None
 0.39A 5albH-5alcH:
30.3		 5albH-5alcH:
97.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_0
(MRNA CAPPING ENZYME
P5)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 GLY H   8
PRO H 202
GLU H  10
THR H 107
VAL H 109
 None
 1.13A 5x6yA-5alcH:
undetectable		 5x6yA-5alcH:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 5alc ANTI-TICAGRELOR FAB
72, HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.05A 6drzA-5alcH:
undetectable		 6drzA-5alcH:
16.79