SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5all'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.71A 1errA-5allA:
undetectable		 1errA-5allA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 6 GLY A 266
ASP A 335
TYR A 296
TRP A 465
 None
II6  A1552 ( 3.0A)
None
None
 1.34A 1kf6M-5allA:
undetectable
1kf6N-5allA:
undetectable		 1kf6M-5allA:
22.80
1kf6N-5allA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 7 GLU A 316
LEU A 250
LEU A 340
MET A 344
 None
 0.95A 1linA-5allA:
1.9		 1linA-5allA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOW_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 7 PHE A 409
GLU A 269
TYR A 276
GLU A 446
 None
None
None
SO4  A1548 (-3.4A)
 1.48A 2aowA-5allA:
2.5		 2aowA-5allA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 4 ASP A 128
LEU A 139
GLY A 135
ARG A  99
 None
 1.38A 2j2pD-5allA:
undetectable
2j2pE-5allA:
undetectable		 2j2pD-5allA:
15.90
2j2pE-5allA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.71A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 THR A 206
ALA A 209
GLU A 212
LEU A 213
LEU A 202
 None
 0.82A 2jfaA-5allA:
undetectable		 2jfaA-5allA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 7 GLY A 266
GLY A 458
PHE A 405
PHE A 409
 None
 0.92A 2qwxA-5allA:
4.4
2qwxB-5allA:
3.0		 2qwxA-5allA:
17.81
2qwxB-5allA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 THR A 206
ALA A 209
GLU A 212
LEU A 213
ILE A 186
 None
 0.81A 2qxsA-5allA:
undetectable		 2qxsA-5allA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FO7_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 5 HIS A 265
ASP A 292
TYR A 296
PRO A 462
 None
 1.23A 3fo7A-5allA:
undetectable		 3fo7A-5allA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H1X_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 5 HIS A 265
ASP A 292
TYR A 296
PRO A 462
 None
 1.19A 3h1xA-5allA:
undetectable		 3h1xA-5allA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 6 LEU A 514
GLU A 508
PRO A 512
ARG A 516
 None
 1.42A 3ltwA-5allA:
undetectable		 3ltwA-5allA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 GLY A 337
LEU A 358
SER A 357
PHE A 267
HIS A 524
 None
None
None
None
II6  A1552 (-3.6A)
 1.39A 3pfgA-5allA:
undetectable		 3pfgA-5allA:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_1
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		12 / 12 ASP A 335
TYR A 343
ILE A 363
PHE A 381
TYR A 383
PHE A 387
LEU A 408
LEU A 428
TYR A 466
LEU A 499
HIS A 524
TRP A 525
 II6  A1552 ( 3.0A)
None
None
None
II6  A1552 (-4.2A)
None
None
None
SO4  A1550 ( 4.8A)
SO4  A1550 (-4.8A)
II6  A1552 (-3.6A)
II6  A1552 ( 4.7A)
 0.44A 4j03A-5allA:
56.8		 4j03A-5allA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4J03_A_FVSA603_2
(BIFUNCTIONAL EPOXIDE
HYDROLASE 2)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 5 TRP A 336
SER A 374
GLN A 384
MET A 469
ASN A 472
 SO4  A1550 (-3.3A)
None
None
None
None
 0.39A 4j03A-5allA:
56.8		 4j03A-5allA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J14_A_X2NA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 10 ALA A 280
LEU A 281
VAL A 261
ALA A 546
ALA A 356
 None
 1.09A 4j14A-5allA:
undetectable		 4j14A-5allA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.90A 4jecB-5allA:
undetectable		 4jecB-5allA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 6 THR A 125
GLU A 152
THR A 123
LEU A 136
 None
 1.01A 4pgfA-5allA:
5.4		 4pgfA-5allA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UG5_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		3 / 3 ARG A 516
THR A 360
TRP A 342
 None
SO4  A1550 ( 4.0A)
None
 1.28A 4ug5A-5allA:
undetectable		 4ug5A-5allA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 8 ASN A 366
PRO A 367
MET A 369
TYR A 343
 None
 1.50A 4v2zB-5allA:
undetectable		 4v2zB-5allA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WW7_A_ACTA302_0
(EKC/KEOPS COMPLEX
SUBUNIT BUD32)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 5 PRO A 279
MET A 145
HIS A 146
LEU A 110
 None
 1.47A 4ww7A-5allA:
0.0		 4ww7A-5allA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 SER A 273
HIS A 334
ASP A 496
HIS A 524
GLY A 523
 None
None
None
II6  A1552 (-3.6A)
None
 1.31A 5eenA-5allA:
undetectable		 5eenA-5allA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 THR A 360
LEU A 358
LEU A 489
MET A 507
ILE A 511
 SO4  A1550 ( 4.0A)
None
None
None
None
 1.15A 5gs4A-5allA:
undetectable		 5gs4A-5allA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_D_SAMD501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 10 LEU A 263
HIS A 265
ILE A 332
GLY A 333
GLY A 337
 None
 0.91A 5o96C-5allA:
2.1
5o96D-5allA:
2.3		 5o96C-5allA:
17.92
5o96D-5allA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 6 ALA A 282
GLN A 283
GLN A 138
ASP A 134
 None
 1.27A 5y9aA-5allA:
3.3		 5y9aA-5allA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9A_A_AR3A201_1
(PEPTIDYL-TRNA
HYDROLASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 6 ALA A 284
GLN A 283
GLN A 138
ASP A 134
 None
 1.36A 5y9aA-5allA:
3.3		 5y9aA-5allA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 VAL A 261
VAL A 330
GLY A 517
THR A 360
GLY A 338
 None
None
None
SO4  A1550 ( 4.0A)
None
 1.09A 6brdC-5allA:
undetectable		 6brdC-5allA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		5 / 12 LEU A 542
GLY A 285
ALA A 284
ILE A 278
ILE A 539
 None
 0.95A 6dh3B-5allA:
undetectable		 6dh3B-5allA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5all SOLUBLE EPOXIDE
HYDROLASE
(Homo
sapiens) 		4 / 8 ASP A 129
ARG A 130
GLU A 132
ASP A  93
 None
 1.14A 6mn4B-5allA:
undetectable		 6mn4B-5allA:
20.48