SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5amp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		11 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLN A 175
GLU A 212
ASP A 214
GLU A 217
THR A 246
ARG A 251
ASP A 373
 None
 0.32A 1dy4A-5ampA:
64.2		 1dy4A-5ampA:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_1
(EXOGLUCANASE 1)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		10 / 12 ALA A 143
TYR A 145
TYR A 171
ASP A 173
SER A 174
GLN A 175
GLU A 212
ASP A 214
THR A 246
ARG A 251
 None
 0.60A 1dy4A-5ampA:
64.2		 1dy4A-5ampA:
63.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DY4_A_SNPA437_2
(EXOGLUCANASE 1)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 5 HIS A 228
TRP A 371
TYR A 375
ALA A 376
TRP A 380
 None
 0.35A 1dy4A-5ampA:
64.2		 1dy4A-5ampA:
63.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		6 / 12 PHE A 341
PHE A 263
TYR A 333
GLY A 326
SER A 319
GLY A 269
 None
None
None
PEG  A 901 ( 4.7A)
None
None
 1.43A 1igxA-5ampA:
undetectable		 1igxA-5ampA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 6 TYR A 167
ASP A  74
THR A  10
GLU A   9
 None
 1.45A 2dttB-5ampA:
undetectable
2dttC-5ampA:
undetectable		 2dttB-5ampA:
12.87
2dttC-5ampA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_B_TACB1888_1
(ELONGATION FACTOR
EF-TU)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 5 SER A 229
ASP A 257
PRO A 227
SER A 355
 None
 1.44A 2hdnA-5ampA:
undetectable
2hdnB-5ampA:
undetectable
2hdnD-5ampA:
undetectable		 2hdnA-5ampA:
6.41
2hdnB-5ampA:
19.69
2hdnD-5ampA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		3 / 3 GLY A 168
ARG A  39
TYR A 109
 None
 0.79A 2opxA-5ampA:
undetectable		 2opxA-5ampA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_1
(ADENOSINE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 12 SER A 319
GLY A 269
PHE A 263
GLN A 337
GLY A 396
 None
 0.92A 2pkkA-5ampA:
undetectable		 2pkkA-5ampA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 12 VAL A 155
ALA A 165
THR A 119
ALA A 151
ASP A 152
 None
 1.33A 2qm9A-5ampA:
undetectable		 2qm9A-5ampA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 6 ILE A 426
TYR A 423
MET A 146
ILE A 215
 None
 1.19A 3eteA-5ampA:
undetectable
3eteE-5ampA:
undetectable		 3eteA-5ampA:
20.68
3eteE-5ampA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_C_H3PC554_1
(GLUTAMATE
DEHYDROGENASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 5 ILE A 426
TYR A 423
MET A 146
ILE A 215
 None
 1.20A 3eteB-5ampA:
undetectable
3eteC-5ampA:
undetectable		 3eteB-5ampA:
20.68
3eteC-5ampA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 8 ASP A 214
GLY A 260
GLU A 217
ARG A 251
 None
 0.98A 3s3nA-5ampA:
undetectable		 3s3nA-5ampA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFU_A_RBVA601_1
(RNA POLYMERASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 9 ASP A 382
SER A 383
THR A 404
GLY A 407
ASP A 372
 None
 1.39A 3sfuA-5ampA:
undetectable		 3sfuA-5ampA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 4 LEU A 136
GLY A 142
MET A 378
PHE A  95
 None
 1.44A 3vaqB-5ampA:
undetectable		 3vaqB-5ampA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 11 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.31A 4c5lA-5ampA:
undetectable		 4c5lA-5ampA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 9 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.28A 4c5lB-5ampA:
undetectable		 4c5lB-5ampA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_C_UEGC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.30A 4c5lC-5ampA:
undetectable		 4c5lC-5ampA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.28A 4c5lD-5ampA:
undetectable		 4c5lD-5ampA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_B_PXLB300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 10 GLY A 170
ALA A 165
GLY A 153
MET A 149
VAL A 365
 None
 1.30A 4c5nB-5ampA:
undetectable		 4c5nB-5ampA:
20.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4IPM_A_ACTA503_0
(GH7 FAMILY PROTEIN)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		9 / 9 ASN A 141
ALA A 143
TYR A 145
TYR A 171
ASP A 173
GLU A 212
ASP A 214
GLU A 217
TRP A 371
 None
 0.45A 4ipmA-5ampA:
62.5		 4ipmA-5ampA:
54.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 5 TYR A 171
SER A 369
ASP A 214
ASP A 262
 None
 1.07A 4qtuB-5ampA:
undetectable		 4qtuB-5ampA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 5 GLY A   4
THR A   5
HIS A  42
GLY A  46
 None
 0.81A 4v20A-5ampA:
68.0		 4v20A-5ampA:
71.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 12 ARG A 178
GLY A 202
ASN A 188
GLY A  53
GLY A 191
 None
None
None
None
NAG  A 702 ( 4.2A)
 1.25A 5hikA-5ampA:
undetectable		 5hikA-5ampA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		4 / 7 GLN A 190
GLY A 205
ILE A 183
TRP A 192
 NAG  A 702 (-3.7A)
NAG  A 701 ( 3.7A)
None
None
 1.16A 5vlmC-5ampA:
undetectable		 5vlmC-5ampA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 5amp CELLOBIOHYDROLASE I
(Galactomyces
candidus) 		5 / 9 ILE A  84
LEU A 370
GLY A 105
ASN A 103
ALA A 143
 None
 1.38A 5x66C-5ampA:
undetectable		 5x66C-5ampA:
17.98