SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5amq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 MET A1557
LEU A1560
SER A1561
 None
 0.68A 1ee2A-5amqA:
undetectable		 1ee2A-5amqA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_1
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 ILE A 442
MET A 284
VAL A 288
VAL A 684
ILE A 690
 None
 1.03A 1epbA-5amqA:
undetectable		 1epbA-5amqA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_1
(ESTROGEN RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		6 / 12 THR A1281
ALA A1282
LEU A1256
LEU A1257
LEU A1341
LEU A1729
 None
 1.36A 1errB-5amqA:
undetectable		 1errB-5amqA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IIU_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 11 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.09A 1iiuA-5amqA:
undetectable		 1iiuA-5amqA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 11 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.48A 1klmA-5amqA:
4.6		 1klmA-5amqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT4_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.08A 1kt4A-5amqA:
undetectable		 1kt4A-5amqA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT5_A_RTLA176_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 LEU A1109
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.05A 1kt5A-5amqA:
undetectable		 1kt5A-5amqA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LW0_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.47A 1lw0A-5amqA:
6.4		 1lw0A-5amqA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 LEU A1083
MET A 937
PHE A1094
ILE A 930
ILE A 977
 None
 1.40A 1osvB-5amqA:
2.9		 1osvB-5amqA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAB_E_RTLE1_0
(PROTEIN (RETINOL
BINDING PROTEIN))		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 11 PHE A1111
LEU A1114
ALA A 899
MET A 900
TYR A 903
 None
 1.37A 1qabE-5amqA:
undetectable		 1qabE-5amqA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 THR A 649
SER A 644
PHE A 682
LEU A1257
 None
 1.10A 1qcaA-5amqA:
3.1		 1qcaA-5amqA:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 LEU A1397
GLU A1393
ILE A1570
TYR A1574
 None
 0.97A 1qvtA-5amqA:
undetectable		 1qvtA-5amqA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_A_DESA129_1
(TRANSTHYRETIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 4 LYS A1236
LEU A1001
LEU A1241
SER A1250
 None
 1.48A 1tt6A-5amqA:
undetectable		 1tt6A-5amqA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA130_1
(FATTY ACID-BINDING
PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 TYR A1120
ARG A 292
GLN A 291
 G  C   7 ( 3.5A)
U  C   6 ( 3.1A)
U  C   6 ( 4.1A)
 0.97A 1tw4A-5amqA:
undetectable		 1tw4A-5amqA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 9 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.47A 1vrtA-5amqA:
5.4		 1vrtA-5amqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XR2_B_C2FB1201_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 THR A 811
SER A 233
ARG A 235
GLU A 224
 None
 1.25A 1xr2B-5amqA:
undetectable		 1xr2B-5amqA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 THR A1428
GLY A1267
GLN A1510
ILE A1519
PHE A1549
 None
 1.35A 2azxB-5amqA:
undetectable		 2azxB-5amqA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 LYS A 673
ASP A1187
ASN A1225
 None
 1.01A 2bm9A-5amqA:
undetectable		 2bm9A-5amqA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 LYS A1474
ASP A 913
CYH A 843
 None
 1.31A 2br4F-5amqA:
undetectable		 2br4F-5amqA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ILE A1091
ARG A 818
LEU A1083
GLU A1087
 None
 0.89A 2cdqA-5amqA:
undetectable		 2cdqA-5amqA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		6 / 9 LEU A 138
GLY A  38
ASP A  79
ASP A  92
ILE A  47
ILE A 129
 None
 1.38A 2idwB-5amqA:
undetectable		 2idwB-5amqA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 ARG A1493
VAL A1472
THR A1689
 None
 0.73A 2nmzA-5amqA:
undetectable		 2nmzA-5amqA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 ILE A  91
ILE A 129
LEU A  45
ASN A  46
VAL A 154
 None
 1.09A 2nnhB-5amqA:
undetectable		 2nnhB-5amqA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 PHE A1094
PHE A 943
PHE A 945
 None
 0.70A 2od9A-5amqA:
undetectable		 2od9A-5amqA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		6 / 12 MET A1302
LEU A1305
THR A1306
LEU A1512
LEU A 519
MET A 515
 None
None
None
C  B  10 ( 4.2A)
None
None
 1.42A 2ouzA-5amqA:
undetectable		 2ouzA-5amqA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q8H_A_TF4A438_1
([PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 6 LEU A  88
TYR A  83
ILE A  59
ILE A 122
 None
 0.95A 2q8hA-5amqA:
undetectable		 2q8hA-5amqA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 PHE A1094
PHE A 943
PHE A 945
 None
 0.70A 2qqgA-5amqA:
undetectable		 2qqgA-5amqA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 SER A1342
VAL A1738
TYR A1596
ILE A1730
 None
 1.15A 2x45B-5amqA:
undetectable		 2x45B-5amqA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 SER A1342
VAL A1738
TYR A1596
ILE A1730
 None
 1.13A 2x45C-5amqA:
undetectable		 2x45C-5amqA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 TRP A1293
ARG A 484
ILE A1344
HIS A1300
 None
 0.98A 2xadA-5amqA:
undetectable		 2xadA-5amqA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 TRP A1293
ARG A 484
ILE A1344
HIS A1300
 None
 1.02A 2xadB-5amqA:
undetectable		 2xadB-5amqA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 TRP A1293
ARG A 484
ILE A1344
HIS A1300
 None
 0.98A 2xadC-5amqA:
undetectable		 2xadC-5amqA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 TRP A1293
ARG A 484
ILE A1344
HIS A1300
 None
 0.99A 2xadD-5amqA:
undetectable		 2xadD-5amqA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 TYR A1163
CYH A1217
GLN A1190
SER A1182
 None
 1.17A 2xz5A-5amqA:
undetectable
2xz5B-5amqA:
undetectable		 2xz5A-5amqA:
6.82
2xz5B-5amqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 GLN A1190
SER A1182
TYR A1163
CYH A1217
 None
 1.21A 2xz5A-5amqA:
undetectable
2xz5C-5amqA:
undetectable		 2xz5A-5amqA:
6.82
2xz5C-5amqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 GLN A1190
SER A1182
TYR A1163
CYH A1217
 None
 1.20A 2xz5D-5amqA:
undetectable
2xz5E-5amqA:
undetectable		 2xz5D-5amqA:
6.82
2xz5E-5amqA:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 SER A 520
ASN A 517
ILE A1298
ASP A1271
PHE A 476
 A  B  11 ( 3.6A)
C  B  12 ( 3.2A)
None
None
None
 1.11A 3a25A-5amqA:
undetectable		 3a25A-5amqA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 1.03A 3ag2C-5amqA:
undetectable		 3ag2C-5amqA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 SER A1342
VAL A1738
TYR A1596
ILE A1730
 None
 1.15A 3bu1A-5amqA:
undetectable		 3bu1A-5amqA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 ASN A 469
GLY A 310
ILE A 308
SER A 589
HIS A 565
 None
 1.39A 3bwmA-5amqA:
undetectable		 3bwmA-5amqA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_0
(REPRESSOR PROTEIN
MPHR(A))		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 THR A 613
LEU A 612
LEU A1349
ILE A 477
ILE A1331
 None
 0.98A 3frqB-5amqA:
undetectable		 3frqB-5amqA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 TYR A1098
PHE A 943
THR A 836
GLY A 963
 None
 0.91A 3gssB-5amqA:
undetectable		 3gssB-5amqA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_4
(HIV-1 PROTEASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 ARG A1493
VAL A1472
THR A1689
 None
 0.75A 3k4vD-5amqA:
undetectable		 3k4vD-5amqA:
3.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 GLU A1089
LEU A1079
TRP A1075
ASN A 239
 None
 1.42A 3k8mA-5amqA:
2.9		 3k8mA-5amqA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEE_A_T27A561_1
(P66 REVERSE
TRANSCRIPTASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.50A 3meeA-5amqA:
6.1		 3meeA-5amqA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_B_URFB521_1
(RNA DEPENDENT RNA
POLYMERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 4 ARG A 958
ASP A1060
ASP A1187
ASP A1188
 None
 1.00A 3naiB-5amqA:
7.7		 3naiB-5amqA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 GLN A   7
LEU A 167
LEU A 164
ILE A  13
 None
 0.88A 3nbqC-5amqA:
undetectable		 3nbqC-5amqA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 GLU A1509
PHE A1513
GLN A 377
 None
C  B  10 ( 4.6A)
A  B   9 ( 4.0A)
 0.87A 3r55A-5amqA:
undetectable		 3r55A-5amqA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ASP A1526
GLY A1523
TYR A1528
GLU A1687
 None
 1.01A 3s3mA-5amqA:
undetectable		 3s3mA-5amqA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ASP A1526
GLY A1523
TYR A1528
GLU A1687
 None
 1.01A 3s3nA-5amqA:
undetectable		 3s3nA-5amqA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 5 THR A 113
ILE A 116
PHE A  55
LEU A  88
 None
 1.26A 3tf1A-5amqA:
3.7		 3tf1A-5amqA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 TYR A1098
GLU A 966
TYR A 965
 None
 0.99A 3ug8A-5amqA:
undetectable		 3ug8A-5amqA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 ILE A 294
VAL A 285
ASP A 446
SER A 647
ILE A 442
 None
 1.38A 3um5B-5amqA:
undetectable		 3um5B-5amqA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.92A 3x2qC-5amqA:
undetectable
3x2qJ-5amqA:
undetectable		 3x2qC-5amqA:
7.40
3x2qJ-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.93A 3x2qP-5amqA:
undetectable
3x2qW-5amqA:
undetectable		 3x2qP-5amqA:
7.40
3x2qW-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_C_HCYC1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 SER A 330
PHE A 545
ILE A 543
SER A 560
HIS A 578
 None
 1.37A 4c49C-5amqA:
undetectable		 4c49C-5amqA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 SER A  98
ASN A 237
GLU A 245
ASN A  99
 None
 1.09A 4d33B-5amqA:
undetectable		 4d33B-5amqA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 SER A  98
ASN A 237
GLU A 245
ASN A  99
 None
 1.05A 4d39A-5amqA:
2.4		 4d39A-5amqA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 SER A  98
ASN A 237
GLU A 245
ASN A  99
 None
 1.09A 4d39B-5amqA:
undetectable		 4d39B-5amqA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		6 / 10 LEU A 138
GLY A  38
ASP A  79
ASP A  92
ILE A  47
ILE A 129
 None
 1.41A 4dqfB-5amqA:
undetectable		 4dqfB-5amqA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 6 GLU A1056
ILE A1057
ASN A1058
HIS A1156
 None
 1.11A 4ejwB-5amqA:
undetectable		 4ejwB-5amqA:
5.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 TYR A1553
ASN A1315
VAL A1518
LEU A1427
 None
 1.07A 4f8hA-5amqA:
undetectable
4f8hB-5amqA:
undetectable		 4f8hA-5amqA:
9.20
4f8hB-5amqA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0B_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 9 LEU A  45
VAL A 127
TYR A  93
LEU A  82
TYR A 149
 None
 1.46A 4q0bC-5amqA:
7.0		 4q0bC-5amqA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 PHE A 618
ILE A 730
THR A 637
LEU A1257
LEU A 747
 None
 1.43A 4qynB-5amqA:
undetectable		 4qynB-5amqA:
4.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 ILE A 518
PHE A 511
LEU A 596
ILE A 594
 None
None
None
G  C   2 ( 4.3A)
 0.79A 4rmjA-5amqA:
undetectable		 4rmjA-5amqA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 ASN A 229
GLU A 822
LEU A 179
THR A 190
ALA A 191
 None
 1.28A 4yhaH-5amqA:
undetectable		 4yhaH-5amqA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYJ_A_OQRA302_0
(SULFOTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 PHE A1208
ILE A1205
VAL A1180
GLY A1176
THR A1172
 None
 1.13A 5byjA-5amqA:
undetectable		 5byjA-5amqA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 SER A1005
PRO A1248
LEU A1001
LEU A 998
 None
 0.87A 5dzkd-5amqA:
undetectable
5dzkr-5amqA:
undetectable		 5dzkd-5amqA:
6.74
5dzkr-5amqA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 SER A1005
PRO A1248
LEU A1001
LEU A 998
 None
 1.01A 5dzkF-5amqA:
undetectable
5dzkT-5amqA:
undetectable		 5dzkF-5amqA:
6.74
5dzkT-5amqA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 5 GLY A1475
ASP A1480
ARG A1628
MET A1688
 None
 1.41A 5gwkA-5amqA:
undetectable		 5gwkA-5amqA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 12 ASN A 469
GLY A 310
ILE A 308
SER A 589
HIS A 565
 None
 1.38A 5lsaA-5amqA:
undetectable		 5lsaA-5amqA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A1001
ILE A1193
GLU A1056
ASN A1189
 None
 0.99A 5n5dA-5amqA:
undetectable		 5n5dA-5amqA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 THR A1717
PHE A1721
LEU A1711
SER A1342
 None
 1.28A 5uxcA-5amqA:
undetectable		 5uxcA-5amqA:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_B_SAMB901_0
(MRNA CAPPING ENZYME
P5)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 10 VAL A1347
GLY A1348
SER A1351
LEU A1354
ASN A1353
 None
 0.99A 5x6yB-5amqA:
undetectable		 5x6yB-5amqA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.94A 5z85C-5amqA:
undetectable
5z85J-5amqA:
undetectable		 5z85C-5amqA:
7.40
5z85J-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.92A 5zcoC-5amqA:
undetectable
5zcoJ-5amqA:
undetectable		 5zcoC-5amqA:
7.40
5zcoJ-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 7 LEU A 747
GLN A 744
PHE A 751
LEU A1257
 None
 0.95A 5zcqP-5amqA:
undetectable
5zcqW-5amqA:
undetectable		 5zcqP-5amqA:
7.40
5zcqW-5amqA:
2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 9 ILE A 543
SER A 589
PHE A 344
SER A 328
GLY A 348
 None
 1.38A 6awpA-5amqA:
0.6		 6awpA-5amqA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 PHE A1208
ASP A1207
LYS A1211
 None
 0.77A 6awtD-5amqA:
3.9		 6awtD-5amqA:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ILE A 442
THR A 678
THR A 642
SER A 955
 None
None
A  C   4 ( 3.5A)
None
 1.05A 6c06C-5amqA:
undetectable		 6c06C-5amqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		5 / 9 VAL A1386
LEU A1357
VAL A1572
SER A1575
ASP A1569
 None
 1.30A 6c2mB-5amqA:
undetectable		 6c2mB-5amqA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		3 / 3 TYR A1447
ASP A1449
GLN A1448
 None
 0.96A 6g1pA-5amqA:
undetectable		 6g1pA-5amqA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 5amq RNA POLYMERASE L
(California
encephalitis
orthobunyavirus) 		4 / 8 ASP A 487
HIS A1591
ARG A 484
ASP A1338
 None
 1.05A 6mn4C-5amqA:
undetectable		 6mn4C-5amqA:
7.35