SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ams'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKO_A_EFZA999_1
(HIV-1 RT, A-CHAIN)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 105
VAL A 112
GLY A  83
TRP A 145
LEU A  91
 None
 1.21A 1fkoA-5amsA:
undetectable		 1fkoA-5amsA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 419
ALA A 418
GLY A  84
VAL A  80
ILE A  71
 None
 1.08A 1sduB-5amsA:
undetectable		 1sduB-5amsA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C8A_D_NCAD1247_0
(MONO-ADP-RIBOSYLTRAN
SFERASE C3)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 107
SER A 111
SER A 130
GLU A 110
 None
 1.10A 2c8aD-5amsA:
undetectable		 2c8aD-5amsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 148
HIS A 136
GLY A 189
ILE A 184
 None
 0.91A 2zm9A-5amsA:
undetectable		 2zm9A-5amsA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 262
THR A 212
PHE A 242
ASN A 270
GLY A 269
 None
 1.33A 3aodC-5amsA:
undetectable		 3aodC-5amsA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 6 SER A 424
GLY A  85
GLU A 156
GLU A 110
 None
 1.12A 3k9fA-5amsA:
undetectable
3k9fB-5amsA:
undetectable
3k9fD-5amsA:
undetectable		 3k9fA-5amsA:
21.68
3k9fB-5amsA:
21.68
3k9fD-5amsA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 244
ALA A 293
ALA A 275
LEU A 282
ILE A 249
 None
 0.98A 4kjjA-5amsA:
undetectable		 4kjjA-5amsA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_1
(MDR769 HIV-1
PROTEASE)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 364
ASP A 361
ILE A 335
THR A 417
VAL A 415
 None
 1.13A 4l1aA-5amsA:
undetectable		 4l1aA-5amsA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		3 / 3 LYS A 412
ARG A 413
HIS A 402
 None
 1.18A 4zbrA-5amsA:
undetectable		 4zbrA-5amsA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AUU_A_ACTA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		3 / 3 GLN A 193
TRP A 180
VAL A 179
 None
 1.08A 6auuA-5amsA:
undetectable		 6auuA-5amsA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 5 HIS A 163
GLU A 120
LEU A 191
VAL A 135
 None
 1.13A 6bc9A-5amsA:
undetectable		 6bc9A-5amsA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E5Z_A_CCSA106_0
(PROTEIN/NUCLEIC ACID
DEGLYCASE DJ-1)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		5 / 10 GLY A 292
GLY A 291
ASN A 290
ILE A 244
ALA A 293
 None
 1.12A 6e5zA-5amsA:
undetectable		 6e5zA-5amsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 5ams RIBOSOME ASSEMBLY
PROTEIN SQT1
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 144
THR A  93
HIS A  95
GLY A 141
 None
 1.09A 6gbnC-5amsA:
undetectable		 6gbnC-5amsA:
22.14