SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5an8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_E_ACTE3005_0
(BETA-CARBONIC
ANHYDRASE)		 5an8 TRPV2
(Oryctolagus
cuniculus) 		4 / 7 GLY A 443
GLY A 442
GLN A 477
TYR A 401
 None
 1.00A 1ekjE-5an8A:
undetectable
1ekjF-5an8A:
undetectable		 1ekjE-5an8A:
16.12
1ekjF-5an8A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 5an8 TRPV2
(Oryctolagus
cuniculus) 		4 / 6 ALA A 409
TYR A 401
ILE A 404
LEU A 503
 None
 0.99A 1xvaA-5an8A:
undetectable
1xvaB-5an8A:
undetectable		 1xvaA-5an8A:
18.42
1xvaB-5an8A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 5an8 TRPV2
(Oryctolagus
cuniculus) 		4 / 8 THR A 514
GLN A 518
GLN A 661
SER A 524
 None
 1.14A 2xz5C-5an8A:
undetectable
2xz5D-5an8A:
undetectable		 2xz5C-5an8A:
15.96
2xz5D-5an8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 5an8 TRPV2
(Oryctolagus
cuniculus) 		4 / 5 HIS A 436
PHE A 405
LEU A 432
PRO A 413
 None
 1.31A 4o8zA-5an8A:
undetectable		 4o8zA-5an8A:
20.33